A brief history of IL-9

Ritobrata Goswami, Mark H. Kaplan

Research output: Contribution to journalShort survey

224 Scopus citations

Abstract

IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A resurgence of interest in IL-9 has been spurred by recent work demonstrating a role for IL-9 in regulating inflammatory immunity and defining the transcription factors that activate the Il9 gene in cells that most efficiently produce IL-9. In this review, we summarize the characterization of IL-9 biological activities, highlight roles for the cytokine that are clearly defined, and outline questions regarding IL-9 functions that still require further exploration.

Original languageEnglish (US)
Pages (from-to)3283-3288
Number of pages6
JournalJournal of Immunology
Volume186
Issue number6
DOIs
StatePublished - Mar 15 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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