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  • Lynda Bonewald
Article

ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass

Barreto, R., Kitase, Y., Matsumoto, T., Pin, F., Colston, K. C., Couch, K. E., O'Connell, T. M., Couch, M. E., Bonewald, L. F. & Bonetto, A., Dec 1 2017, In : Scientific reports. 7, 1, 14470.

Research output: Contribution to journalArticle

14 Scopus citations

A Novel Osteogenic Cell Line That Differentiates Into GFP-Tagged Osteocytes and Forms Mineral With a Bone-Like Lacunocanalicular Structure

Wang, K., Le, L., Chun, B. M., Tiede-Lewis, L. A. M., Shiflett, L. A., Prideaux, M., Campos, R. S., Veno, P. A., Xie, Y., Dusevich, V., Bonewald, L. F. & Dallas, S. L., Jun 2019, In : Journal of Bone and Mineral Research. 34, 6, p. 979-995 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Beta-catenin haplo insufficient male mice do not lose bone in response to hindlimb unloading

Maurel, D. B., Duan, P., Farr, J., Cheng, A. L., Johnson, M. L. & Bonewald, L., Jul 1 2016, In : PLoS One. 11, 7, e0158381.

Research output: Contribution to journalArticle

9 Scopus citations

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice

Essex, A. L., Pin, F., Huot, J. R., Bonewald, L. F., Plotkin, L. I. & Bonetto, A., Nov 19 2019, In : Frontiers in Endocrinology. 10, 809.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Medina-Gomez, C., Kemp, J. P., Dimou, N. L., Kreiner, E., Chesi, A., Zemel, B. S., Bønnelykke, K., Boer, C. G., Ahluwalia, T. S., Bisgaard, H., Evangelou, E., Heppe, D. H. M., Bonewald, L. F., Gorski, J. P., Ghanbari, M., Demissie, S., Duque, G., Maurano, M. T., Kiel, D. P., Hsu, Y. H. & 14 others, Van Der Eerden, B. C. J., Ackert-Bicknell, C., Reppe, S., Gautvik, K. M., Raastad, T., Karasik, D., Van De Peppel, J., Jaddoe, V. W. V., Uitterlinden, A. G., Tobias, J. H., Grant, S. F. A., Bagos, P. G., Evans, D. M. & Rivadeneira, F., Dec 1 2017, In : Nature communications. 8, 1, 121.

Research output: Contribution to journalArticle

26 Scopus citations

Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism

Yajima, A., Tsuchiya, K., Bonewald, L., Inaba, M., Tominaga, Y., Tanizawa, T., Ito, A. & Nitta, K., Feb 28 2018, (Accepted/In press) In : Osteoporosis International. p. 1-7 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Characterization of a novel murine Sost ER T2 Cre model targeting osteocytes

Maurel, D. B., Matsumoto, T., Vallejo, J. A., Johnson, M. L., Dallas, S. L., Kitase, Y., Brotto, M., Wacker, M. J., Harris, M. A., Harris, S. E. & Bonewald, L. F., Dec 1 2019, In : Bone Research. 7, 1, 6.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models

Sego, T. J., Prideaux, M., Sterner, J., McCarthy, B. P., Li, P., Bonewald, L. F., Ekser, B., Tovar, A. & Jeshua Smith, L., Mar 1 2020, In : Biotechnology and Bioengineering. 117, 3, p. 798-815 18 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Degeneration of the osteocyte network in the C57BL/6 mouse model of aging

Tiede-Lewis, L. A. M., Xie, Y., Hulbert, M. A., Campos, R., Dallas, M. R., Dusevich, V., Bonewald, L. F. & Dallas, S. L., Jan 1 2017, In : Aging. 9, 10, p. 2187-2205 19 p.

Research output: Contribution to journalArticle

30 Scopus citations

Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) gene in osteocytes stimulates soleus muscle regeneration and increased size and contractile force with age

Gorski, J. P., Huffman, N. T., Vallejo, J., Brotto, L., Chittur, S. V., Breggia, A., Stern, A., Huang, J., Mo, C., Seidah, N. G., Bonewald, L. & Brotto, M., Feb 26 2016, In : Journal of Biological Chemistry. 291, 9, p. 4308-4322 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes

Pacicca, D. M., Brown, T., Watkins, D., Kover, K., Yan, Y., Prideaux, M. & Bonewald, L., Dec 1 2019, In : Scientific reports. 9, 1, 17353.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells

Huang, J., Wang, K., Shiflett, L. A., Brotto, L., Bonewald, L. F., Wacker, M. J., Dallas, S. L. & Brotto, M., Dec 17 2019, In : Cell Cycle. 18, 24, p. 3562-3580 19 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers

