A cholinergic receptor gene (CHRM2) affects event-related oscillations

Kevin A. Jones, Bernice Porjesz, Laura Almasy, Laura Bierut, Danielle Dick, Alison Goate, Anthony Hinrichs, John P. Rice, Jen C. Wang, Lance O. Bauer, Raymond Crowe, Tatiana Foroud, Victor Hesselbrock, Samuel Kuperman, John Nurnberger, Sean O'Connor, John Rohrbaugh, Marc A. Schuckit, Jay Tischfield, Howard EdenbergHenri Begleiter

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We report genetic linkage and association findings which implicate the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) in the modulation of a scalp-recorded electrophysiological phenotype. The P3 (P300) response was evoked using a three-stimulus visual oddball paradigm and a phenotype that relates to the energy in the theta band (4-5 Hz) was analyzed. Studies have shown that similar electrophysiological measures represent cognitive correlates of attention, working memory, and response selection; a role has been suggested for the ascending cholinergic pathway in the same functions. The results of our genetic association tests, combined with knowledge regarding the presence of presynaptic cholinergic M2 autoreceptors in the basal forebrain, indicate that the cognitive processes required by the experiment may in part be mediated by inhibitory neural networks. These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders.

Original languageEnglish
Pages (from-to)627-639
Number of pages13
JournalBehavior Genetics
Volume36
Issue number5
DOIs
StatePublished - Sep 2006

Fingerprint

cholinergic receptors
cholinergic agents
Cholinergic Receptors
cognition
Cholinergic Agents
oscillation
phenotype
Muscarinic M2 Receptors
Phenotype
brain
Autoreceptors
electrophysiology
Genetic Linkage
selection response
visual cue
gene
Electrophysiology
Brain Diseases
Muscarinic Receptors
Scalp

Keywords

  • Acetylcholine
  • Cholinergic
  • EEG
  • Event-related
  • Inhibition
  • Oscillation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Jones, K. A., Porjesz, B., Almasy, L., Bierut, L., Dick, D., Goate, A., ... Begleiter, H. (2006). A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behavior Genetics, 36(5), 627-639. https://doi.org/10.1007/s10519-006-9075-6

A cholinergic receptor gene (CHRM2) affects event-related oscillations. / Jones, Kevin A.; Porjesz, Bernice; Almasy, Laura; Bierut, Laura; Dick, Danielle; Goate, Alison; Hinrichs, Anthony; Rice, John P.; Wang, Jen C.; Bauer, Lance O.; Crowe, Raymond; Foroud, Tatiana; Hesselbrock, Victor; Kuperman, Samuel; Nurnberger, John; O'Connor, Sean; Rohrbaugh, John; Schuckit, Marc A.; Tischfield, Jay; Edenberg, Howard; Begleiter, Henri.

In: Behavior Genetics, Vol. 36, No. 5, 09.2006, p. 627-639.

Research output: Contribution to journalArticle

Jones, KA, Porjesz, B, Almasy, L, Bierut, L, Dick, D, Goate, A, Hinrichs, A, Rice, JP, Wang, JC, Bauer, LO, Crowe, R, Foroud, T, Hesselbrock, V, Kuperman, S, Nurnberger, J, O'Connor, S, Rohrbaugh, J, Schuckit, MA, Tischfield, J, Edenberg, H & Begleiter, H 2006, 'A cholinergic receptor gene (CHRM2) affects event-related oscillations', Behavior Genetics, vol. 36, no. 5, pp. 627-639. https://doi.org/10.1007/s10519-006-9075-6
Jones KA, Porjesz B, Almasy L, Bierut L, Dick D, Goate A et al. A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behavior Genetics. 2006 Sep;36(5):627-639. https://doi.org/10.1007/s10519-006-9075-6
Jones, Kevin A. ; Porjesz, Bernice ; Almasy, Laura ; Bierut, Laura ; Dick, Danielle ; Goate, Alison ; Hinrichs, Anthony ; Rice, John P. ; Wang, Jen C. ; Bauer, Lance O. ; Crowe, Raymond ; Foroud, Tatiana ; Hesselbrock, Victor ; Kuperman, Samuel ; Nurnberger, John ; O'Connor, Sean ; Rohrbaugh, John ; Schuckit, Marc A. ; Tischfield, Jay ; Edenberg, Howard ; Begleiter, Henri. / A cholinergic receptor gene (CHRM2) affects event-related oscillations. In: Behavior Genetics. 2006 ; Vol. 36, No. 5. pp. 627-639.
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