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  • Robert Harris
2020

Induction of SIRT1 by melatonin improves alcohol-mediated oxidative liver injury by disrupting the CRBN-YY1-CYP2E1 signaling pathway

Lee, S. E., Koh, H., Joo, D. J., Nedumaran, B., Jeon, H. J., Park, C. S., Harris, R. A. & Kim, Y. D., Jan 1 2020, (Accepted/In press) In : Journal of Pineal Research.

Research output: Contribution to journalArticle

2019

PDK4 augments ER–mitochondria contact to dampen skeletal muscle insulin signaling during obesity

Thoudam, T., Ha, C. M., Leem, J., Chanda, D., Park, J. S., Kim, H. J., Jeon, J. H., Choi, Y. K., Liangpunsakul, S., Huh, Y. H., Kwon, T. H., Park, K. G., Harris, R. A., Park, K. S., Rhee, H. W. & Lee, I. K., Mar 1 2019, In : Diabetes. 68, 3, p. 571-586 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Pin, F., Novinger, L. J., Huot, J. R., Harris, R. A., Couch, M. E., O'Connell, T. M. & Bonetto, A., Jun 1 2019, In : FASEB Journal. 33, 6, p. 7778-7790 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pyruvate dehydrogenase kinase is a metabolic checkpoint for polarization of macrophages to the M1 phenotype

Min, B. K., Park, S., Kang, H. J., Kim, D. W., Ham, H. J., Ha, C. M., Choi, B. J., Lee, J. Y., Oh, C. J., Yoo, E. K., Kim, H. E., Kim, B. G., Jeon, J. H., Hyeon, D. Y., Hwang, D., Kim, Y. H., Lee, C. H., Lee, T., Jungwhan, K., Choi, Y. K. & 5 others, Park, K. G., Chawla, A., Lee, J., Harris, R. A. & Lee, I. K., Jan 1 2019, In : Frontiers in immunology. 10, MAY, 944.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., Hirschey, M. D. & 1 others, Cohen, H. Y., Dec 17 2019, In : Cell Reports. 29, 12, p. 4127-4143.e8

Research output: Contribution to journalArticle

Open Access
2018

Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate

Noguchi, S., Kondo, Y., Ito, R., Katayama, T., Kazama, S., Kadota, Y., Kitaura, Y., Harris, R. A. & Shimomura, Y., Oct 12 2018, In : Biochemical and Biophysical Research Communications. 504, 4, p. 916-920 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells

Xu, S., Tao, J., Yang, L., Zhang, E., Boriboun, C., Zhou, J., Sun, T., Cheng, M., Huang, K., Shi, J., Dong, N., Liu, Q., Zhao, T. C., Qiu, H., Harris, R. A., Chandel, N. S., Losordo, D. W. & Qin, G., Mar 2018, In : Circulation research. 122, 5, p. 701-711 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

PDK4 deficiency suppresses hepatic glucagon signaling by decreasing cAMP levels

Park, B. Y., Jeon, J. H., Go, Y., Ham, H. J., Kim, J. E., Yoo, E. K., Kwon, W. H., Jeoung, N. H., Jeon, Y. H., Koo, S. H., Kim, B. G., He, L., Park, K. G., Harris, R. A. & Lee, I. K., Oct 2018, In : Diabetes. 67, 10, p. 2054-2068 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

The SMILE transcriptional corepressor inhibits cAMP response element– binding protein (CREB)–mediated transactivation of gluconeogenic genes

Lee, J. M., Han, H. S., Jung, Y. S., Harris, R. A., Koo, S. H. & Choi, H. S., Aug 24 2018, In : Journal of Biological Chemistry. 293, 34, p. 13125-13133 9 p.

Research output: Contribution to journalArticle

2017

Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression

Kim, Y. D., Hwang, S. L., Lee, E. J., Kim, H. M., Chung, M. J., Elfadl, A. K., Lee, S. E., Nedumaran, B., Harris, R. & Jeong, K. S., Mar 1 2017, In : Journal of Pineal Research. 62, 2, e12386.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation (Scientific Reports 5:16577; DOI:10.1038/srep16577)

Lee, S. J., Jeong, J. Y., Oh, C. J., Park, S., Kim, J. Y., Kim, H. J., Kim, N. D., Choi, Y. K., Do, J. Y., Go, Y., Ha, C. M., Choi, J. Y., Huh, S., Jeoung, N. H., Lee, K. U., Choi, H. S., Wang, Y., Park, K. G., Harris, R. A. & Lee, I. K., Jan 27 2016, In : Scientific reports. 6, 18552.

