A chromosomal region 7p11.2 transcript map

Its development and application to the study of EGFR amplicons in glioblastoma

Greg D. Eley, Jill Reiter, Ajay Pandita, Soyeon Park, Robert B. Jenkins, Nita J. Maihle, C. David James

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Cumulative information available about the organization of amplified chromosomal regions in human tumors suggests that the amplification repeat units, or amplicons, can be of a simple or complex nature. For the former, amplified regions generally retain their native chromosomal configuration and involve a single amplification target sequence. For complex amplicons, amplified DNAs usually undergo substantial reorganization relative to the normal chromosomal regions from which they evolve, and the regions subject to amplification may contain multiple target sequences. Previous efforts to characterize the 7p11.2 epidermal growth factor receptor (EGFR) amplicon in glioblastoma have relied primarily on the use of markers positioned by linkage analysis and/or radiation hybrid mapping, both of which are known to have the potential for being inaccurate when attempting to order loci over relatively short (

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalNeuro-Oncology
Volume4
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

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Radiation Hybrid Mapping
Glioblastoma
Epidermal Growth Factor Receptor
DNA
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

A chromosomal region 7p11.2 transcript map : Its development and application to the study of EGFR amplicons in glioblastoma. / Eley, Greg D.; Reiter, Jill; Pandita, Ajay; Park, Soyeon; Jenkins, Robert B.; Maihle, Nita J.; James, C. David.

In: Neuro-Oncology, Vol. 4, No. 2, 2002, p. 86-94.

Research output: Contribution to journalArticle

Eley, Greg D. ; Reiter, Jill ; Pandita, Ajay ; Park, Soyeon ; Jenkins, Robert B. ; Maihle, Nita J. ; James, C. David. / A chromosomal region 7p11.2 transcript map : Its development and application to the study of EGFR amplicons in glioblastoma. In: Neuro-Oncology. 2002 ; Vol. 4, No. 2. pp. 86-94.
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