A 2D crossover–based map of the human X chromosome as a model for map integration

Pamela R. Fain, Edward N. Kort, Phillip F. Chance, Kim Nguyen, Douglas F. Redd, Michael J. Econs, David F. Barker

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Abstract

We have contructed a two–dimensional map of 243 markers on the X chromosome. The average distance between markers ordered by two recombinants is 5.4 centiMorgans(cM), which is reduced to 3.2 cM using a less stringent criterion of one recombinant. Map resolution is enhanced by replacing the usual reference marker format with a 2D format, and the two–recombinant rule is more conservative than the lod 3.0 criterion for order. Taken together, crossover mapping and the 2D format produces maps with greater reliability and higher resolution than maps constructed using currently accepted standards. This first high–density crossover–based map of an entire human chromosome provides a model for integrating physical and genetic maps.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalNature genetics
Volume9
Issue number3
DOIs
StatePublished - Mar 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Fain, P. R., Kort, E. N., Chance, P. F., Nguyen, K., Redd, D. F., Econs, M. J., & Barker, D. F. (1995). A 2D crossover–based map of the human X chromosome as a model for map integration. Nature genetics, 9(3), 261-266. https://doi.org/10.1038/ng0395-261