A cellular trojan horse for delivery of therapeutic nanoparticles into tumors

Mi Ran Choi, Katie J. Stanton-Maxey, Jennifer K. Stanley, Carly S. Levin, Rizia Bardhan, Demir Akin, Sunil Badve, Jennifer Sturgis, J. Paul Robinson, Rashid Bashir, Naomi J. Halas, Susan E. Clare

Research output: Contribution to journalArticle

375 Citations (Scopus)

Abstract

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

Original languageEnglish (US)
Pages (from-to)3759-3765
Number of pages7
JournalNano Letters
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2007

Fingerprint

monocytes
Tumors
delivery
tumors
Nanoparticles
nanoparticles
Nanoshells
macrophages
Macrophages
spheroids
Cell death
death
progressions
destruction
therapy
Demonstrations
cancer

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Choi, M. R., Stanton-Maxey, K. J., Stanley, J. K., Levin, C. S., Bardhan, R., Akin, D., ... Clare, S. E. (2007). A cellular trojan horse for delivery of therapeutic nanoparticles into tumors. Nano Letters, 7(12), 3759-3765. https://doi.org/10.1021/nl072209h

A cellular trojan horse for delivery of therapeutic nanoparticles into tumors. / Choi, Mi Ran; Stanton-Maxey, Katie J.; Stanley, Jennifer K.; Levin, Carly S.; Bardhan, Rizia; Akin, Demir; Badve, Sunil; Sturgis, Jennifer; Robinson, J. Paul; Bashir, Rashid; Halas, Naomi J.; Clare, Susan E.

In: Nano Letters, Vol. 7, No. 12, 01.12.2007, p. 3759-3765.

Research output: Contribution to journalArticle

Choi, MR, Stanton-Maxey, KJ, Stanley, JK, Levin, CS, Bardhan, R, Akin, D, Badve, S, Sturgis, J, Robinson, JP, Bashir, R, Halas, NJ & Clare, SE 2007, 'A cellular trojan horse for delivery of therapeutic nanoparticles into tumors', Nano Letters, vol. 7, no. 12, pp. 3759-3765. https://doi.org/10.1021/nl072209h
Choi, Mi Ran ; Stanton-Maxey, Katie J. ; Stanley, Jennifer K. ; Levin, Carly S. ; Bardhan, Rizia ; Akin, Demir ; Badve, Sunil ; Sturgis, Jennifer ; Robinson, J. Paul ; Bashir, Rashid ; Halas, Naomi J. ; Clare, Susan E. / A cellular trojan horse for delivery of therapeutic nanoparticles into tumors. In: Nano Letters. 2007 ; Vol. 7, No. 12. pp. 3759-3765.
@article{2f220eacdae14a12a556a0708eec1ee2,
title = "A cellular trojan horse for delivery of therapeutic nanoparticles into tumors",
abstract = "Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as {"}Trojan Horses{"} for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.",
author = "Choi, {Mi Ran} and Stanton-Maxey, {Katie J.} and Stanley, {Jennifer K.} and Levin, {Carly S.} and Rizia Bardhan and Demir Akin and Sunil Badve and Jennifer Sturgis and Robinson, {J. Paul} and Rashid Bashir and Halas, {Naomi J.} and Clare, {Susan E.}",
year = "2007",
month = "12",
day = "1",
doi = "10.1021/nl072209h",
language = "English (US)",
volume = "7",
pages = "3759--3765",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - A cellular trojan horse for delivery of therapeutic nanoparticles into tumors

AU - Choi, Mi Ran

AU - Stanton-Maxey, Katie J.

AU - Stanley, Jennifer K.

AU - Levin, Carly S.

AU - Bardhan, Rizia

AU - Akin, Demir

AU - Badve, Sunil

AU - Sturgis, Jennifer

AU - Robinson, J. Paul

AU - Bashir, Rashid

AU - Halas, Naomi J.

AU - Clare, Susan E.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

AB - Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

UR - http://www.scopus.com/inward/record.url?scp=38049131877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049131877&partnerID=8YFLogxK

U2 - 10.1021/nl072209h

DO - 10.1021/nl072209h

M3 - Article

C2 - 17979310

AN - SCOPUS:38049131877

VL - 7

SP - 3759

EP - 3765

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 12

ER -