Research output: Contribution to journalComment/debate

Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis

Go, Y., Jeong, J. Y., Jeoung, N. H., Jeon, J. H., Park, B. Y., Kang, H. J., Ha, C. M., Choi, Y. K., Lee, S. J., Ham, H. J., Kim, B. G., Park, K. G., Park, S. Y., Lee, C. H., Choi, C. S., Park, T. S., Paul Lee, W. N., Harris, R. & Lee, I. K., Oct 1 2016, In : Diabetes. 65, 10, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Insulin-Inducible SMILE inhibits hepatic gluconeogenesis

Lee, J. M., Seo, W. Y., Han, H. S., Oh, K. J., Lee, Y. S., Kim, D. K., Choi, S., Choi, B. H., Harris, R. A., Lee, C. H., Koo, S. H. & Choi, H. S., Jan 2016, In : Diabetes. 65, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Metabolic Regulation

Patel, M. S. & Harris, R. A., Jan 1 2016, Molecular Cell Biology. Elsevier Inc., Vol. 1. p. 288-297 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis

Jang, J. E., Ko, M. S., Yun, J. Y., Kim, M. O., Kim, J. H., Park, H. S., Kim, A. R., Kim, H. J., Kim, B. J., Ahn, Y. E., Oh, J. S., Lee, W. J., Harris, R. A., Koh, E. H. & Lee, K. U., Sep 1 2016, In : Diabetes. 65, 9, p. 2516-2528 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A. N., Mang, H., Plotkin, Z., Dube, S., Hutchins, G. D., Territo, P. R., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R. A., Daghe, P. C. & Sutton, T. A., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

9 Scopus citations

O-GlcNAcylation of orphan nuclear receptor estrogen-related receptorγ promotes hepatic gluconeogenesis

Misra, J., Kim, D. K., Jung, Y. S., Kim, H. B., Kim, Y. H., Yoo, E. K., Kim, B. G., Kim, S., Lee, I. K., Harris, R. A., Kim, J. S., Lee, C. H., Cho, J. W. & Choi, H. S., Oct 1 2016, In : Diabetes. 65, 10, p. 2835-2848 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. A. & Brustovetsky, N., Jan 1 2016, In : Human molecular genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury

Oh, C. J., Ha, C. M., Choi, Y. K., Park, S., Choe, M. S., Jeoung, N. H., Huh, Y. H., Kim, H. J., Kweon, H. S., Lee, J. M., Lee, S. J., Jeon, J. H., Harris, R., Park, K. G. & Lee, I. K., Feb 2 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

29 Scopus citations

Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy

Rahman, M. H., Jha, M. K., Kim, J. H., Nam, Y., Lee, M. G., Go, Y., Harris, R. A., Park, D. H., Kook, H., Lee, I. K. & Suk, K., Mar 11 2016, In : Journal of Biological Chemistry. 291, 11, p. 6011-6025 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiong, X., Wang, G., Tao, R., Wu, P., Kono, T., Li, K., Ding, W. X., Tong, X., Tersey, S. A., Harris, R. A., Mirmira, R. G., Evans-Molina, C. & Dong, X. C., Jan 1 2016, In : Diabetologia. 59, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

The orphan nuclear receptor erraγ regulates hepatic cb1 receptor-mediated fibroblast growth factor 21 gene expression

Jung, Y. S., Lee, J. M., Kim, D. K., Lee, Y. S., Kim, K. S., Kim, Y. H., Kim, J., Lee, M. S., Lee, I. K., Kim, S. H., Cho, S. J., Jeong, W. I., Lee, C. H., Harris, R. A. & Choi, H. S., Jul 2016, In : PloS one. 11, 7, e0159425.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

Chen, Y. W., Harris, R. A., Hatahet, Z. & Chou, K. M., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. E4556-E4564

