A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism

Marc A. Schuckit, Tom L. Smith, George Danko, John Kramer, Kathleen K. Bucholz, Vivia Mccutcheon, Grace Chan, Samuel Kuperman, Victor Hesselbrock, Danielle M. Dick, Michie Hesselbrock, Bernice Porjesz, Howard Edenberg, John I. Nureberger, Marcy Gregg, Lara Schoen, Mari Kawamura, Lee Anne Mendoza

Research output: Contribution to journalArticle

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Abstract

Background: Recent reports indicate higher-than-expected problematic drinking in older populations. However, few data describe how to predict which older individuals are most likely to demonstrate alcohol-related problems, including those with earlier alcohol use disorders (AUDs). These analyses evaluate predictors of alcohol outcomes in individuals with earlier AUDs in the Collaborative Study on Genetics of Alcoholism (COGA). Methods: Original COGA participants with baseline AUDs at about age 40 were interviewed 13 to 26 years later and placed into clinically derived outcome categories. Chi-square and analysis of variance evaluated baseline differences across 4 outcome groups, with significant items entered into binary logistic regression backwards elimination analyses predicting outcomes. Results: Low-Risk Drinkers (N = 100) at follow-up were predicted by baseline higher levels of response to alcohol (high LRs), lower histories of alcohol treatment, experience with fewer types of illicit drugs, and were more likely to have been widowed. At follow-up, Problem Drinkers (N = 192) differed from High-Risk Drinkers (N = 93) who denied multiple alcohol problems by exhibiting baseline lower LRs, higher Sensation Seeking, and a higher proportion who were widowed. Abstinent (N = 278) outcomes were predicted by a history of higher baseline AUD treatments, higher alcohol problems, lower usual drinks, as well as older age and European American heritage. Thirty-four subjects (4.9%) could not be classified and were not included in these analyses. Conclusions: These results generated from AUD individuals from both treatment and nontreatment settings reinforce low probabilities of recent Low-Risk Drinking in individuals with AUDs, but also suggest many individuals with AUDs demonstrate good outcomes 2 decades later.

LanguageEnglish (US)
JournalAlcoholism: Clinical and Experimental Research
DOIs
StateAccepted/In press - Jan 1 2018

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Alcoholism
Alcohols
Genetics
Drinking
Street Drugs
Analysis of variance (ANOVA)
Logistics
Analysis of Variance
Therapeutics
Logistic Models

Keywords

  • Alcohol
  • Geriatrics
  • Longitudinal
  • Prediction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism. / Schuckit, Marc A.; Smith, Tom L.; Danko, George; Kramer, John; Bucholz, Kathleen K.; Mccutcheon, Vivia; Chan, Grace; Kuperman, Samuel; Hesselbrock, Victor; Dick, Danielle M.; Hesselbrock, Michie; Porjesz, Bernice; Edenberg, Howard; Nureberger, John I.; Gregg, Marcy; Schoen, Lara; Kawamura, Mari; Mendoza, Lee Anne.

In: Alcoholism: Clinical and Experimental Research, 01.01.2018.

