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  • Naga Chalasani
2020

Alcohol Rehabilitation Within 30 Days of Hospital Discharge Is Associated With Reduced Readmission, Relapse, and Death in Patients With Alcoholic Hepatitis

Peeraphatdit, T. B., Kamath, P. S., Karpyak, V. M., Davis, B., Desai, V., Liangpunsakul, S., Sanyal, A., Chalasani, N., Shah, V. H. & Simonetto, D. A., Feb 2020, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 477-485.e5

Research output: Contribution to journalArticle

2 Scopus citations

Apolipoprotein B and PNPLA3 Double Heterozygosity in a Father–Son Pair With Advanced Nonalcoholic Fatty Liver Disease

Jansson-Knodell, C. L., Gawrieh, S., McIntyre, A. D., Liang, T., Hegele, R. A. & Chalasani, N., Jan 1 2020, In : Hepatology. 71, 1, p. 383-385 3 p.

Research output: Contribution to journalArticle

Automated quantification and architectural pattern detection of hepatic fibrosis in NAFLD

Gawrieh, S., Sethunath, D., Cummings, O. W., Kleiner, D. E., Vuppalanchi, R., Chalasani, N. & Tuceryan, M., Aug 2020, In : Annals of Diagnostic Pathology. 47, 151518.

Research output: Contribution to journalArticle

Clinical Characteristics and Adverse Impact of Hepatotoxicity due to Immune Checkpoint Inhibitors

Miller, E. D., Abu-Sbeih, H., Styskel, B., Nogueras Gonzalez, G. M., Blechacz, B., Naing, A. & Chalasani, N., Feb 1 2020, In : The American journal of gastroenterology. 115, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Consensus guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic cholestatic liver disease

Palmer, M., Regev, A., Lindor, K., Avigan, M. I., Dimick-Santos, L., Treem, W., Marcinak, J. F., Lewis, J. H., Anania, F. A., Seekins, D., Shneider, B. L. & Chalasani, N., Jan 1 2020, In : Alimentary Pharmacology and Therapeutics. 51, 1, p. 90-109 20 p.

Research output: Contribution to journalReview article

Open Access

Distinctive Features and Outcomes of Hepatocellular Carcinoma in Patients With Alcohol-Related Liver Disease: A US Multicenter Study

deLemos, A., Patel, M., Gawrieh, S., Burney, H., Dakhoul, L., Miller, E., Scanga, A., Kettler, C., Liu, H., Roche, P., Wattacheril, J. & Chalasani, N., Mar 1 2020, In : Clinical and translational gastroenterology. 11, 3, p. e00139

Research output: Contribution to journalArticle

Open Access

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

The Belapectin (GR-MD-02) Study Investigators, Apr 2020, In : Gastroenterology. 158, 5, p. 1334-1345.e5

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access

Persistent Hyperactivation of Endothelial Cells in Patients with Alcoholic Hepatitis

Xia, Y., Yang, J., Sanyal, A. J., Shah, V. H., Chalasani, N. P., Yu, Q., Zheng, X. & Li, W., May 1 2020, In : Alcoholism: Clinical and Experimental Research. 44, 5, p. 1075-1087 13 p.

Research output: Contribution to journalArticle

Significant Medical Comorbidities Are Associated With Lower Causality Scores in Patients Presenting With Suspected Drug-Induced Liver Injury

Ghabril, M., Gu, J., Yoder, L., Corbito, L., Dakhoul, L., Ringel, A., Beyer, C. D., Vuppalanchi, R., Barnhart, H., Hayashi, P. H. & Chalasani, N., Apr 1 2020, In : Clinical and translational gastroenterology. 11, 4, p. e00141

Research output: Contribution to journalArticle

Open Access

Spontaneous Fluctuations in Liver Biochemistries in Patients with Compensated NASH Cirrhosis: Implications for Drug Hepatotoxicity Monitoring

Shamseddeen, H., Vilar-Gomez, E., Chalasani, N., Myers, R. P., Subramanian, G. M., Shlevin, H. H., Allgood, A. E. & Orman, E. S., Mar 1 2020, In : Drug Safety. 43, 3, p. 281-290 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2018

A dedicated paracentesis clinic decreases healthcare utilization for serial paracenteses in decompensated cirrhosis

Cheng, Y. W., Sandrasegaran, K., Cheng, K., Shah, A., Ghabril, M., Berry, W., Lammert, C., Chalasani, N. & Orman, E. S., Aug 1 2018, In : Abdominal Radiology. 43, 8, p. 2190-2197 8 p.

