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2019
4 Citations (Scopus)

PDK4 augments ER–mitochondria contact to dampen skeletal muscle insulin signaling during obesity

Thoudam, T., Ha, C. M., Leem, J., Chanda, D., Park, J. S., Kim, H. J., Jeon, J. H., Choi, Y. K., Liangpunsakul, S., Huh, Y. H., Kwon, T. H., Park, K. G., Harris, R., Park, K. S., Rhee, H. W. & Lee, I. K., Mar 1 2019, In : Diabetes. 68, 3, p. 571-586 16 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Skeletal Muscle
Obesity
Insulin
2 Citations (Scopus)

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Pin, F., Novinger, L. J., Huot, J. R., Harris, R., Couch, M. E., O'Connell, T. M. & Bonetto, A., Jun 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 7778-7790 13 p.

Research output: Contribution to journalArticle

Cachexia
Muscular Atrophy
Muscle
Skeletal Muscle Fibers
Neoplasms
3 Citations (Scopus)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Min, B. K., Park, S., Kang, H. J., Kim, D. W., Ham, H. J., Ha, C. M., Choi, B. J., Lee, J. Y., Oh, C. J., Yoo, E. K., Kim, H. E., Kim, B. G., Jeon, J. H., Hyeon, D. Y., Hwang, D., Kim, Y. H., Lee, C. H., Lee, T., Kim, J. W., Choi, Y. K. & 5 others, Park, K. G., Chawla, A., Lee, J., Harris, R. & Lee, I. K., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Macrophages
Phenotype
Pyruvic Acid
Insulin Resistance
Obesity

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., Hirschey, M. D. & 1 others, Cohen, H. Y., Dec 17 2019, In : Cell Reports. 29, 12, p. 4127-4143.e8

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferator-Activated Receptors
Metabolic Networks and Pathways
Pyruvic Acid
Fasting
Fatty Acids
2018
1 Citation (Scopus)

Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate

Noguchi, S., Kondo, Y., Ito, R., Katayama, T., Kazama, S., Kadota, Y., Kitaura, Y., Harris, R. & Shimomura, Y., Oct 12 2018, In : Biochemical and Biophysical Research Communications. 504, 4, p. 916-920 5 p.

Research output: Contribution to journalArticle

thiamin-diphosphate kinase
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Thiamine Pyrophosphate
Phosphotransferases
Branched Chain Amino Acids
6 Citations (Scopus)

E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells

Xu, S., Tao, J., Yang, L., Zhang, E., Boriboun, C., Zhou, J., Sun, T., Cheng, M., Huang, K., Shi, J., Dong, N., Liu, Q., Zhao, T. C., Qiu, H., Harris, R. A., Chandel, N. S., Losordo, D. W. & Qin, G., Mar 2018, In : Circulation research. 122, 5, p. 701-711 11 p.

Research output: Contribution to journalArticle

E2F1 Transcription Factor
Bone Marrow Cells
Stem Cells
Cell- and Tissue-Based Therapy
Endothelial Cells
5 Citations (Scopus)

PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

Park, B. Y., Jeon, J. H., Go, Y., Ham, H. J., Kim, J. E., Yoo, E. K., Kwon, W. H., Jeoung, N. H., Jeon, Y. H., Koo, S. H., Kim, B. G., He, L., Park, K. G., Harris, R. & Lee, I. K., Oct 1 2018, In : Diabetes. 67, 10, p. 2054-2068 15 p.

