A case study: Refractory recurrent autoimmune hepatitis following liver transplantation in two male patients

V. Tencate, R. Komorowski, D. Cronin, J. Hong, S. Gawrieh

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Autoimmune hepatitis (AIH) recurs after liver transplantation and significantly impacts graft function and patient survival. In this case report, we present 2 cases of male patients with refractory recurrent AIH after liver transplantation. Each patient lost their first graft due to refractory continuous AIH. We have not noticed a similar refractory course for our female patients with AIH post-transplantation at our center. Based on our single-center experience there appears to be a gender disparity in the aggressive nature of AIH recurrence after transplantation. Despite the aggressive nature of recurrent AIH in both patients, graft loss occurred beyond 3 years for both patients and did not influence the 1- and 3-year patient survival. If these findings are validated, they may have significant impact on post-transplantation immunosuppression management in male patients.

Original languageEnglish (US)
Pages (from-to)298-300
Number of pages3
JournalTransplantation proceedings
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

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