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  • G. David Roodman
2019

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Therapeutic targets in myeloma bone disease

Marino, S., Petrusca, D. N. & Roodman, G. D., Jan 1 2019, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalReview article

2 Scopus citations

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, D. G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., May 4 2018, In : Journal of Medical Economics. 21, 5, p. 525-536 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bones in Multiple Myeloma: Imaging and Therapy

Zamagni, E., Cavo, M., Fakhri, B., Vij, R. & Roodman, D., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 638-646 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Cancer and bone

Guise, T. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 737-738 2 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: An international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Jan 1 2018, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

86 Scopus citations

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Petrusca, D. N., Toscani, D., Wang, F. M., Park, C., Crean, C. D., Anderson, J. L., Marino, S., Mohammad, K. S., Zhou, D., Silbermann, R., Sun, Q., Kurihara, N., Galson, D. L., Giuliani, N. & Roodman, G. D., Oct 4 2018, In : Journal of Hematology and Oncology. 11, 1, 123.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanisms of osteolytic and osteoblastic skeletal lesions

Roodman, G. D. & Guise, T., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 739-742 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple myeloma and bone: The fatal interaction

Marino, S. & Roodman, G. D., Aug 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 8, a031286.

Research output: Contribution to journalArticle

5 Scopus citations

Osteoblast suppression in multiple myeloma bone disease

Adamik, J., Galson, D. L. & Roodman, G. D., Nov 2018, In : Journal of Bone Oncology. 13, p. 62-70 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

Paget disease of bone

Charles, J. F., Siris, E. S. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 713-720 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Primer on the metabolic bone diseases and disorders of mineral metabolism

Bilezikian, J. P., Bouillon, R., Clemens, T., Compston, J., Bauer, D. C., Ebeling, P. R., Engelke, K., Goltzman, D., Guise, T., Jan De Beur, S. M., Jüppner, H., Lyons, K., McCauley, L., McClung, M. R., Miller, P. D., Papapoulos, S. E., Roodman, G. D., Rosen, C. J., Seeman, E., Thakker, R. V. & 2 others, Whyte, M. P. & Zaidi, M., Jan 1 2018, wiley. 1105 p.

Research output: Book/ReportBook

1 Scopus citations

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Supportive care in multiple myeloma

Doshi, S. M., Noff, T. T. & David Roodman, G., Jan 1 2018, Neoplastic Diseases of the Blood. Springer International Publishing, p. 595-607 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

XRK3F2 inhibition of p62-ZZ domain signaling rescues myeloma-induced GFI1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression

Adamik, J., Silbermann, R., Marino, S., Sun, Q., Anderson, J. L., Zhou, D., Xie, X. Q., David Roodman, G. & Galson, D. L., Jun 29 2018, In : Frontiers in Endocrinology. 9, JUL, 344.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. A. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L. I., Bellido, T. & Roodman, G. D., Jan 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG

Hadji, P., Aapro, M. S., Body, J. J., Gnant, M., Brandi, M. L., Reginster, J. Y., Zillikens, M. C., Glüer, C. C., de Villiers, T., Baber, R., Roodman, G. D., Cooper, C., Langdahl, B., Palacios, S., Kanis, J., Al-Daghri, N., Nogues, X., Eriksen, E. F., Kurth, A., Rizzoli, R. & 1 others, Coleman, R. E., Jun 1 2017, In : Journal of Bone Oncology. 7, p. 1-12 12 p.

Research output: Contribution to journalReview article

67 Scopus citations

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma

Hao, M., Franqui-Machin, R., Xu, H., Shaughnessy, J., Barlogie, B., Roodman, D., Quelle, D. E., Janz, S., Tomasson, M. H., Sanderson, R. D., Qiu, L., Frech, I., Tricot, G. & Zhan, F., Jul 1 2017, In : Leukemia. 31, 7, p. 1648-1650 3 p.

Research output: Contribution to journalLetter

9 Scopus citations

Vitamin D and Paget's Disease

Kurihara, N. & Roodman, G. D., Dec 14 2017, Health, Disease and Therapeutics. Elsevier Inc., Vol. 2. p. 571-579 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016
72 Scopus citations

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K. S., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Bone disease in multiple myeloma

Eda, H., Santo, L., Roodman, G. D. & Raje, N., Jan 1 2016, Cancer Treatment and Research. Kluwer Academic Publishers, p. 251-270 20 p. (Cancer Treatment and Research; vol. 169).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Current Controversies in the Management of Myeloma Bone Disease

Silbermann, R. & Roodman, G. D., Nov 1 2016, In : Journal of cellular physiology. 231, 11, p. 2374-2379 6 p.

Research output: Contribution to journalReview article

15 Scopus citations

Developmental Aspects of Pagetic Osteoclasts

Galson, D. L., Sun, Q. & Roodman, G. D., May 9 2016, Advances in Pathobiology and Management of Paget's Disease of Bone. Elsevier Inc., p. 37-53 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

34 Scopus citations

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

Storti, P., Marchica, V., Airoldi, I., Donofrio, G., Fiorini, E., Ferri, V., Guasco, D., Todoerti, K., Silbermann, R., Anderson, J. L., Zhao, W., Agnelli, L., Bolzoni, M., Martella, E., Mancini, C., Campanini, N., Noonan, D. M., Petronini, P. G., Neri, A., Aversa, F. & 2 others, Roodman, G. D. & Giuliani, N., Dec 1 2016, In : Leukemia. 30, 12, p. 2351-2363 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease

Teramachi, J., Nagata, Y., Mohammad, K., Inagaki, Y., Ohata, Y., Guise, T., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N. & Roodman, G. D., Mar 1 2016, In : Journal of Clinical Investigation. 126, 3, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

The Role of the Immune System in the Effects of Cancer on Bone

Silbermann, R. & David Roodman, G., Jan 1 2016, Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc., p. 311-324 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter