A C. elegans Ror receptor tyresine kinase regulates cell motility and asymmetric cell division

Wayne C. Forrester, Megan Dell, Elliot Perens, Gian Garriga

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

Ror kinases are a family of orphan receptors with tyrosine kinase activity that are related to muscle specific kinase (MuSK), a receptor tyrosine kinase that assembles acetylcholine receptors at the neuromuscular junction. Although the functions of Ror kinases are unknown, similarities between Ror and MuSK kinases have led to speculation that Ror kinases regulate synaptic development. Here we show that the Caenorhabditis elegans gene cam1 encodes a member of the Ror kinase family that guides migrating cells and orients the polarity of asymmetric cell divisions and axon outgrowth. We find that tyrosine kinase activity is required for some of the functions of CAM-1, but not for its role in cell migration. CAM-1 is expressed in cells that require its function, and acts cell autonomously in migrating neurons. Overexpression and loss of cam-1 function result in reciprocal cell-migration phenotypes, indicating that levels of CAM-1 influence the final positions of migrating cells. Our results raise the possibility that Ror kinases regulate cell motility and asymmetric cell division in organisms as diverse as nematodes and mammals.

Original languageEnglish (US)
Pages (from-to)881-885
Number of pages5
JournalNature
Volume400
Issue number6747
DOIs
StatePublished - Aug 26 1999

ASJC Scopus subject areas

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