Research output: Contribution to journalArticle

Automated assessment of steatosis in murine fatty liver

Sethunath, D., Morusu, S., Tuceryan, M., Cummings, O., Zhang, H., Yin, X-M., Vanderbeck, S., Chalasani, N. & Gawrieh, S., May 1 2018, In : PLoS One. 13, 5, e0197242.

Research output: Contribution to journalArticle

1 Scopus citations

Celecoxib-induced Liver Injury

Mukthinuthalapati, P. K., Fontana, R. J., Vuppalanchi, R., Chalasani, N. & Ghabril, M., Jan 1 2018, In : Journal of Clinical Gastroenterology. 52, 2, p. 114-122 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

Class II Human Leukocyte Antigen Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation After Liver Transplantation

Kubal, C. A., Mangus, R., Ekser, B., Mihaylov, P., Ceballos, B., Higgins, N., Chalasani, N., Ghabril, M., Nephew, L. & Lobashevsky, A., Aug 2018, In : Liver Transplantation. 24, 8, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis

for the NASH CRN, Mar 2018, In : Alimentary Pharmacology and Therapeutics. 47, 5, p. 645-656 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis

Kowalec, K., Wright, G. E. B., Drögemöller, B. I., Aminkeng, F., Bhavsar, A. P., Kingwell, E., Yoshida, E. M., Traboulsee, A., Marrie, R. A., Kremenchutzky, M., Campbell, T. L., Duquette, P., Chalasani, N., Wadelius, M., Hallberg, P., Xia, Z., De Jager, P. L., Denny, J. C., Davis, M. F., Ross, C. J. D. & 2 others, Tremlett, H. & Carleton, B. C., Aug 1 2018, In : Nature genetics. 50, 8, p. 1081-1085 5 p.

Research output: Contribution to journalLetter

13 Scopus citations

Concomitant Psychiatric and Nonalcohol-Related Substance Use Disorders Among Hospitalized Patients with Alcoholic Liver Disease in the United States

the Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium, Feb 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 2, p. 397-402 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Younossi, Z. M., Loomba, R., Rinella, M. E., Bugianesi, E., Marchesini, G., Neuschwander-Tetri, B. A., Serfaty, L., Negro, F., Caldwell, S. H., Ratziu, V., Corey, K. E., Friedman, S. L., Abdelmalek, M. F., Harrison, S. A., Sanyal, A. J., Lavine, J. E., Mathurin, P., Charlton, M. R., Chalasani, N. P., Anstee, Q. M. & 4 others, Kowdley, K. V., George, J., Goodman, Z. D. & Lindor, K., Jul 2018, In : Hepatology. 68, 1, p. 361-371 11 p.

Research output: Contribution to journalReview article

95 Scopus citations

Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group

Bonkovsky, H. L., Barnhart, H. X., Foureau, D. M., Steuerwald, N., Lee, W. M., Gu, J., Fontana, R. J., Hayashi, P. J., Chalasani, N., Navarro, V. M., Odin, J., Stolz, A., Watkins, P. B. & Serrano, J., Oct 2018, In : PloS one. 13, 10, e0206389.

Research output: Contribution to journalArticle

8 Scopus citations

Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

Younossi, Z. M., Loomba, R., Anstee, Q. M., Rinella, M. E., Bugianesi, E., Marchesini, G., Neuschwander-Tetri, B. A., Serfaty, L., Negro, F., Caldwell, S. H., Ratziu, V., Corey, K. E., Friedman, S. L., Abdelmalek, M. F., Harrison, S. A., Sanyal, A. J., Lavine, J. E., Mathurin, P., Charlton, M. R., Goodman, Z. D. & 4 others, Chalasani, N. P., Kowdley, K. V., George, J. & Lindor, K., Jul 2018, In : Hepatology. 68, 1, p. 349-360 12 p.