Vemula, H., Kitase, Y., Ayon, N. J., Bonewald, L. & Gutheil, W. G., Jan 1 2017, In : Analytical biochemistry. 516, p. 75-85 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia

Pin, F., Barreto, R., Kitase, Y., Mitra, S., Erne, C. E., Novinger, L. J., Zimmers, T. A., Couch, M. E., Bonewald, L. F. & Bonetto, A., Aug 2018, In : Journal of Cachexia, Sarcopenia and Muscle. 9, 4, p. 685-700 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Hypoxia mediates osteocyte ORP150 expression and cell death in vitro

Montesi, M., Jähn, K., Bonewald, L., Stea, S., Bordini, B. & Beraudi, A., Nov 2016, In : Molecular Medicine Reports. 14, 5, p. 4248-4254 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of Senescent Cells in the Bone Microenvironment

Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L., Pignolo, R. J., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V. J. A., Novick, S. J., Strutzenberg, T. S., Pascal, B. D., Le, P. T., Brooks, D. J., Roche, A. M., Gerber, K. K., Mattheis, L., Chen, W., Tu, H., Bouxsein, M. L. & 5 others, Griffin, P. R., Baron, R., Rosen, C. J., Bonewald, L. F. & Spiegelman, B. M., Dec 13 2018, In : Cell. 175, 7, p. 1756-1768.e17

Research output: Contribution to journalArticle

58 Scopus citations

Isolation and Functional Analysis of an Immortalized Murine Cementocyte Cell Line, IDG-CM6

Zhao, N., Nociti, F. H., Duan, P., Prideaux, M., Zhao, H., Foster, B. L., Somerman, M. J. & Bonewald, L. F., Feb 1 2016, In : Journal of Bone and Mineral Research. 31, 2, p. 430-442 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs

Lu, Y., Kamel-El Sayed, S. A., Wang, K., Tiede-Lewis, L. A. M., Grillo, M. A., Veno, P. A., Dusevich, V., Phillips, C. L., Bonewald, L. F. & Dallas, S. L., Jun 2018, In : Journal of Bone and Mineral Research. 33, 6, p. 1166-1182 17 p.

Research output: Contribution to journalArticle

15 Scopus citations

Long-term bone regeneration, mineralization and angiogenesis in rat calvarial defects implanted with strong porous bioactive glass (13-93) scaffolds

Lin, Y., Xiao, W., Liu, X., Bal, B. S., Bonewald, L. & Rahaman, M. N., Jan 15 2016, In : Journal of Non-Crystalline Solids. 432, p. 120-129 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation

Morrell, A. E., Brown, G. N., Robinson, S. T., Sattler, R. L., Baik, A. D., Zhen, G., Cao, X., Bonewald, L. F., Jin, W., Kam, L. C. & Guo, X. E., Dec 1 2018, In : Bone Research. 6, 1, 6.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-ҡB activity

Miyazaki, T., Zhao, Z., Ichihara, Y., Yoshino, D., Imamura, T., Sawada, K., Hayano, S., Kamioka, H., Mori, S., Hirata, H., Araki, K., Kawauchi, K., Shigemoto, K., Tanaka, S., Bonewald, L. F., Honda, H., Shinohara, M., Nagao, M., Ogata, T., Harada, I. & 1 others, Sawada, Y., Sep 25 2019, In : Science Advances. 5, 9, eaau7802.

Research output: Contribution to journalArticle

Open Access

Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients

Pin, F., Bonetto, A., Bonewald, L. F. & Klein, G. L., Aug 7 2019, In : Frontiers in Endocrinology. 10, 543.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Multi-staged regulation of lipid signaling mediators during myogenesis by COX-1/2 pathways

Mo, C., Wang, Z., Bonewald, L. & Brotto, M., Sep 2019, In : International journal of molecular sciences. 20, 18, 4326.

Research output: Contribution to journalArticle

Open Access

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

Qin, Y., Peng, Y., Zhao, W., Pan, J., Ksiezak-Reding, H., Cardozo, C., Wu, Y., Pajevic, P. D., Bonewald, L. F., Bauman, W. A. & Qin, W., Jun 30 2017, In : Journal of Biological Chemistry. 292, 26, p. 11021-11033 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo

Jähn, K., Kelkar, S., Zhao, H., Xie, Y., Tiede-Lewis, L. A. M., Dusevich, V., Dallas, S. L. & Bonewald, L., Aug 1 2017, In : Journal of Bone and Mineral Research. 32, 8, p. 1761-1772 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression

Colditz, J., Thiele, S., Baschant, U., Niehrs, C., Bonewald, L. F., Hofbauer, L. C. & Rauner, M., Sep 2018, In : Journal of Bone and Mineral Research. 33, 9, p. 1698-1707 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition

Yamamoto, H., Ramos-Molina, B., Lick, A. N., Prideaux, M., Albornoz, V., Bonewald, L. & Lindberg, I., Mar 1 2016, In : Bone. 84, p. 120-130 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Proceedings of a Parent Project Muscular Dystrophy Bone Health Workshop: Morbidity due to osteoporosis in DMD: The Path Forward May 12–13, 2016, Bethesda, Maryland, USA

Parent Project Muscular Dystrophy Bone Health Workshop Collaborators, Jan 2018, In : Neuromuscular Disorders. 28, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Wang, Z., Bian, L., Mo, C., Shen, H., Zhao, L. J., Su, K. J., Kukula, M., Lee, J. T., Armstrong, D. W., Recker, R., Lappe, J., Bonewald, L. F., Deng, H. W. & Brotto, M., Dec 1 2020, In : Communications Biology. 3, 1, 39.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Skeletal muscle, but not cardiovascular function, is altered in a mouse model of autosomal recessive hypophosphatemic rickets

Wacker, M. J., Touchberry, C. D., Silswal, N., Brotto, L., Elmore, C. J., Bonewald, L., Andresen, J. & Brotto, M., 2016, In : Frontiers in Physiology. 7, MAY, 173.

Research output: Contribution to journalArticle

12 Scopus citations

Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/β-catenin signaling pathway

Prideaux, M., Kitase, Y., Kimble, M., O'Connell, T. M. & Bonewald, L. F., Aug 2020, In : Bone. 137, 115374.

Research output: Contribution to journalArticle

The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction

Wang, H., Li, T., Wang, X., Yin, X., Zhao, N., Zou, S., Duan, P. & Bonewald, L. F., Mar 12 2020, In : Biochemical and Biophysical Research Communications. 523, 3, p. 595-601 7 p.

Research output: Contribution to journalArticle

Use it or lose it to age: A review of bone and muscle communication

Bonewald, L., Mar 2019, In : Bone. 120, p. 212-218 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M. & Bonewald, L., Feb 6 2018, In : Cell Reports. 22, 6, p. 1531-1544 14 p.

Research output: Contribution to journalArticle

38 Scopus citations
Chapter

Osteocyte Biology

Bellido, T., Pajevic, P. D. & Bonewald, L., Jan 1 2018, Genetics of Bone Biology and Skeletal Disease: Second Edition. Elsevier Inc., p. 227-240 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteocytes

Bonewald, L., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 38-45 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The osteocyte

Klein-Nulend, J. & Bonewald, L. F., Jan 1 2019, Principles of Bone Biology. Elsevier, p. 133-162 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Comment/debate

Erratum: Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (Cell (2018) 175(7) (1756–1768.e17), (S0092867418313345), (10.1016/j.cell.2018.10.025))

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V. J. A., Novick, S. J., Strutzenberg, T. S., Pascal, B. D., Le, P. T., Brooks, D. J., Roche, A. M., Gerber, K. K., Mattheis, L., Chen, W., Tu, H., Bouxsein, M. L. & 5 others, Griffin, P. R., Baron, R., Rosen, C. J., Bonewald, L. F. & Spiegelman, B. M., Jul 11 2019, In : Cell. 178, 2, p. 507-508 2 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations
Conference contribution

Potential of bioact1ve glass scaffolds as implants for structural bone repair

Rahaman, M. N., Bal, B. S. & Bonewald, L., 2016, Advances in Bioceramics and Porous Ceramics VIII - A Collection of Papers Presented at the 39th International Conference on Advanced Ceramics and Composites. 5 ed. American Ceramic Society, Vol. 36. p. 3-15 13 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
Review article

Physiological and pathological osteocytic osteolysis

Tsourdi, E., Jähn, K., Rauner, M., Busse, B. & Bonewald, L. F., Sep 2018, In : Journal of Musculoskeletal Neuronal Interactions. 18, 3, p. 292-303 12 p.

Research output: Contribution to journalReview article

23 Scopus citations

The Cementocyte - An Osteocyte Relative?

Zhao, N., Foster, B. L. & Bonewald, L., Jul 1 2016, In : Journal of Dental Research. 95, 7, p. 734-741 8 p.

Research output: Contribution to journalReview article

11 Scopus citations

The Osteocyte: New Insights

Robling, A. G. & Bonewald, L. F., Jan 1 2020, In : Annual Review of Physiology. 82, p. 485-506 22 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

The Role of the Osteocyte in Bone and Nonbone Disease

Bonewald, L. F., Mar 1 2017, In : Endocrinology and Metabolism Clinics of North America. 46, 1, p. 1-18 18 p.

Research output: Contribution to journalReview article

39 Scopus citations
66 Scopus citations