Research output: Contribution to journalArticle

Glucagon
AMP-Activated Protein Kinases
Fatty Acids
Type 4 Cyclic Nucleotide Phosphodiesterase
Adenosine Triphosphate

The SMILE transcriptional corepressor inhibits cAMP response element– binding protein (CREB)–mediated transactivation of gluconeogenic genes

Lee, J. M., Han, H. S., Jung, Y. S., Harris, R., Koo, S. H. & Choi, H. S., Jan 1 2018, In : Journal of Biological Chemistry. 293, 34, p. 13125-13133 9 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Co-Repressor Proteins
Transcription
Transcriptional Activation
Genes
2017
17 Citations (Scopus)

Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression

Kim, Y. D., Hwang, S. L., Lee, E. J., Kim, H. M., Chung, M. J., Elfadl, A. K., Lee, S. E., Nedumaran, B., Harris, R. & Jeong, K. S., Mar 1 2017, In : Journal of Pineal Research. 62, 2, e12386.

Research output: Contribution to journalArticle

Melatonin
Bile Acids and Salts
Alcohols
Yin-Yang
B-Lymphocytes
2016

Erratum: Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation (Scientific Reports 5:16577; DOI:10.1038/srep16577)

Lee, S. J., Jeong, J. Y., Oh, C. J., Park, S., Kim, J. Y., Kim, H. J., Kim, N. D., Choi, Y. K., Do, J. Y., Go, Y., Ha, C. M., Choi, J. Y., Huh, S., Jeoung, N. H., Lee, K. U., Choi, H. S., Wang, Y., Park, K. G., Harris, R. A. & Lee, I. K., Jan 27 2016, In : Scientific Reports. 6, 18552.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis

Go, Y., Jeong, J. Y., Jeoung, N. H., Jeon, J. H., Park, B. Y., Kang, H. J., Ha, C. M., Choi, Y. K., Lee, S. J., Ham, H. J., Kim, B. G., Park, K. G., Park, S. Y., Lee, C. H., Choi, C. S., Park, T. S., Paul Lee, W. N., Harris, R. & Lee, I. K., Oct 1 2016, In : Diabetes. 65, 10, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

Citric Acid Cycle
Pyruvate Dehydrogenase Complex
Liver
Insulin Resistance
Tricarboxylic Acids
10 Citations (Scopus)

Insulin-Inducible SMILE inhibits hepatic gluconeogenesis

Lee, J. M., Seo, W. Y., Han, H. S., Oh, K. J., Lee, Y. S., Kim, D. K., Choi, S., Choi, B. H., Harris, R. A., Lee, C. H., Koo, S. H. & Choi, H. S., Jan 2016, In : Diabetes. 65, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Insulin
Liver
Co-Repressor Proteins
Proto-Oncogene Proteins c-akt
20 Citations (Scopus)

Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis

Jang, J. E., Ko, M. S., Yun, J. Y., Kim, M. O., Kim, J. H., Park, H. S., Kim, A. R., Kim, H. J., Kim, B. J., Ahn, Y. E., Oh, J. S., Lee, W. J., Harris, R., Koh, E. H. & Lee, K. U., Sep 1 2016, In : Diabetes. 65, 9, p. 2516-2528 13 p.

Research output: Contribution to journalArticle

Adipocytes
Adipose Tissue
Nitric Oxide
Fibrosis
Macrophages
8 Citations (Scopus)

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A. N., Mang, H., Plotkin, Z., Dube, S., Hutchins, G. D., Territo, P. R., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R. A., Daghe, P. C. & Sutton, T. A., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

Positron-Emission Tomography
Kidney
Glucose
Glycolysis
Pharmacology
7 Citations (Scopus)

O-GlcNAcylation of orphan nuclear receptor estrogen-related receptorγ promotes hepatic gluconeogenesis

Misra, J., Kim, D. K., Jung, Y. S., Kim, H. B., Kim, Y. H., Yoo, E. K., Kim, B. G., Kim, S., Lee, I. K., Harris, R., Kim, J. S., Lee, C. H., Cho, J. W. & Choi, H. S., Oct 1 2016, In : Diabetes. 65, 10, p. 2835-2848 14 p.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
Gluconeogenesis
Estrogen Receptors
Liver
Hexosamines
15 Citations (Scopus)