Research output: Contribution to journalReview article

96 Scopus citations

Drug-induced chronic liver injury

Dakhoul, L., Ghabril, M. & Chalasani, N., Jul 2018, In : Journal of Hepatology. 69, 1, p. 248-250 3 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply

Zhang, H., Yan, S., Khambu, B., Ma, F., Li, Y., Chen, X., Martina, J. A., Puertollano, R., Li, Y., Chalasani, N. & Yin, X. M., Oct 3 2018, In : Autophagy. 14, 10, p. 1779-1795 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Emerging Treatments for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

Gawrieh, S. & Chalasani, N., Feb 2018, In : Clinics in Liver Disease. 22, 1, p. 189-199 11 p.

Research output: Contribution to journalReview article

13 Scopus citations

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study

Vilar-Gomez, E., Calzadilla-Bertot, L., Wai-Sun Wong, V., Castellanos, M., Aller-de la Fuente, R., Metwally, M., Eslam, M., Gonzalez-Fabian, L., Alvarez-Quiñones Sanz, M., Conde-Martin, A. F., De Boer, B., McLeod, D., Hung Chan, A. W., Chalasani, N., George, J., Adams, L. A. & Romero-Gomez, M., Aug 2018, In : Gastroenterology. 155, 2, p. 443-457.e17

Research output: Contribution to journalArticle

98 Scopus citations

Genetic Variants Associated with Obesity and Insulin Resistance in Hispanic Boys with Nonalcoholic Fatty Liver Disease

Rausch, J. C., Lavine, J. E., Chalasani, N., Guo, X., Kwon, S., Schwimmer, J. B., Molleston, J. P., Loomba, R., Brunt, E. M., Chen, Y. D. I., Goodarzi, M. O., Taylor, K. D., Yates, K. P. & Rotter, J. I., May 1 2018, In : Journal of pediatric gastroenterology and nutrition. 66, 5, p. 789-796 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers

United States Drug Induced Liver Injury Network, May 2018, In : Clinical Gastroenterology and Hepatology. 16, 5, p. 722-729.e2

Research output: Contribution to journalArticle

6 Scopus citations

Hospital readmissions in patients with cirrhosis: A systematic review

Orman, E. S., Ghabril, M., Emmett, T. W. & Chalasani, N., Jul 2018, In : Journal of hospital medicine. 13, 7, p. 490-495 6 p.

Research output: Contribution to journalReview article

16 Scopus citations

In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children

Nobili, V., Alisi, A., Liu, Z., Liang, T., Crudele, A., Raponi, M., Lin, J., Chalasani, N. P. & Liu, W., Nov 1 2018, In : Pediatric Research. 84, 5, p. 696-703 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Laboratory tests in liver disease

Vuppalanchi, R. & Chalasani, N., Jan 1 2018, Practical Hepatic Pathology: A Diagnostic Approach: Second Edition. Elsevier, p. 43-53 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Leveraging social networking sites for an autoimmune hepatitis genetic repository: Pilot study to evaluate feasibility

Comerford, M., Fogel, R., Bailey, J. R., Chilukuri, P., Chalasani, N. & Lammert, C. S., Jan 1 2018, In : Journal of Medical Internet Research. 20, 1, e14.

Research output: Contribution to journalArticle

4 Scopus citations

Liver Stiffness Measurements in Patients with Noncirrhotic Portal Hypertension—The Devil Is in the Details

Vuppalanchi, R., Mathur, K., Pyko, M., Samala, N. & Chalasani, N., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

9 Scopus citations

Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development

Lubecka, K., Flower, K., Beetch, M., Qiu, J., Kurzava, L., Buvala, H., Ruhayel, A., Gawrieh, S., Liangpunsakul, S., Gonzalez, T., McCabe, G., Chalasani, N., Flanagan, J. M. & Stefanska, B., Jun 3 2018, In : Epigenetics. 13, 6, p. 605-626 22 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lower expression of tumor microRNA-26a is associated with higher recurrence in patients with hepatocellular carcinoma undergoing surgical treatment

Jones, K. R., Nabinger, S. C., Lee, S., Sahu, S. S., Althouse, S., Saxena, R., Johnson, M. S., Chalasani, N., Gawrieh, S. & Kota, J., Sep 1 2018, In : Journal of Surgical Oncology. 118, 3, p. 431-439 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers

Vilar-Gomez, E. & Chalasani, N., Feb 2018, In : Journal of Hepatology. 68, 2, p. 305-315 11 p.

