A comparative study to screen dementia and APOE genotypes in an ageing East African population

Chien Hsiun Chen, Toshiki Mizuno, Robert Elston, Monica M. Kariuki, Kathleen Hall, Frederick Unverzagt, Hugh Hendrie, Samuel Gatere, Paul Kioy, Nilesh B. Patel, Robert P. Friedland, Raj N. Kalaria

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E e{open}4 allele frequencies were high (∼30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.

Original languageEnglish
Pages (from-to)732-740
Number of pages9
JournalNeurobiology of Aging
Volume31
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Dementia
Genotype
Alzheimer Disease
Population
Interviews
Kenya
Apolipoproteins E
Nigeria
Gene Frequency
African Americans
Language
Education
Sensitivity and Specificity
Genes

Keywords

  • Africa
  • Alzheimer's disease
  • Apolipoprotein E
  • Cognitive impairment
  • Dementia
  • Kenya
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

A comparative study to screen dementia and APOE genotypes in an ageing East African population. / Chen, Chien Hsiun; Mizuno, Toshiki; Elston, Robert; Kariuki, Monica M.; Hall, Kathleen; Unverzagt, Frederick; Hendrie, Hugh; Gatere, Samuel; Kioy, Paul; Patel, Nilesh B.; Friedland, Robert P.; Kalaria, Raj N.

In: Neurobiology of Aging, Vol. 31, No. 5, 05.2010, p. 732-740.

Research output: Contribution to journalArticle

Chen, CH, Mizuno, T, Elston, R, Kariuki, MM, Hall, K, Unverzagt, F, Hendrie, H, Gatere, S, Kioy, P, Patel, NB, Friedland, RP & Kalaria, RN 2010, 'A comparative study to screen dementia and APOE genotypes in an ageing East African population', Neurobiology of Aging, vol. 31, no. 5, pp. 732-740. https://doi.org/10.1016/j.neurobiolaging.2008.06.014
Chen, Chien Hsiun ; Mizuno, Toshiki ; Elston, Robert ; Kariuki, Monica M. ; Hall, Kathleen ; Unverzagt, Frederick ; Hendrie, Hugh ; Gatere, Samuel ; Kioy, Paul ; Patel, Nilesh B. ; Friedland, Robert P. ; Kalaria, Raj N. / A comparative study to screen dementia and APOE genotypes in an ageing East African population. In: Neurobiology of Aging. 2010 ; Vol. 31, No. 5. pp. 732-740.
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