A comparison of cardiovascular disease risk factor biomarkers in African Americans and Yoruba Nigerians

M. Deeg, O. Baiyewu, Sujuan Gao, A. Ogunniyi, J. Shen, O. Gureje, S. Taylor, J. Murrell, Frederick Unverzagt, V. Smith-Gamble, R. Evans, J. Dickens, Hugh Hendrie, Kathleen Hall

Research output: Contribution to journalArticle

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Abstract

Objective: Classical risk factors for coronary artery disease are changing in the developing world while rates of cardiovascular disease are increasing in these populations. Newer risk factors have been identified for cardiovascular disease, but these have been rarely examined in elderly populations and not those of developing countries. Methods: This study was a cross-sectional comparison from a longitudinal, observational, epidemiologic study in which participants are interviewed at three-year intervals. The sample included 1510 African Americans from Indianapolis, Indiana, and 1254 Yoruba from Ibadan, Nigeria. We compared anthropomorphic measurements; biomarkers of endothelial dysfunction (plasminogen activator inhibitor type 1 [PAI-1] and E-selectin), inflammation (C-reactive protein), and lipid oxidation (8-isoprostane); and levels of lipids, homocysteine, folate, and vitamin B12. Results: Cholesterol, triglycerides, and low-density lipoprotein cholesterol levels were higher in African Americans. For markers of endothelial dysfunction, E-selectin and homocysteine differed between men, and PAI-1 was higher in the Yoruba. C-reactive protein differed only in women, but 8-isoprostane was higher in the Yoruba. Conclusion: Higher lipid levels in African Americans are consistent with their Western diet and lifestyle. Oxidative stress appears to be higher in the Yoruba than in African Americans, which may be secondary to dietary differences. Whether these differences in classical and emerging risk factors account for the different rates of cardiovascular disease, dementia, or other morbidities in these two populations remains to be determined.

Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalEthnicity and Disease
Volume18
Issue number4
StatePublished - Sep 2008

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8-epi-prostaglandin F2alpha
African Americans
Cardiovascular Diseases
Biomarkers
E-Selectin
Plasminogen Activator Inhibitor 1
Homocysteine
Lipids
C-Reactive Protein
Population
Plasminogen Inactivators
Vitamin B 12
Nigeria
Folic Acid
LDL Cholesterol
Developing Countries
Observational Studies
Dementia
Life Style
Epidemiologic Studies

Keywords

  • African Americans
  • Biomarkers
  • Cardiovascular risk
  • Nigerians

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

A comparison of cardiovascular disease risk factor biomarkers in African Americans and Yoruba Nigerians. / Deeg, M.; Baiyewu, O.; Gao, Sujuan; Ogunniyi, A.; Shen, J.; Gureje, O.; Taylor, S.; Murrell, J.; Unverzagt, Frederick; Smith-Gamble, V.; Evans, R.; Dickens, J.; Hendrie, Hugh; Hall, Kathleen.

In: Ethnicity and Disease, Vol. 18, No. 4, 09.2008, p. 427-433.

Research output: Contribution to journalArticle

Deeg, M, Baiyewu, O, Gao, S, Ogunniyi, A, Shen, J, Gureje, O, Taylor, S, Murrell, J, Unverzagt, F, Smith-Gamble, V, Evans, R, Dickens, J, Hendrie, H & Hall, K 2008, 'A comparison of cardiovascular disease risk factor biomarkers in African Americans and Yoruba Nigerians', Ethnicity and Disease, vol. 18, no. 4, pp. 427-433.
Deeg, M. ; Baiyewu, O. ; Gao, Sujuan ; Ogunniyi, A. ; Shen, J. ; Gureje, O. ; Taylor, S. ; Murrell, J. ; Unverzagt, Frederick ; Smith-Gamble, V. ; Evans, R. ; Dickens, J. ; Hendrie, Hugh ; Hall, Kathleen. / A comparison of cardiovascular disease risk factor biomarkers in African Americans and Yoruba Nigerians. In: Ethnicity and Disease. 2008 ; Vol. 18, No. 4. pp. 427-433.
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