A comparative analysis of viral matrix proteins using disorder predictors

Gerard Kian Meng Goh, A. Dunker, Vladimir N. Uversky

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background. A previous study (Goh G.K.-M., Dunker A.K., Uversky V.N. (2008) Protein intrinsic disorder toolbox for comparative analysis of viral proteins. BMC Genomics. 9 (Suppl. 2), S4) revealed that HIV matrix protein p17 possesses especially high levels of predicted intrinsic disorder (PID). In this study, we analyzed the PID patterns in matrix proteins of viruses related and unrelated to HIV-1. Results. Both SIVmac and HIV-1 p17 proteins were predicted by PONDR VLXT to be highly disordered with subtle differences containing 50% and 60% disordered residues, respectively. SIVmac is very closely related to HIV-2. A specific region that is predicted to be disordered in HIV-1 is missing in SIVmac. The distributions of PID patterns seem to differ in SIVmac and HIV-1 p17 proteins. A high level of PID for the matrix does not seem to be mandatory for retroviruses, since Equine Infectious Anemia Virus (EIAV), an HIV cousin, has been predicted to have low PID level for the matrix; i.e. its matrix protein p15 contains only 21% PID residues. Surprisingly, the PID percentage and the pattern of predicted disorder distribution for p15 resemble those of the influenza matrix protein M1 (25%). Conclusion. Our data might have important implications in the search for HIV vaccines since disorder in the matrix protein might provide a mechanism for immune evasion.

Original languageEnglish
Article number126
JournalVirology Journal
Volume5
DOIs
StatePublished - 2008

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Viral Matrix Proteins
HIV-1
Proteins
Equine infectious anemia virus
Human Immunodeficiency Virus Proteins
Immune Evasion
AIDS Vaccines
HIV-2
Viral Proteins
Retroviridae
Genomics
Human Influenza
HIV
Viruses

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

A comparative analysis of viral matrix proteins using disorder predictors. / Goh, Gerard Kian Meng; Dunker, A.; Uversky, Vladimir N.

In: Virology Journal, Vol. 5, 126, 2008.

Research output: Contribution to journalArticle

Goh, Gerard Kian Meng ; Dunker, A. ; Uversky, Vladimir N. / A comparative analysis of viral matrix proteins using disorder predictors. In: Virology Journal. 2008 ; Vol. 5.
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