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  • Andrew Saykin
2020

Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study

Chen, B. T., Ye, N., Wong, C. W., Patel, S. K., Jin, T., Sun, C. L., Rockne, R. C., Kim, H., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Prakash, N., Mortimer, J., Sedrak, M. S., Waisman, J., Yuan, Y., Li, D., Vazquez, J., Katheria, V. & 1 others, Dale, W., Mar 2020, In : Journal of Geriatric Oncology. 11, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Elevated Cerebrospinal Fluid Tau Protein Concentrations on Admission Are Associated with Long-term Neurologic and Cognitive Impairment in Ugandan Children with Cerebral Malaria

Datta, D., Conroy, A. L., Castelluccio, P. F., Ssenkusu, J. M., Park, G. S., Opoka, R. O., Bangirana, P., Idro, R., Saykin, A. J. & John, C. C., Mar 3 2020, In : Clinical Infectious Diseases. 70, 6, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

The Alzheimer’s Disease Genetics Consortium, Dec 1 2020, In : Nature communications. 11, 1, 667.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

The Alzheimer Disease Neuroimaging Initiative, Dec 1 2020, In : Nature communications. 11, 1, 411.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2020, In : Nature communications. 11, 1, 347.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

the Alzheimer's Disease Genetics Consortium, Aug 1 2020, In : Alzheimer's and Dementia. 16, 8, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

Nho, K., Nudelman, K., Allen, M., Hodges, A., Kim, S., Risacher, S. L., Apostolova, L. G., Lin, K., Lunnon, K., Wang, X., Burgess, J. D., Ertekin-Taner, N., Petersen, R. C., Wang, L., Qi, Z., He, A., Neuhaus, I., Patel, V., Foroud, T., Faber, K. M. & 4 others, Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 2020, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Vasanthakumar, A., Davis, J. W., Idler, K., Waring, J. F., Asque, E., Riley-Gillis, B., Grosskurth, S., Srivastava, G., Kim, S., Kim, S., Nho, K., Nudelman, K. N. H., Nudelman, K. N. H., Faber, K., Sun, Y., Sun, Y., Foroud, T. M., Estrada, K., Estrada, K., Apostolova, L. G. & 3 others, Li, Q. S., Li, Q. S. & Saykin, A. J., Jun 15 2020, In : Clinical Epigenetics. 12, 1, 84.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso

Xie, L., Varathan, P., Nho, K., Saykin, A. J., Salama, P. & Yan, J., Jun 2020, In : PloS one. 15, 6, e0234748.

Research output: Contribution to journalArticle

Open Access

Identifying diagnosis-specific genotype-phenotype associations via joint multitask sparse canonical correlation analysis and classification

Alzheimer’s Disease Neuroimaging Initiative, Jul 1 2020, In : Bioinformatics (Oxford, England). 36, 1, p. i371-i379

Research output: Contribution to journalArticle

Open Access

Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene

Soheili-Nezhad, S., Jahanshad, N., Guelfi, S., Khosrowabadi, R., Saykin, A. J., Thompson, P. M., Beckmann, C. F., Sprooten, E. & Zarei, M., Sep 1 2020, In : Human Brain Mapping. 41, 13, p. 3737-3748 12 p.

Research output: Contribution to journalArticle

Open Access

Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study

Wu, Y. C., Harezlak, J., Elsaid, N. M. H., Lin, Z., Wen, Q., Mustafi, S. M., Riggen, L. D., Koch, K. M., Nencka, A. S., Meier, T. B., Mayer, A. R., Wang, Y., Giza, C. C., DiFiori, J. P., Guskiewicz, K. M., Mihalik, J. P., LaConte, S. M., Duma, S. M., Broglio, S. P., Saykin, A. J. & 2 others, McCrea, M. A. & McAllister, T. W., Aug 18 2020, In : Neurology. 95, 7, p. e781-e792

Research output: Contribution to journalArticle

Open Access

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Chopra, N., Wang, R., Maloney, B., Nho, K., Beck, J. S., Pourshafie, N., Niculescu, A., Saykin, A. J., Rinaldi, C., Counts, S. E. & Lahiri, D. K., 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multi-modal neuroimaging feature selection with consistent metric constraint for diagnosis of Alzheimer's disease

for the Alzheimer's Disease Neuroimaging Initiative, Feb 2020, In : Medical Image Analysis. 60, 101625.

Research output: Contribution to journalArticle

4 Scopus citations

Neurodegenerative changes in early-and late-onset cognitive impairment with and without brain amyloidosis

Stage, E. C., Svaldi, D., Phillips, M., Canela, V. H., Duran, T., Goukasian, N., Risacher, S. L., Saykin, A. J. & Apostolova, L. G., Aug 5 2020, In : Alzheimer's Research and Therapy. 12, 1, 93.

Research output: Contribution to journalArticle

Open Access

Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer's Disease Subjects: Evidence for Disease Heterogeneity

Phillips, M. L., Stage, E. C., Lane, K. A., Gao, S., Risacher, S. L., Goukasian, N., Saykin, A. J., Carrillo, M. C., DIckerson, B. C., Rabinovici, G. D. & Apostolova, L. G., Feb 1 2020, In : Dementia and Geriatric Cognitive Disorders. 48, 3-4, p. 131-142 12 p.

