A comparative evaluation of antimicrobial coated versus nonantimicrobial coated peripherally inserted central catheters on associated outcomes: A randomized controlled trial

Susan Storey, Jamie Brown, Angela Foley, Erica Newkirk, Jan Powers, Julie Barger, Karen Paige

Research output: Contribution to journalArticle

11 Scopus citations


Background Central line-associated bloodstream infections (CLABSIs) are a common life-threatening risk factor associated with central venous catheters (CVCs). Research has demonstrated benefit in reducing CLABSIs when CVCs coated with antimicrobials are inserted. The impact of chlorhexidine (CHG)-impregnated versus non-CHG peripherally inserted central catheters (PICCs) on risk of CLABSI is unknown. Venous thromboembolism (VTE) is also a complication associated with CVCs. This study compares the impact of both PICC lines on these outcomes. Methods Patients in 3 high-risk units were randomly assigned to receive either a CHG-impregnated or non-CHG PICC line. Laboratory data were collected and reviewed daily on all study patients. The PICC dressing site was assessed daily. Medical record documentation was reviewed to determine presence of CLABSI or VTE. Results There were 167 patients who completed the study. Three patients developed CLABSI (2 in the CHG group, and 1 in the non-CHG group), and 3 patients developed VTE (2 in the non-CHG group, and 1 in the CHG group). No significant relationship was noted between the type of PICC line on development of a CLABSI (P =.61) or VTE (P >.99). A significant difference was noted in moderate bleeding (P ≤.001) requiring thrombogenic dressing in the patients who had the CHG PICC line. Conclusions No differences were noted in the development of CLABSI and VTE between the CHG and non-CHG groups.

Original languageEnglish (US)
Pages (from-to)636-641
Number of pages6
JournalAmerican Journal of Infection Control
Issue number6
StatePublished - Jun 1 2016



  • Catheter line-associated bloodstream infection
  • chlorhexidine-impregnated peripherally inserted central catheter lines
  • patient outcomes
  • peripherally inserted central catheters
  • randomized controlled trial
  • venous thromboembolism

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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