Research output: Contribution to journalArticle

15 Scopus citations

Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function

Kim, J. H., Bae, K. H., Choi, Y. K., Go, Y., Choe, M., Jeon, Y. H., Lee, H. W., Koo, S. H., Perfield, J. W., Harris, R. A., Lee, I. K. & Park, K. G., Feb 1 2015, In : Diabetes, Obesity and Metabolism. 17, 2, p. 161-169 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK

Kim, Y. D., Lee, K. M., Hwang, S. L., Chang, H. W., Kim, K. J., Harris, R. A., Choi, H. S., Choi, W. S., Lee, S. E. & Park, C. S., Dec 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 12, p. 2662-2670 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors

Kim, K., Jeong, J. H., Lim, D., Hong, Y., Lim, H. J., Kim, G. J., Shin, S. R., Lee, J. J., Yun, M., Harris, R. A., Min, J. J. & Choy, H. E., Jun 10 2015, In : Molecular Therapy - Oncolytics. 2, 1 p., 15007.

Research output: Contribution to journalArticle

14 Scopus citations

Metabolic connection of inflammatory pain: Pivotal role of a pyruvate dehydrogenase kinase-pyruvate dehydrogenase-lactic acid axis

Jha, M. K., Song, G. J., Lee, M. G., Jeoung, N. H., Go, Y., Harris, R. A., Park, D. H., Kook, H., Lee, I. K. & Suk, K., Oct 21 2015, In : Journal of Neuroscience. 35, 42, p. 14353-14369 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Oxidative metabolism in YAC128 mouse model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. A. & Brustovetsky, N., Jan 1 2015, In : Human molecular genetics. 24, 17, p. 4862-4878 17 p.

Research output: Contribution to journalArticle

22 Scopus citations

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Lee, S. J., Jeong, J. Y., Oh, C. J., Park, S., Kim, J. Y., Kim, H. J., Doo Kim, N., Choi, Y. K., Do, J. Y., Go, Y., Ha, C. M., Choi, J. Y., Huh, S., Ho Jeoung, N., Lee, K. U., Choi, H. S., Wang, Y., Park, K. G., Harris, R. A. & Lee, I. K., Nov 12 2015, In : Scientific reports. 5, 16577.

Research output: Contribution to journalArticle

19 Scopus citations

Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells

Byun, J. K., Choi, Y. K., Kang, Y. N., Jang, B. K., Kang, K. J., Jeon, Y. H., Lee, H. W., Jeon, J. H., Koo, S. H., Jeong, W. I., Harris, R. A., Lee, I. K. & Park, K. G., Mar 1 2015, In : Hepatology. 61, 3, p. 953-964 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Lakhter, A. J., Hamilton, J., Dagher, P. C., Mukkamala, S., Hato, T., Dong, X. C., Mayo, L. D., Harris, R. A., Shekhar, A., Ivan, M., Brustovetsky, N. & Naidu, S. R., Jan 1 2014, In : Oncotarget. 5, 24, p. 12694-12703 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

MondoA deficiency enhances sprint performance in mice

Imamura, M., Chang, B. H. J., Kohjima, M., Li, M., Hwang, B., Taegtmeyer, H., Harris, R. A. & Chan, L., Nov 15 2014, In : Biochemical Journal. 464, p. 35-48 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pyruvate dehydrogenase kinase-4 contributes to the recirculation of gluconeogenic precursors during postexercise glycogen recovery

Herbst, E. A. F., Macpherson, R. E. K., Leblanc, P. J., Roy, B. D., Jeoung, N. H., Harris, R. A. & Peters, S. J., Jan 15 2014, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 306, 2, p. R102-R107

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of pyruvate metabolism in metabolic-related diseases

Jeoung, N. H., Harris, C. R. & Harris, R. A., Mar 2014, In : Reviews in Endocrine and Metabolic Disorders. 15, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: A critical role of PDK4

Mori, J., Alrob, O. A., Wagg, C. S., Harris, R. A., Lopaschuk, G. D. & Oudit, G. Y., Jun 10 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 8, p. H1103-H1113

Research output: Contribution to journalArticle

75 Scopus citations

Erratum to Metabolic Activation of CaMKII by Coenzyme A [(Molecular Cell, 52, (2013), 327-341]

McCoy, F., Darbandi, R., Lee, H. C., Bharatham, K., Moldoveanu, T., Grace, C. R., Dodd, K., Lin, W., Chen, S. I., Tangallapally, R. P., Kurokawa, M., Lee, R. E., Shelat, A. A., Chen, T., Green, D. R., Harris, R. A., Lin, S. H., Fissore, R. A., Colbran, R. J. & Nutt, L. K., Nov 7 2013, In : Molecular Cell. 52, 3, 1 p.

