A bipolar pedigree series for genomic mapping of disease genes: Diagnostic and analytic considerations

Wade H. Berrettini, Lynn R. Goldin, Maria M. Martinez, M. Elizabeth Maxwell, Anne L. Smith, Juliet J. Guroff, Diane M. Kazuba, John I. Nurnberger, Joel Hamovit, Susan Simmons-Alling, David Muniec, Henry Choi, Carolyn York, Adelaide S. Robb, Elliot S. Gershon

Research output: Contribution to journalArticle

28 Scopus citations


Twenty-one multiplex bipolar (BP) families, suitable for linkage studies, are described. The families include 365 informative persons (whose genotypes can be determined from available DNA samples), 154 of whom have BP, schizoaffective or recurrent unipolar diagnoses. The power of such a series to detect linkage is estimated through simulations under assumptions concerning the inheritance of BP illness, the genetic distances between the illness locus and markers, and marker heterozygosity. It is concluded that this series has greater than 50% power to detect linkage when only 25% of the families are linked to the locus under study. This paper is intended to serve as an introduction to a systematic genomic search for genes causing vulnerability to BP disease among these families.

Original languageEnglish (US)
Pages (from-to)125-160
Number of pages36
JournalPsychiatric genetics
Issue number2
StatePublished - Jan 1 1991


ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Berrettini, W. H., Goldin, L. R., Martinez, M. M., Maxwell, M. E., Smith, A. L., Guroff, J. J., Kazuba, D. M., Nurnberger, J. I., Hamovit, J., Simmons-Alling, S., Muniec, D., Choi, H., York, C., Robb, A. S., & Gershon, E. S. (1991). A bipolar pedigree series for genomic mapping of disease genes: Diagnostic and analytic considerations. Psychiatric genetics, 2(2), 125-160. https://doi.org/10.1097/00041444-199124000-00002