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  • 2020
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  • Zhong-Yin Zhang

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Song, G. J., Jung, M., Kim, J. H., Park, H., Rahman, M. H., Zhang, S., Zhang, Z-Y., Park, D. H., Kook, H., Lee, I. K. & Suk, K., 2016, In : Journal of Neuroinflammation. 13, 1, 86.

Research output: Contribution to journalArticle

41 Scopus citations

Comparative analysis of protein tyrosine phosphatases regulating microglial activation

Song, G. J., Kim, J., Kim, J. H., Song, S., Park, H., Zhang, Z. Y. & Suk, K., Oct 1 2016, In : Experimental Neurobiology. 25, 5, p. 252-261 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Covalent inhibition of protein tyrosine phosphatases

Ruddraraju, K. V. & Zhang, Z. Y., Jan 1 2017, In : Molecular BioSystems. 13, 7, p. 1257-1279 23 p.

Research output: Contribution to journalReview article

12 Scopus citations

Current status of PTP-based therapeutics

He, R. & Zhang, Z-Y., Jan 1 2016, Protein Tyrosine Phosphatases in Cancer. Springer New York, p. 335-353 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Li, Y., Xia, G., Guo, Q., Wu, L., Chen, S., Yang, Z., Wang, W., Zhang, Z. Y., Zhou, X. & Jiang, Z. X., 2016, In : MedChemComm. 7, 8, p. 1672-1680 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z. Y. & Deng, Q., Mar 29 2018, In : Frontiers in immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery and evaluation of PRL trimer disruptors for novel anticancer agents

Bai, Y., Yu, Z. H. & Zhang, Z. Y., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1447. p. 121-138 18 p. (Methods in Molecular Biology; vol. 1447).

Research output: Chapter in Book/Report/Conference proceedingChapter

Drugging the undruggable: Therapeutic potential of targeting protein tyrosine phosphatases

Zhang, Z. Y., Jan 1 2017, In : Accounts of Chemical Research. 50, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells

Bai, S., Ingram, P., Chen, Y. C., Deng, N., Pearson, A., Niknafs, Y., O'Hayer, P., Wang, Y., Zhang, Z. Y., Boscolo, E., Bischoff, J., Yoon, E. & Buckanovich, R. J., Nov 1 2016, In : Cancer Research. 76, 21, p. 6396-6409 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z. Y., Gribble, G. W., Spinola, S. M. & Duerfeldt, A. S., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1836-1841 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

He, R., Wang, J., Yu, Z. H., Zhang, R. Y., Liu, S., Wu, L. & Zhang, Z. Y., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9094-9106 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus

Wang, J., Mizui, M., Zeng, L. F., Bronson, R., Finnell, M., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z. Y. & Kontaridis, M. I., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2077-2092 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z. Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., Sep 2018, In : eLife. 7, e38704.

Research output: Contribution to journalArticle

14 Scopus citations

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen

Dutta, N. K., He, R., Pinn, M. L., He, Y., Burrows, F., Zhang, Z. Y. & Karakousis, P. C., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

Hamerman, J. A., Pottle, J., Ni, M., He, Y., Zhang, Z. Y. & Buckner, J. H., Jan 1 2016, In : Immunological Reviews. 269, 1, p. 212-227 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

Bai, Y., Yu, Z. H., Liu, D. S., Zhang, L., Zhang, R. Y., Zeng, L. F., Zhang, S. & Zhang, Z. Y., Aug 15 2016, In : Cancer Research. 76, 16, p. 4805-4815 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H., Yoder, M., Kapur, R., Mulloy, J. C., Zhang, Z-Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia

Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z. Y. & Liu, Y., Mar 1 2017, In : Leukemia. 31, 3, p. 751-754 4 p.