Research output: Contribution to journalArticle

Schuckit, MA, Smith, TL, Danko, G, Kramer, J, Bucholz, KK, Mccutcheon, V, Chan, G, Kuperman, S, Hesselbrock, V, Dick, DM, Hesselbrock, M, Porjesz, B, Edenberg, H, Nureberger, JI, Gregg, M, Schoen, L, Kawamura, M & Mendoza, LA 2018, 'A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism' Alcoholism: Clinical and Experimental Research. https://doi.org/10.1111/acer.13810
Schuckit, Marc A. ; Smith, Tom L. ; Danko, George ; Kramer, John ; Bucholz, Kathleen K. ; Mccutcheon, Vivia ; Chan, Grace ; Kuperman, Samuel ; Hesselbrock, Victor ; Dick, Danielle M. ; Hesselbrock, Michie ; Porjesz, Bernice ; Edenberg, Howard ; Nureberger, John I. ; Gregg, Marcy ; Schoen, Lara ; Kawamura, Mari ; Mendoza, Lee Anne. / A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism. In: Alcoholism: Clinical and Experimental Research. 2018.
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abstract = "Background: Recent reports indicate higher-than-expected problematic drinking in older populations. However, few data describe how to predict which older individuals are most likely to demonstrate alcohol-related problems, including those with earlier alcohol use disorders (AUDs). These analyses evaluate predictors of alcohol outcomes in individuals with earlier AUDs in the Collaborative Study on Genetics of Alcoholism (COGA). Methods: Original COGA participants with baseline AUDs at about age 40 were interviewed 13 to 26 years later and placed into clinically derived outcome categories. Chi-square and analysis of variance evaluated baseline differences across 4 outcome groups, with significant items entered into binary logistic regression backwards elimination analyses predicting outcomes. Results: Low-Risk Drinkers (N = 100) at follow-up were predicted by baseline higher levels of response to alcohol (high LRs), lower histories of alcohol treatment, experience with fewer types of illicit drugs, and were more likely to have been widowed. At follow-up, Problem Drinkers (N = 192) differed from High-Risk Drinkers (N = 93) who denied multiple alcohol problems by exhibiting baseline lower LRs, higher Sensation Seeking, and a higher proportion who were widowed. Abstinent (N = 278) outcomes were predicted by a history of higher baseline AUD treatments, higher alcohol problems, lower usual drinks, as well as older age and European American heritage. Thirty-four subjects (4.9{\%}) could not be classified and were not included in these analyses. Conclusions: These results generated from AUD individuals from both treatment and nontreatment settings reinforce low probabilities of recent Low-Risk Drinking in individuals with AUDs, but also suggest many individuals with AUDs demonstrate good outcomes 2 decades later.",
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AU - Smith, Tom L.

AU - Danko, George

AU - Kramer, John

AU - Bucholz, Kathleen K.

AU - Mccutcheon, Vivia

AU - Chan, Grace

AU - Kuperman, Samuel

AU - Hesselbrock, Victor

AU - Dick, Danielle M.

AU - Hesselbrock, Michie

AU - Porjesz, Bernice

AU - Edenberg, Howard

AU - Nureberger, John I.

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AU - Schoen, Lara

AU - Kawamura, Mari

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N2 - Background: Recent reports indicate higher-than-expected problematic drinking in older populations. However, few data describe how to predict which older individuals are most likely to demonstrate alcohol-related problems, including those with earlier alcohol use disorders (AUDs). These analyses evaluate predictors of alcohol outcomes in individuals with earlier AUDs in the Collaborative Study on Genetics of Alcoholism (COGA). Methods: Original COGA participants with baseline AUDs at about age 40 were interviewed 13 to 26 years later and placed into clinically derived outcome categories. Chi-square and analysis of variance evaluated baseline differences across 4 outcome groups, with significant items entered into binary logistic regression backwards elimination analyses predicting outcomes. Results: Low-Risk Drinkers (N = 100) at follow-up were predicted by baseline higher levels of response to alcohol (high LRs), lower histories of alcohol treatment, experience with fewer types of illicit drugs, and were more likely to have been widowed. At follow-up, Problem Drinkers (N = 192) differed from High-Risk Drinkers (N = 93) who denied multiple alcohol problems by exhibiting baseline lower LRs, higher Sensation Seeking, and a higher proportion who were widowed. Abstinent (N = 278) outcomes were predicted by a history of higher baseline AUD treatments, higher alcohol problems, lower usual drinks, as well as older age and European American heritage. Thirty-four subjects (4.9%) could not be classified and were not included in these analyses. Conclusions: These results generated from AUD individuals from both treatment and nontreatment settings reinforce low probabilities of recent Low-Risk Drinking in individuals with AUDs, but also suggest many individuals with AUDs demonstrate good outcomes 2 decades later.

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