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  • Zhong-Yin Zhang

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Covalent inhibition of protein tyrosine phosphatases

Ruddraraju, K. V. & Zhang, Z. Y., Jan 1 2017, In : Molecular BioSystems. 13, 7, p. 1257-1279 23 p.

Research output: Contribution to journalReview article

15 Scopus citations

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z. Y. & Deng, Q., Mar 29 2018, In : Frontiers in immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

6 Scopus citations

Drugging the undruggable: Therapeutic potential of targeting protein tyrosine phosphatases

Zhang, Z. Y., Jan 1 2017, In : Accounts of Chemical Research. 50, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z. Y., Gribble, G. W., Spinola, S. M. & Duerfeldt, A. S., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1836-1841 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z. Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., Sep 2018, In : eLife. 7, e38704.

Research output: Contribution to journalArticle

15 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H. S., Yoder, M. C., Kapur, R., Mulloy, J. C., Zhang, Z. Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia

Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z. Y. & Liu, Y., Mar 1 2017, In : Leukemia. 31, 3, p. 751-754 4 p.

Research output: Contribution to journalLetter

5 Scopus citations

Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

Yamashita, N., Joshi, R., Zhang, S., Zhang, Z. Y. & Kuruvilla, R., Sep 25 2017, In : Developmental Cell. 42, 6, p. 626-639.e5

Research output: Contribution to journalArticle

17 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Sacchetti, C., Bai, Y., Stanford, S. M., Di Benedetto, P., Cipriani, P., Santelli, E., Piera-Velazquez, S., Chernitskiy, V., Kiosses, W. B., Ceponis, A., Kaestner, K. H., Boin, F., Jimenez, S. A., Giacomelli, R., Zhang, Z. Y. & Bottini, N., Dec 1 2017, In : Nature communications. 8, 1, 1060.

Research output: Contribution to journalArticle

19 Scopus citations

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K. H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., Jan 15 2020, In : EMBO Journal. 39, 2, e103637.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Xu, J., Lee, S. S. Y., Seo, H., Pang, L., Jun, Y., Zhang, R. Y., Zhang, Z. Y., Kim, P., Lee, W., Kron, S. J. & Yeo, Y., Dec 13 2018, In : Small. 14, 50, 1803601.

Research output: Contribution to journalArticle

8 Scopus citations

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Yu, Z. H. & Zhang, Z-Y., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1069-1091 23 p.

Research output: Contribution to journalReview article

28 Scopus citations

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., Wang, Q., Shen, H., Yao, X., Zhang, Z. Y., Xue, S., Shen, L. & Cheng, J., 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Small molecules target the interaction between tissue transglutaminase and fibronectin

Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N. G., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z. Y. & Matei, D., Jan 1 2019, In : Molecular cancer therapeutics. 18, 6, p. 1057-1068 12 p.

Research output: Contribution to journalArticle

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

McQueeney, K. E., Salamoun, J. M., Burnett, J. C., Barabutis, N., Pekic, P., Lewandowski, S. L., Llaneza, D. C., Cornelison, R., Bai, Y., Zhang, Z. Y., Catravas, J. D., Landen, C. N., Wipf, P., Lazo, J. S. & Sharlow, E. R., 2018, In : Oncotarget. 9, 9, p. 8223-8240 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Therapeutic targeting of oncogenic tyrosine phosphatases

Frankson, R., Yu, Z. H., Bai, Y., Li, Q., Zhang, R. Y. & Zhang, Z. Y., Nov 1 2017, In : Cancer Research. 77, 21, p. 5701-5705 5 p.

Research output: Contribution to journalReview article

36 Scopus citations

The tumor promoter-activated protein kinase Cs are a system for regulating filopodia

Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z. Y. & Boudreau, N. S., Aug 2017, In : Cytoskeleton. 74, 8, p. 297-314 18 p.

Research output: Contribution to journalArticle

1 Scopus citations

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Zehender, A., Huang, J., Györfi, A. H., Matei, A. E., Trinh-Minh, T., Xu, X., Li, Y. N., Chen, C. W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z. Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. & Distler, J. H. W., Dec 1 2018, In : Nature communications. 9, 1, 3259.

Research output: Contribution to journalArticle

16 Scopus citations

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A. & Dai, M., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17465-17473 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z. Y., Tsao, M. S., Ikura, M. & Ohh, M., Dec 1 2019, In : Nature communications. 10, 1, 224.

Research output: Contribution to journalArticle

12 Scopus citations