Research output: Contribution to journalComment/debate

General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice

She, P., Bunpo, P., Cundiff, J. K., Wek, R. C., Harris, R. A. & Anthony, T. G., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31250-31260 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

Tao, R., Xiong, X., Harris, R. A., White, M. F. & Dong, X. C., Aug 5 2013, In : PLoS ONE. 8, 8, e71997.

Research output: Contribution to journalArticle

25 Scopus citations

Glycolysis Overview

Harris, R., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 443-447 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells

Ahn, S. W., Gang, G. T., Kim, Y. D., Ahn, R. S., Harris, R. A., Lee, C. H. & Choi, H. S., May 31 2013, In : Journal of Biological Chemistry. 288, 22, p. 15937-15946 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Metabolic Activation of CaMKII by Coenzyme A

McCoy, F., Darbandi, R., Lee, H. C., Bharatham, K., Moldoveanu, T., Grace, C. R., Dodd, K., Lin, W., Chen, S. I., Tangallapally, R. P., Kurokawa, M., Lee, R. E., Shelat, A. A., Chen, T., Green, D. R., Harris, R. A., Lin, S. H., Fissore, R. A., Colbran, R. J. & Nutt, L. K., Nov 7 2013, In : Molecular Cell. 52, 3, p. 325-339 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity

Kim, J. K., Kim, J. Y., Kim, H. J., Park, K. G., Harris, R. A., Cho, W. J., Lee, J. T. & Lee, I. K., Nov 15 2013, In : PLoS ONE. 8, 11, e80391.

Research output: Contribution to journalArticle

43 Scopus citations
2012
10 Scopus citations

Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia

Bansal, A., Harris, R. A. & DeGrado, T. R., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Jeoung, N. H., Rahimi, Y., Wu, P., Lee, W. N. P. & Harris, R. A., May 1 2012, In : Biochemical Journal. 443, 3, p. 829-839 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ

Lee, J. H., Kim, E. J., Kim, D. K., Lee, J. M., Park, S. B., Lee, I. K., Harris, R. A., Lee, M. O. & Choi, H. S., Sep 25 2012, In : PLoS ONE. 7, 9, e46324.

Research output: Contribution to journalArticle

42 Scopus citations

Metformin inhibits growth hormone - Mediated hepatic, PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner

Kim, Y. D., Kim, Y. H., Tadi, S., Yu, J. H., Yim, Y. H., Jeoung, N. H., Shong, M., Hennighausen, L., Harris, R. A., Lee, I. K., Lee, C. H. & Choi, H. S., Oct 1 2012, In : Diabetes. 61, 10, p. 2484-2494 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mitochondria and endoplasmic reticulum in diabetes and its complications

Lee, K. U. & Harris, R. A., Apr 19 2012, In : Experimental Diabetes Research. 2012, 985075.

Research output: Contribution to journalEditorial

3 Scopus citations

Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy

Novarino, G., El-Fishawy, P., Kayserili, H., Meguid, N. A., Scott, E. M., Schroth, J., Silhavy, J. L., Kara, M., Khalil, R. O., Ben-Omran, T., Ercan-Sencicek, A. G., Hashish, A. F., Sanders, S. J., Gupta, A. R., Hashem, H. S., Matern, D., Gabriel, S., Sweetman, L., Rahimi, Y., Harris, R. A. & 2 others, State, M. W. & Gleeson, J. G., Oct 19 2012, In : Science. 338, 6105, p. 394-397 4 p.

Research output: Contribution to journalArticle

160 Scopus citations

Phosphoenolpyruvate carboxykinaseandglucose-6-phosphatase are required for steroidogenesis in testicular leydig cells

Ahn, S. W., Gang, G. T., Tadi, S., Nedumaran, B., Kim, Y. D., Park, J. H., Kweon, G. R., Koo, S. H., Lee, K., Ahn, R. S., Yim, Y. H., Lee, C. H., Harris, R. A. & Choi, H. S., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41875-41887 13 p.

Research output: Contribution to journalArticle

15 Scopus citations