A Biomarker Characterizing Neurodevelopment with applications in Autism

Di Wu, Jorge V. José, John Nurnberger, Elizabeth B. Torres

Research output: Contribution to journalArticle

  • 4 Citations

Abstract

Despite great advances in neuroscience and genetic studies, our understanding of neurodevelopmental disorders is still quite limited. An important reason is not having objective psychiatric clinical tests. Here we propose a quantitative neurodevelopment assessment by studying natural movement outputs. Movement is central to behaviors: It involves complex coordination, temporal alterations, and precise dynamic controls. We carefully analyzed the continuous movement output data, collected with high definition electromagnetic sensors at millisecond time scales. We unraveled new metrics containing striking physiological information that was unseen neither by using traditional motion assessments nor by naked eye observations. Our putative biomarker leads to precise individualized classifications. It illustrates clear differences between Autism Spectrum Disorder (ASD) subjects from mature typical developing (TD) individuals. It provides an ASD complementary quantitative classification, which closely agrees with the clinicaly assessed functioning levels in the spectrum. It also illustrates TD potential age-related neurodevelopmental trajectories. Applying our movement biomarker to the parents of the ASD individuals studied in the cohort also shows a novel potential familial signature ASD tie. This paper proposes a putative behavioral biomarker to characterize the level of neurodevelopment with high predicting power, as illustrated in ASD subjects as an example.

LanguageEnglish (US)
Article number614
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Autistic Disorder
Biomarkers
Electromagnetic Phenomena
Coordination Complexes
Neurosciences
Psychiatry
Autism Spectrum Disorder

ASJC Scopus subject areas

  • General

Cite this

A Biomarker Characterizing Neurodevelopment with applications in Autism. / Wu, Di; José, Jorge V.; Nurnberger, John; Torres, Elizabeth B.

In: Scientific Reports, Vol. 8, No. 1, 614, 01.12.2018.

Research output: Contribution to journalArticle

Wu, Di ; José, Jorge V. ; Nurnberger, John ; Torres, Elizabeth B. / A Biomarker Characterizing Neurodevelopment with applications in Autism. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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