A comprehensive evaluation of outcomes for inflammatory breast cancer

Relin Yang, Michael C. Cheung, Judith Hurley, Margaret M. Byrne, Youjie Huang, Teresa Zimmers, Leonidas Koniaris

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective Inflammatory breast cancer (IBC) remains the breast malignancy with the worst prognosis. We sought to determine the effects of race, socioeconomic status and treatment on outcomes for women with IBC. Study design The Florida cancer registry, inpatient and ambulatory data were queried for patients diagnosed from 1998 to 2002. Results A total of 935 patients with IBC were identified (1.5% of all breast cancers). Overall, 83.1% were Caucasian, 13.9% African American (AA), and 15.7% Hispanic. The mean age of diagnosis was 57 years old. AA patients presented at a younger age, with higher tumor grade, and were less likely to undergo surgical therapy than their Caucasian counterparts. Median survival time (MST) for the entire cohort was 32 months, while MST for AA patients was 20 months. Patients who received chemotherapy before surgery, surgery without chemotherapy, and surgery before chemotherapy demonstrated an independent, significantly improved outcome in comparison to patients who underwent chemotherapy without surgical extirpation. The administration of radiation therapy did not demonstrate an improvement in survival. By multivariate analysis, AA race (HR = 2.19) and failure to provide surgery (HR = 2.3) were independent predictors of worse prognosis. No effect of poverty or ethnicity on outcome was observed. Conclusions IBC carries a poor prognosis for all patients with significantly worse outcomes for AA women. Multimodality therapy provided the best survival rates.

Original languageEnglish (US)
Pages (from-to)631-641
Number of pages11
JournalBreast Cancer Research and Treatment
Volume117
Issue number3
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Inflammatory Breast Neoplasms
African Americans
Drug Therapy
Survival
Breast Neoplasms
Neoplasms
Poverty
Hispanic Americans
Social Class
Registries
Inpatients
Radiotherapy
Multivariate Analysis
Survival Rate
Therapeutics

Keywords

  • Breast cancer
  • Disparity
  • Outcomes
  • Race
  • Socioeconomic status

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A comprehensive evaluation of outcomes for inflammatory breast cancer. / Yang, Relin; Cheung, Michael C.; Hurley, Judith; Byrne, Margaret M.; Huang, Youjie; Zimmers, Teresa; Koniaris, Leonidas.

In: Breast Cancer Research and Treatment, Vol. 117, No. 3, 2009, p. 631-641.

Research output: Contribution to journalArticle

Yang, Relin ; Cheung, Michael C. ; Hurley, Judith ; Byrne, Margaret M. ; Huang, Youjie ; Zimmers, Teresa ; Koniaris, Leonidas. / A comprehensive evaluation of outcomes for inflammatory breast cancer. In: Breast Cancer Research and Treatment. 2009 ; Vol. 117, No. 3. pp. 631-641.
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