A chronic outcome of shock wave lithotripsy is parenchymal fibrosis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Shock wave lithotripsy (SWL) is widely viewed as an effective noninvasive method to break stones within the kidney and ureter. However, it is a technology that is not without trauma to the kidney-acute vascular, tubular and interstitial damage is often reported that if severe enough can lead to renal fibrosis (scarring) and permanent loss of functional parenchyma. These chronic changes can potentially lead to serious long-term adverse effects. The risk of developing chronic fibrotic lesions after lithotripsy is influenced by the number of shock waves (SWs) administered, SW power, rate of SW delivery and the number of SWL treatment sessions. The interplay between these risk factors is largely unknown, but progress has been made in identifying SWL protocols and pharmacologic therapies that can ameliorate the acute and chronic tissue damage that is an unintended consequence of SWL treatment.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalUrological Research
Volume38
Issue number4
DOIs
StatePublished - Aug 2010

Fingerprint

Lithotripsy
Fibrosis
Kidney
Kidney Calculi
Ureter
Cicatrix
Blood Vessels
Therapeutics
Technology
Wounds and Injuries

Keywords

  • Fibrosis
  • Kidney
  • Shock wave lithotripsy

ASJC Scopus subject areas

  • Urology

Cite this

A chronic outcome of shock wave lithotripsy is parenchymal fibrosis. / Handa, Rajash; Evan, Andrew.

In: Urological Research, Vol. 38, No. 4, 08.2010, p. 301-305.

Research output: Contribution to journalArticle

@article{6e920a96021e4766a3552c04c1281c9c,
title = "A chronic outcome of shock wave lithotripsy is parenchymal fibrosis",
abstract = "Shock wave lithotripsy (SWL) is widely viewed as an effective noninvasive method to break stones within the kidney and ureter. However, it is a technology that is not without trauma to the kidney-acute vascular, tubular and interstitial damage is often reported that if severe enough can lead to renal fibrosis (scarring) and permanent loss of functional parenchyma. These chronic changes can potentially lead to serious long-term adverse effects. The risk of developing chronic fibrotic lesions after lithotripsy is influenced by the number of shock waves (SWs) administered, SW power, rate of SW delivery and the number of SWL treatment sessions. The interplay between these risk factors is largely unknown, but progress has been made in identifying SWL protocols and pharmacologic therapies that can ameliorate the acute and chronic tissue damage that is an unintended consequence of SWL treatment.",
keywords = "Fibrosis, Kidney, Shock wave lithotripsy",
author = "Rajash Handa and Andrew Evan",
year = "2010",
month = "8",
doi = "10.1007/s00240-010-0297-y",
language = "English",
volume = "38",
pages = "301--305",
journal = "Urolithiasis",
issn = "2194-7228",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - A chronic outcome of shock wave lithotripsy is parenchymal fibrosis

AU - Handa, Rajash

AU - Evan, Andrew

PY - 2010/8

Y1 - 2010/8

N2 - Shock wave lithotripsy (SWL) is widely viewed as an effective noninvasive method to break stones within the kidney and ureter. However, it is a technology that is not without trauma to the kidney-acute vascular, tubular and interstitial damage is often reported that if severe enough can lead to renal fibrosis (scarring) and permanent loss of functional parenchyma. These chronic changes can potentially lead to serious long-term adverse effects. The risk of developing chronic fibrotic lesions after lithotripsy is influenced by the number of shock waves (SWs) administered, SW power, rate of SW delivery and the number of SWL treatment sessions. The interplay between these risk factors is largely unknown, but progress has been made in identifying SWL protocols and pharmacologic therapies that can ameliorate the acute and chronic tissue damage that is an unintended consequence of SWL treatment.

AB - Shock wave lithotripsy (SWL) is widely viewed as an effective noninvasive method to break stones within the kidney and ureter. However, it is a technology that is not without trauma to the kidney-acute vascular, tubular and interstitial damage is often reported that if severe enough can lead to renal fibrosis (scarring) and permanent loss of functional parenchyma. These chronic changes can potentially lead to serious long-term adverse effects. The risk of developing chronic fibrotic lesions after lithotripsy is influenced by the number of shock waves (SWs) administered, SW power, rate of SW delivery and the number of SWL treatment sessions. The interplay between these risk factors is largely unknown, but progress has been made in identifying SWL protocols and pharmacologic therapies that can ameliorate the acute and chronic tissue damage that is an unintended consequence of SWL treatment.

KW - Fibrosis

KW - Kidney

KW - Shock wave lithotripsy

UR - http://www.scopus.com/inward/record.url?scp=77956188316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956188316&partnerID=8YFLogxK

U2 - 10.1007/s00240-010-0297-y

DO - 10.1007/s00240-010-0297-y

M3 - Article

VL - 38

SP - 301

EP - 305

JO - Urolithiasis

JF - Urolithiasis

SN - 2194-7228

IS - 4

ER -