A comparison of the responses of cultured myoblasts and chrondrocytes to fibroblast and epidermal growth factors

D. Gospodarowicz, Anthony Mescher

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The effects of fibroblast and epidermal growth factors on proliferation and differentiation of cultured myoblasts and chondrocytes were compared. FGF stimulated myoblast proliferation, as determined by monitoring levels of DNA synthesis during 7 days growth in vitro and by the morphology of the cultures after myotube formation. EGF has relatively little effect on myoblast proliferation. With chondrocytes, both FGF and EGF are mitogenic and FGF's, but not EGF's effect is potentiated by dexamethasone. One implication of these results is that in the course of differentiation cell types which develop from the same embryonic origin as fibroblasts are controlled by different sets of mitogenic factors. Myoblasts become primarily dependent on mitogenic agents such as FGF while chondrocytes can respond to both FGF and EGF.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalJournal of Cellular Physiology
Volume93
Issue number1
StatePublished - 1977
Externally publishedYes

Fingerprint

Myoblasts
Fibroblasts
Epidermal Growth Factor
Chondrocytes
Skeletal Muscle Fibers
Dexamethasone
Cell Differentiation
EGF Family of Proteins
Monitoring
DNA
Growth

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

A comparison of the responses of cultured myoblasts and chrondrocytes to fibroblast and epidermal growth factors. / Gospodarowicz, D.; Mescher, Anthony.

In: Journal of Cellular Physiology, Vol. 93, No. 1, 1977, p. 117-127.

Research output: Contribution to journalArticle

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