Research output: Contribution to journalReview article

89 Scopus citations

Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease

for the NASH Clinical Research Network, Jan 2018, In : Hepatology. 67, 1, p. 134-144 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis

Samala, N., Lourens, S. G., Shah, V. H., Kamath, P. S., Sanyal, A. J., Crabb, D. W., Tang, Q., Radaeva, S., Liangpunsakul, S. & Chalasani, N., Oct 2018, In : Alcoholism: Clinical and Experimental Research. 42, 10, p. 1933-1938 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

Chalasani, N., Vuppalanchi, R., Rinella, M., Middleton, M. S., Siddiqui, M. S., Barritt, A. S., Kolterman, O., Flores, O., Alonso, C., Iruarrizaga-Lejarreta, M., Gil-Redondo, R., Sirlin, C. B. & Zemel, M. B., Jun 2018, In : Alimentary Pharmacology and Therapeutics. 47, 12, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Reply

on behalf of the Writing Group for the AASLD NAFLD Practice Gudiance, Jun 2018, In : Hepatology. 67, 6, p. 2478-2479 2 p.

Research output: Contribution to journalLetter

1 Scopus citations

Targeting incretin hormones and the ASK-1 pathway as therapeutic options in the treatment of non-alcoholic steatohepatitis

Kovalic, A. J., Satapathy, S. K. & Chalasani, N., Mar 1 2018, In : Hepatology International. 12, 2, p. 97-106 10 p.

Research output: Contribution to journalReview article

7 Scopus citations

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

for the TREAT Consortium, Apr 2018, In : Hepatology. 67, 4, p. 1284-1302 19 p.

Research output: Contribution to journalArticle

31 Scopus citations

The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine

Fontana, R. J., Cirulli, E. T., Gu, J., Kleiner, D., Ostrov, D., Phillips, E., Schutte, R., Barnhart, H., Chalasani, N., Watkins, P. B. & Hoofnagle, J. H., Dec 2018, In : Journal of Hepatology. 69, 6, p. 1317-1325 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

The rs626283 variant in the MBOAT7 gene is associated with insulin resistance and fatty liver in Caucasian obese youth

Umano, G. R., Caprio, S., Di Sessa, A., Chalasani, N., Dykas, D. J., Pierpont, B., Bale, A. E. & Santoro, N., Mar 2018, In : American Journal of Gastroenterology. 113, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study

Li, W., Amet, T., Xing, Y., Yang, D., Liangpunsakul, S., Puri, P., Kamath, P. S., Sanyal, A. J., Shah, V. H., Katz, B. P., Radaeva, S., Crabb, D. W., Chalasani, N. & Yu, Q., Aug 2017, In : Hepatology. 66, 2, p. 575-590 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis

for the TREAT Consortium, Nov 2 2017, In : Scandinavian Journal of Gastroenterology. 52, 11, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium, Apr 1 2017, In : Gastroenterology. 152, 5, p. 1078-1089 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

Azathioprine and 6-Mercaptopurine-induced Liver Injury

DILIN Investigators, 2017, In : Journal of Clinical Gastroenterology. 51, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Causality Assessment for Suspected Drug-Induced Liver Injury in Patients With Underlying Chronic Liver Disease

Dakhoul, L. & Chalasani, N., Mar 1 2017, In : Clinical Liver Disease. 9, 3, p. 63-65 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

Challenges in Patient Enrollment and Retention in Clinical Studies for Alcoholic Hepatitis: Experience of the TREAT Consortium

Comerford, M., Lourens, S., Liangpunsakul, S., Chalasani, N. P., Sanyal, A. J., Shah, V. H., Kamath, P. S., Puri, P., Katz, B. P., Radaeva, S. & Crabb, D. W., Dec 2017, In : Alcoholism: Clinical and Experimental Research. 41, 12, p. 2000-2006 7 p.

Research output: Contribution to journalReview article

3 Scopus citations