A clinical index to stratify hospitalized older adults according to risk for new-onset disability

Kala M. Mehta, Edgar Pierluissi, W. John Boscardin, Katharine A. Kirby, Louise C. Walter, Mary Margaret Chren, Robert M. Palmer, Steven Counsell, C. Seth Landefeld

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

BACKGROUND: Many older adults who are independent prior to hospitalization develop a new disability by hospital discharge. Early risk stratification for new-onset disability may improve care. Thus, this study's objective was to develop and validate a clinical index to determine, at admission, risk for new-onset disability among older, hospitalized adults at discharge. DESIGN: Data analyses derived from two prospective studies. SETTING: Two teaching hospitals in Ohio. PARTICIPANTS: Eight hundred eighty-five patients aged 70 years and older were discharged from a general medical service at a tertiary care hospital (mean age 78, 59% female) and 753 patients discharged from a separate community teaching hospital (mean age 79, 63% female). All participants reported being independent in five activities of daily living (ADLs: bathing, dressing, transferring, toileting, and eating) 2 weeks before admission. MEASUREMENTS: New-onset disability, defined as a new need for personal assistance in one or more ADLs at discharge in participants who were independent 2 weeks before hospital admission. RESULTS: Seven independent risk factors known on admission were identified and weighted using logistic regression: age (80-89, 1 point; ≥90, 2 points); dependence in three or more instrumental ADLs at baseline (2 points); impaired mobility at baseline (unable to run, 1 point; unable to climb stairs, 2 points); dependence in ADLs at admission (2-3 ADLs, 1 point; 4-5 ADLs, 3 points); acute stroke or metastatic cancer (2 points); severe cognitive impairment (1 point); and albumin less than 3.0 g/dL (2 points). New-onset disability occurred in 6%, 13%, 18%, 34%, 35%, 45%, 50%, and 87% of participants with 0, 1, 2, 3, 4, 5, 6, and 7 or more points, respectively, in the derivation cohort (area under the receiver operating characteristic curve (AUC)=0.784), and in 8%, 10%, 27%, 38%, 44%, 45%, 58%, and 83%, respectively, in the validation cohort (AUC=0.784). The risk score also predicted (P<.001) disability severity, nursing home placement, and long-term survival. CONCLUSION: This clinical index determines risk for new-onset disability in hospitalized older adults and may inform clinical care.

Original languageEnglish
Pages (from-to)1206-1216
Number of pages11
JournalJournal of the American Geriatrics Society
Volume59
Issue number7
DOIs
StatePublished - Jul 2011

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Activities of Daily Living
Teaching Hospitals
Area Under Curve
Community Hospital
Tertiary Healthcare
Bandages
Nursing Homes
Tertiary Care Centers
ROC Curve
Albumins
Hospitalization
Logistic Models
Stroke
Prospective Studies
Neoplasms

Keywords

  • activities of daily living
  • disability
  • hospitalization
  • prognosis

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Mehta, K. M., Pierluissi, E., Boscardin, W. J., Kirby, K. A., Walter, L. C., Chren, M. M., ... Landefeld, C. S. (2011). A clinical index to stratify hospitalized older adults according to risk for new-onset disability. Journal of the American Geriatrics Society, 59(7), 1206-1216. https://doi.org/10.1111/j.1532-5415.2011.03409.x

A clinical index to stratify hospitalized older adults according to risk for new-onset disability. / Mehta, Kala M.; Pierluissi, Edgar; Boscardin, W. John; Kirby, Katharine A.; Walter, Louise C.; Chren, Mary Margaret; Palmer, Robert M.; Counsell, Steven; Landefeld, C. Seth.

In: Journal of the American Geriatrics Society, Vol. 59, No. 7, 07.2011, p. 1206-1216.

Research output: Contribution to journalArticle

Mehta, KM, Pierluissi, E, Boscardin, WJ, Kirby, KA, Walter, LC, Chren, MM, Palmer, RM, Counsell, S & Landefeld, CS 2011, 'A clinical index to stratify hospitalized older adults according to risk for new-onset disability', Journal of the American Geriatrics Society, vol. 59, no. 7, pp. 1206-1216. https://doi.org/10.1111/j.1532-5415.2011.03409.x
Mehta, Kala M. ; Pierluissi, Edgar ; Boscardin, W. John ; Kirby, Katharine A. ; Walter, Louise C. ; Chren, Mary Margaret ; Palmer, Robert M. ; Counsell, Steven ; Landefeld, C. Seth. / A clinical index to stratify hospitalized older adults according to risk for new-onset disability. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 7. pp. 1206-1216.
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N2 - BACKGROUND: Many older adults who are independent prior to hospitalization develop a new disability by hospital discharge. Early risk stratification for new-onset disability may improve care. Thus, this study's objective was to develop and validate a clinical index to determine, at admission, risk for new-onset disability among older, hospitalized adults at discharge. DESIGN: Data analyses derived from two prospective studies. SETTING: Two teaching hospitals in Ohio. PARTICIPANTS: Eight hundred eighty-five patients aged 70 years and older were discharged from a general medical service at a tertiary care hospital (mean age 78, 59% female) and 753 patients discharged from a separate community teaching hospital (mean age 79, 63% female). All participants reported being independent in five activities of daily living (ADLs: bathing, dressing, transferring, toileting, and eating) 2 weeks before admission. MEASUREMENTS: New-onset disability, defined as a new need for personal assistance in one or more ADLs at discharge in participants who were independent 2 weeks before hospital admission. RESULTS: Seven independent risk factors known on admission were identified and weighted using logistic regression: age (80-89, 1 point; ≥90, 2 points); dependence in three or more instrumental ADLs at baseline (2 points); impaired mobility at baseline (unable to run, 1 point; unable to climb stairs, 2 points); dependence in ADLs at admission (2-3 ADLs, 1 point; 4-5 ADLs, 3 points); acute stroke or metastatic cancer (2 points); severe cognitive impairment (1 point); and albumin less than 3.0 g/dL (2 points). New-onset disability occurred in 6%, 13%, 18%, 34%, 35%, 45%, 50%, and 87% of participants with 0, 1, 2, 3, 4, 5, 6, and 7 or more points, respectively, in the derivation cohort (area under the receiver operating characteristic curve (AUC)=0.784), and in 8%, 10%, 27%, 38%, 44%, 45%, 58%, and 83%, respectively, in the validation cohort (AUC=0.784). The risk score also predicted (P<.001) disability severity, nursing home placement, and long-term survival. CONCLUSION: This clinical index determines risk for new-onset disability in hospitalized older adults and may inform clinical care.

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