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. & Broustovetski, N., 2016, In : Human Molecular Genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Mitochondria
Neurons
Brain
24 Citations (Scopus)

Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury

Oh, C. J., Ha, C. M., Choi, Y. K., Park, S., Choe, M. S., Jeoung, N. H., Huh, Y. H., Kim, H. J., Kweon, H. S., Lee, J. M., Lee, S. J., Jeon, J. H., Harris, R., Park, K. G. & Lee, I. K., Feb 2 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cisplatin
Knockout Mice
Kidney
Dichloroacetic Acid
18 Citations (Scopus)

Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy

Rahman, M. H., Jha, M. K., Kim, J. H., Nam, Y., Lee, M. G., Go, Y., Harris, R., Park, D. H., Kook, H., Lee, I. K. & Suk, K., Mar 11 2016, In : Journal of Biological Chemistry. 291, 11, p. 6011-6025 15 p.

Research output: Contribution to journalArticle

Diabetic Neuropathies
Spinal Ganglia
Medical problems
Lactic Acid
Ion Channels
23 Citations (Scopus)

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiong, X., Wang, G., Tao, R., Wu, P., Kono, T., Li, K., Ding, W. X., Tong, X., Tersey, S. A., Harris, R., Mirmira, R., Evans-Molina, C. & Dong, X., Jan 1 2016, In : Diabetologia. 59, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

Insulin-Secreting Cells
Insulin
Glucose
Knockout Mice
Oxygen Consumption
7 Citations (Scopus)

The orphan nuclear receptor erraγ regulates hepatic cb1 receptor-mediated fibroblast growth factor 21 gene expression

Jung, Y. S., Lee, J. M., Kim, D. K., Lee, Y. S., Kim, K. S., Kim, Y. H., Kim, J., Lee, M. S., Lee, I. K., Kim, S. H., Cho, S. J., Jeong, W. I., Lee, C. H., Harris, R. & Choi, H. S., Jul 1 2016, In : PLoS One. 11, 7, e0159425.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
fibroblast growth factors
Gene expression
Estrogen Receptors
Estrogens
2015
13 Citations (Scopus)

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

Chen, Y. W., Harris, R. A., Hatahet, Z. & Chou, K. M., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. E4556-E4564

Research output: Contribution to journalArticle

DNA Damage
Adipose Tissue
Adipocytes
Genes
Obesity
26 Citations (Scopus)

Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function

Kim, J. H., Bae, K. H., Choi, Y. K., Go, Y., Choe, M., Jeon, Y. H., Lee, H. W., Koo, S. H., Perfield, J. W., Harris, R. A., Lee, I. K. & Park, K. G., Feb 1 2015, In : Diabetes, Obesity and Metabolism. 17, 2, p. 161-169 9 p.

Research output: Contribution to journalArticle

Brown Adipose Tissue
Streptozocin
Blood Glucose
Insulin
Glucose
9 Citations (Scopus)

Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK

Kim, Y. D., Lee, K. M., Hwang, S. L., Chang, H. W., Kim, K. J., Harris, R., Choi, H. S., Choi, W. S., Lee, S. E. & Park, C. S., Dec 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 12, p. 2662-2670 9 p.

Research output: Contribution to journalArticle

Fenofibrate
Alcoholic Liver Diseases
AMP-Activated Protein Kinases
Peroxisome Proliferator-Activated Receptors
Alcohols
11 Citations (Scopus)

L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors

Kim, K., Jeong, J. H., Lim, D., Hong, Y., Lim, H. J., Kim, G. J., Shin, S. R., Lee, J. J., Yun, M., Harris, R., Min, J. J. & Choy, H. E., Jun 10 2015, In : Molecular Therapy - Oncolytics. 2, 1 p., 15007.