Research output: Contribution to journalArticle

Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia

Callahan, C. M., Apostolova, L. G., Gao, S., Risacher, S. L., Case, J., Saykin, A. J., Lane, K. A., Swinford, C. G. & Yoder, M. C., 2020, In : Journal of Alzheimer's Disease. 75, 3, p. 959-969 11 p.

Research output: Contribution to journalArticle

Regional imaging genetic enrichment analysis

Yao, X., Cong, S., Yan, J., Risacher, S. L., Saykin, A. J., Moore, J. H. & Shen, L., Apr 15 2020, In : Bioinformatics. 36, 8, p. 2554-2560 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Resting-state fMRI metrics in acute sport-related concussion and their association with clinical recovery: A study from the NCAA-DOD CARE consortium

Meier, T. B., Giraldo-Chica, M., España, L. Y., Mayer, A. R., Harezlak, J., Nencka, A. S., Wang, Y., Koch, K. M., Wu, Y. C., Saykin, A. J., Giza, C. C., Goldman, J., Difiori, J. P., Guskiewicz, K. M., Mihalik, J. P., Brooks, A., Broglio, S. P., McAllister, T. & McCrea, M. A., Jan 1 2020, In : Journal of neurotrauma. 37, 1, p. 152-162 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network, Aug 2020, In : Neurobiology of Disease. 142, 104960.

Research output: Contribution to journalArticle

Open Access

Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers

Alzheimer's Disease Neuroimaging Initiative and Alzheimer's Disease Metabolomics Consortium, May 19 2020, In : Neurology. 94, 20, p. e2088-e2098

Research output: Contribution to journalArticle

2 Scopus citations

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., John-Williams, L. S., Tenenbaum, J. D., Blach, C., Chang, R., Brinton, R. D., Baillie, R., Han, X., Trojanowski, J. Q., Shaw, L. M., Martins, R. & 10 others, Weiner, M. W., Trushina, E., Toledo, J. B., Meikle, P. J., Bennett, D. A., Krumsiek, J., Doraiswamy, P. M., Saykin, A. J., Kaddurah-Daouk, R. & Kastenmüller, G., Dec 1 2020, In : Nature communications. 11, 1, 1148.

Research output: Contribution to journalArticle

Open Access

Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study

Mandelblatt, J. S., Zhai, W., Ahn, J., Small, B. J., Ahles, T. A., Carroll, J. E., Denduluri, N., Dilawari, A., Extermann, M., Graham, D., Hurria, A., Isaacs, C., Jacobsen, P. B., Jim, H. S. L., Luta, G., McDonald, B. C., Patel, S. K., Root, J. C., Saykin, A. J., Tometich, D. B. & 2 others, Zhou, X. & Cohen, H. J., Mar 15 2020, In : Cancer. 126, 6, p. 1183-1192 10 p.

Research output: Contribution to journalArticle

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease

the Alzheimer's Disease Neuroimaging Initiative (ADNI), 2020, In : NeuroImage: Clinical. 26, 102203.

Research output: Contribution to journalArticle

Open Access

Testing influences of APOE and BDNF genes and heart failure on cognitive function

Jung, M., Apostolova, L. G., Gao, S., Burney, H. N., Lai, D., Foroud, T., Saykin, A. J. & Pressler, S. J., 2020, (Accepted/In press) In : Heart and Lung.

Research output: Contribution to journalArticle

The Association Between Persistent White-Matter Abnormalities and Repeat Injury After Sport-Related Concussion

Brett, B. L., Wu, Y. C., Mustafi, S. M., Saykin, A. J., Koch, K. M., Nencka, A. S., Giza, C. C., Goldman, J., Guskiewicz, K. M., Mihalik, J. P., Duma, S. M., Broglio, S. P., McAllister, T. W., McCrea, M. A. & Meier, T. B., Jan 21 2020, In : Frontiers in Neurology. 10, 1345.

Research output: Contribution to journalArticle

Open Access

The characterisation of subjective cognitive decline

Jessen, F., Amariglio, R. E., Buckley, R. F., van der Flier, W. M., Han, Y., Molinuevo, J. L., Rabin, L., Rentz, D. M., Rodriguez-Gomez, O., Saykin, A. J., Sikkes, S. A. M., Smart, C. M., Wolfsgruber, S. & Wagner, M., Mar 2020, In : The Lancet Neurology. 19, 3, p. 271-278 8 p.

Research output: Contribution to journalReview article

13 Scopus citations

The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group, Mar 20 2020, In : Science. 367, 6484, aay6690.

Research output: Contribution to journalArticle

29 Scopus citations

Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data

UK Brain Expression Consortium & Alzheimer's Disease Neuroimaging Initiative, Nov 2020, In : Neurobiology of Aging. 95, p. 81-93 13 p.

Research output: Contribution to journalArticle

Open Access