Research output: Contribution to journalLetter

5 Scopus citations

Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

Yamashita, N., Joshi, R., Zhang, S., Zhang, Z. Y. & Kuruvilla, R., Sep 25 2017, In : Developmental Cell. 42, 6, p. 626-639.e5

Research output: Contribution to journalArticle

17 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Sacchetti, C., Bai, Y., Stanford, S. M., Di Benedetto, P., Cipriani, P., Santelli, E., Piera-Velazquez, S., Chernitskiy, V., Kiosses, W. B., Ceponis, A., Kaestner, K. H., Boin, F., Jimenez, S. A., Giacomelli, R., Zhang, Z. Y. & Bottini, N., Dec 1 2017, In : Nature communications. 8, 1, 1060.

Research output: Contribution to journalArticle

17 Scopus citations

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K. H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., Jan 15 2020, In : EMBO Journal. 39, 2, e103637.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Xu, J., Lee, S. S. Y., Seo, H., Pang, L., Jun, Y., Zhang, R. Y., Zhang, Z. Y., Kim, P., Lee, W., Kron, S. J. & Yeo, Y., Dec 13 2018, In : Small. 14, 50, 1803601.

Research output: Contribution to journalArticle

7 Scopus citations

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Yu, Z. H. & Zhang, Z-Y., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1069-1091 23 p.

Research output: Contribution to journalReview article

25 Scopus citations

Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis

Bai, Y., Zhou, H. M., Zhang, L., Dong, Y., Zeng, Q., Shou, W. & Zhang, Z. Y., Sep 26 2016, In : Scientific reports. 6, 34211.

Research output: Contribution to journalArticle

8 Scopus citations

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., Wang, Q., Shen, H., Yao, X., Zhang, Z. Y., Xue, S., Shen, L. & Cheng, J., 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Zhang, R. Y., Yu, Z. H., Zeng, L., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. & Zhang, Z. Y., Jan 1 2016, In : Oncotarget. 7, 45, p. 73817-73829 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, p. 783-792 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Small molecules target the interaction between tissue transglutaminase and fibronectin

Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N. G., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z. Y. & Matei, D., Jan 1 2019, In : Molecular cancer therapeutics. 18, 6, p. 1057-1068 12 p.

Research output: Contribution to journalArticle

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Oct 1 2016, In : Leukemia. 30, 10, p. 2094-2097 4 p.

Research output: Contribution to journalLetter

8 Scopus citations

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

McQueeney, K. E., Salamoun, J. M., Burnett, J. C., Barabutis, N., Pekic, P., Lewandowski, S. L., Llaneza, D. C., Cornelison, R., Bai, Y., Zhang, Z. Y., Catravas, J. D., Landen, C. N., Wipf, P., Lazo, J. S. & Sharlow, E. R., 2018, In : Oncotarget. 9, 9, p. 8223-8240 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Therapeutic targeting of oncogenic tyrosine phosphatases

Frankson, R., Yu, Z. H., Bai, Y., Li, Q., Zhang, R. Y. & Zhang, Z. Y., Nov 1 2017, In : Cancer Research. 77, 21, p. 5701-5705 5 p.

Research output: Contribution to journalReview article

34 Scopus citations

The tumor promoter-activated protein kinase Cs are a system for regulating filopodia

Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z-Y. & Boudreau, N. S., Aug 1 2017, In : Cytoskeleton. 74, 8, p. 297-314 18 p.

Research output: Contribution to journalArticle

1 Scopus citations

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Zehender, A., Huang, J., Györfi, A. H., Matei, A. E., Trinh-Minh, T., Xu, X., Li, Y. N., Chen, C. W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z. Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. & Distler, J. H. W., Dec 1 2018, In : Nature communications. 9, 1, 3259.

Research output: Contribution to journalArticle

14 Scopus citations

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A. & Dai, M., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17465-17473 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z. Y., Tsao, M. S., Ikura, M. & Ohh, M., Dec 1 2019, In : Nature communications. 10, 1, 224.

Research output: Contribution to journalArticle

8 Scopus citations