Research output: Contribution to journalArticle

Asparaginase
Salmonella typhimurium
Neoplasms
Bacteria
Proteins
20 Citations (Scopus)

Metabolic connection of inflammatory pain: Pivotal role of a pyruvate dehydrogenase kinase-pyruvate dehydrogenase-lactic acid axis

Jha, M. K., Song, G. J., Lee, M. G., Jeoung, N. H., Go, Y., Harris, R., Park, D. H., Kook, H., Lee, I. K. & Suk, K., Oct 21 2015, In : Journal of Neuroscience. 35, 42, p. 14353-14369 17 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Lactic Acid
Oxidoreductases
Pain
Freund's Adjuvant

Metabolic Regulation

Patel, M. S. & Harris, R., Jan 1 2015, Molecular Cell Biology. Elsevier Inc., Vol. 1. p. 288-297 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolic Networks and Pathways
Homeostasis
Glycogenolysis
Gluconeogenesis
Enzymes
22 Citations (Scopus)

Oxidative metabolism in YAC128 mouse model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. A. & Brustovetsky, N., Jan 1 2015, In : Human molecular genetics. 24, 17, p. 4862-4878 17 p.

Research output: Contribution to journalArticle

Huntington Disease
Corpus Striatum
Neurons
Mitochondria
Respiration
17 Citations (Scopus)

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Lee, S. J., Jeong, J. Y., Oh, C. J., Park, S., Kim, J. Y., Kim, H. J., Doo Kim, N., Choi, Y. K., Do, J. Y., Go, Y., Ha, C. M., Choi, J. Y., Huh, S., Ho Jeoung, N., Lee, K. U., Choi, H. S., Wang, Y., Park, K. G., Harris, R. & Lee, I. K., Nov 12 2015, In : Scientific Reports. 5, 16577.

Research output: Contribution to journalArticle

Vascular Calcification
Phosphorylation
Vascular Smooth Muscle
Smooth Muscle Myocytes
Phosphates
17 Citations (Scopus)

Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells

Byun, J. K., Choi, Y. K., Kang, Y. N., Jang, B. K., Kang, K. J., Jeon, Y. H., Lee, H. W., Jeon, J. H., Koo, S. H., Jeong, W. I., Harris, R. A., Lee, I. K. & Park, K. G., Mar 1 2015, In : Hepatology. 61, 3, p. 953-964 12 p.

Research output: Contribution to journalArticle

Tretinoin
Glutamine
Hepatocellular Carcinoma
Glucose
NADP
2014
8 Citations (Scopus)

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Lakhter, A. J., Hamilton, J., Dagher, P. C., Mukkamala, S., Hato, T., Dong, X. C., Mayo, L. D., Harris, R. A., Shekhar, A., Ivan, M., Brustovetsky, N. & Naidu, S. R., Jan 1 2014, In : Oncotarget. 5, 24, p. 12694-12703 10 p.

Research output: Contribution to journalArticle

Open Access
Vitamin K 3
Oxidative Phosphorylation
Glycolysis
Melanoma
Cell Death
5 Citations (Scopus)

MondoA deficiency enhances sprint performance in mice

Imamura, M., Chang, B. H. J., Kohjima, M., Li, M., Hwang, B., Taegtmeyer, H., Harris, R. A. & Chan, L., Nov 15 2014, In : Biochemical Journal. 464, p. 35-48 14 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Alanine
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Muscle
Lactic Acid
14 Citations (Scopus)

Pyruvate dehydrogenase kinase-4 contributes to the recirculation of gluconeogenic precursors during postexercise glycogen recovery

Herbst, E. A. F., Macpherson, R. E. K., Leblanc, P. J., Roy, B. D., Jeoung, N. H., Harris, R. A. & Peters, S. J., Jan 15 2014, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 306, 2, p. R102-R107

Research output: Contribution to journalArticle

Glycogen
Carbohydrates
Pyruvate Dehydrogenase Complex
Muscles
Liver Glycogen
29 Citations (Scopus)

