A comparison of one year of episodic or suppressive treatment of recurrent genital herpes with valacyclovir

Kenneth H. Fife, Jennifer Almekinder, Susan Ofner

Research output: Contribution to journalArticle

17 Scopus citations


OBJECTIVES: We conducted this study to compare episodic and suppressive therapy for genital herpes about disease characteristics, disease burden, and psychologic impact. STUDY DESIGN: The authors conducted a randomized, open-label, 1-year treatment trial. RESULTS: Forty subjects were randomized to episodic therapy with valacyclovir (500 mg twice daily for 5 days) and 40 to suppressive therapy (500 mg daily). Subjects in the episodic arm experienced more outbreaks (7.87 ± 4.65) than those in the suppressive arm (1.59 ± 1.93) (P <0.001). Subjects in the episodic arm also had significantly more days with pain and lesions (6.5 ± 7.3) than those in the suppressive arm (1.1 ± 3.3) (P < 0.001), and other quantitative measures of disease burden also favored the suppressive arm. Both treatment groups had significant improvements in their recurrent genital herpes quality-of-life scores from baseline that persisted throughout the study; however, there was no significant difference between the treatment arms in these scores. CONCLUSIONS: Suppressive therapy of recurrent genital herpes with valacyclovir has a greater impact on measures of disease frequency and burden than episodic therapy. However, both treatment strategies lead to significant improvements in recurrent genital herpes quality-of-life scores. Both treatment strategies benefit patients with recurrent genital herpes.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalSexually transmitted diseases
Issue number5
StatePublished - May 1 2007


ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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