Regulation of pyruvate metabolism in metabolic-related diseases

Jeoung, N. H., Harris, C. R. & Harris, R. A., Mar 2014, In : Reviews in Endocrine and Metabolic Disorders. 15, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Pyruvic Acid
Pyruvate Carboxylase
Glucose
Thiazolidinediones
2013
70 Citations (Scopus)

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: A critical role of PDK4

Mori, J., Alrob, O. A., Wagg, C. S., Harris, R. A., Lopaschuk, G. D. & Oudit, G. Y., Jun 10 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 8, p. H1103-H1113

Research output: Contribution to journalArticle

Angiotensin II
Insulin Resistance
Pyruvic Acid
Oxidoreductases
Insulin

Erratum to Metabolic Activation of CaMKII by Coenzyme A [(Molecular Cell, 52, (2013), 327-341]

McCoy, F., Darbandi, R., Lee, H. C., Bharatham, K., Moldoveanu, T., Grace, C. R., Dodd, K., Lin, W., Chen, S. I., Tangallapally, R. P., Kurokawa, M., Lee, R. E., Shelat, A. A., Chen, T., Green, D. R., Harris, R. A., Lin, S. H., Fissore, R. A., Colbran, R. J. & Nutt, L. K., Nov 7 2013, In : Molecular Cell. 52, 3, 1 p.

Research output: Contribution to journalComment/debate

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Coenzyme A
Metabolic Activation
8 Citations (Scopus)

General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice

She, P., Bunpo, P., Cundiff, J. K., Wek, R. C., Harris, R. A. & Anthony, T. G., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31250-31260 11 p.

Research output: Contribution to journalArticle

Branched Chain Amino Acids
Oligodendroglia
Brain
Phosphotransferases
Amino Acids
25 Citations (Scopus)

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

Tao, R., Xiong, X., Harris, R. A., White, M. F. & Dong, X. C., Aug 5 2013, In : PLoS ONE. 8, 8, e71997.

Research output: Contribution to journalArticle

pyruvate dehydrogenase (acetyl-transferring) kinase
Insulin Receptor Substrate Proteins
Medical problems
insulin resistance
diabetes
1 Citation (Scopus)

Glycolysis Overview

Harris, R., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 443-447 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycolysis
Adenosine Triphosphate
Oxygen
Cells
Pyruvic Acid
39 Citations (Scopus)

Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells

Ahn, S. W., Gang, G. T., Kim, Y. D., Ahn, R. S., Harris, R. A., Lee, C. H. & Choi, H. S., May 31 2013, In : Journal of Biological Chemistry. 288, 22, p. 15937-15946 10 p.

Research output: Contribution to journalArticle

DAX-1 Orphan Nuclear Receptor
Leydig Cells
Insulin
Gene expression
Gene Expression
23 Citations (Scopus)

Metabolic Activation of CaMKII by Coenzyme A

McCoy, F., Darbandi, R., Lee, H. C., Bharatham, K., Moldoveanu, T., Grace, C. R., Dodd, K., Lin, W., Chen, S. I., Tangallapally, R. P., Kurokawa, M., Lee, R. E., Shelat, A. A., Chen, T., Green, D. R., Harris, R. A., Lin, S. H., Fissore, R. A., Colbran, R. J. & Nutt, L. K., Nov 7 2013, In : Molecular Cell. 52, 3, p. 325-339 15 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Coenzyme A
Oocytes
Caspase 2
Apoptosis
42 Citations (Scopus)

Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity

Kim, J. K., Kim, J. Y., Kim, H. J., Park, K. G., Harris, R. A., Cho, W. J., Lee, J. T. & Lee, I. K., Nov 15 2013, In : PLoS ONE. 8, 11, e80391.

Research output: Contribution to journalArticle

scoparone
STAT3 Transcription Factor
prostatic neoplasms
Tumors
Prostatic Neoplasms
2012
10 Citations (Scopus)
Clofibric Acid
High Fat Diet
Nutrition
Isoenzymes
Fats
11 Citations (Scopus)

Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia

Bansal, A., Harris, R. A. & DeGrado, T. R., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

Choline Kinase
Phosphorylation
Transcription
Choline
Response Elements
25 Citations (Scopus)

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Jeoung, N. H., Rahimi, Y., Wu, P., Lee, W. N. P. & Harris, R. A., May 1 2012, In : Biochemical Journal. 443, 3, p. 829-839 11 p.

Research output: Contribution to journalArticle

Hypothermia
Ketosis
Knockout Mice
Fasting
Insulin
42 Citations (Scopus)

Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ

Lee, J. H., Kim, E. J., Kim, D. K., Lee, J. M., Park, S. B., Lee, I. K., Harris, R. A., Lee, M. O. & Choi, H. S., Sep 25 2012, In : PLoS ONE. 7, 9, e46324.

Research output: Contribution to journalArticle

pyruvate dehydrogenase (acetyl-transferring) kinase
Orphan Nuclear Receptors
Gene expression
Estrogen Receptors
hypoxia
18 Citations (Scopus)

Metformin inhibits growth hormone - Mediated hepatic, PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner

Kim, Y. D., Kim, Y. H., Tadi, S., Yu, J. H., Yim, Y. H., Jeoung, N. H., Shong, M., Hennighausen, L., Harris, R. A., Lee, I. K., Lee, C. H. & Choi, H. S., Oct 1 2012, In : Diabetes. 61, 10, p. 2484-2494 11 p.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
Metformin
Growth Hormone
Gene Expression
STAT5 Transcription Factor
3 Citations (Scopus)

Mitochondria and endoplasmic reticulum in diabetes and its complications

Lee, K. U. & Harris, R. A., Apr 19 2012, In : Experimental Diabetes Research. 2012, 985075.

Research output: Contribution to journalEditorial

Endoplasmic Reticulum Stress
Diabetes Complications
Endoplasmic Reticulum
Diabetes Mellitus
Mitochondria
149 Citations (Scopus)

Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy

Novarino, G., El-Fishawy, P., Kayserili, H., Meguid, N. A., Scott, E. M., Schroth, J., Silhavy, J. L., Kara, M., Khalil, R. O., Ben-Omran, T., Ercan-Sencicek, A. G., Hashish, A. F., Sanders, S. J., Gupta, A. R., Hashem, H. S., Matern, D., Gabriel, S., Sweetman, L., Rahimi, Y., Harris, R. A. & 2 others, State, M. W. & Gleeson, J. G., Oct 19 2012, In : Science. 338, 6105, p. 394-397 4 p.

Research output: Contribution to journalArticle

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Autistic Disorder
Epilepsy
Phosphotransferases
Mutation
15 Citations (Scopus)

Phosphoenolpyruvate carboxykinaseandglucose-6-phosphatase are required for steroidogenesis in testicular leydig cells

Ahn, S. W., Gang, G. T., Tadi, S., Nedumaran, B., Kim, Y. D., Park, J. H., Kweon, G. R., Koo, S. H., Lee, K., Ahn, R. S., Yim, Y. H., Lee, C. H., Harris, R. A. & Choi, H. S., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41875-41887 13 p.

Research output: Contribution to journalArticle

Phosphoenolpyruvate
Leydig Cells
Phosphoric Monoester Hydrolases
Cyclic AMP
AMP-Activated Protein Kinases
8 Citations (Scopus)

Role of pyruvate dehydrogenase kinase 4 in regulating PDH activation during acute muscle contraction

Herbst, E. A. F., Dunford, E. C. E., Harris, R. A., Vandenboom, R., LeBlanc, P. J., Roy, B. D., Jeoung, N. H. & Peters, S. J., Feb 1 2012, In : Applied Physiology, Nutrition and Metabolism. 37, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

Muscle Contraction
Pyruvic Acid
Knockout Mice
Oxidoreductases
Pyruvate Dehydrogenase Complex