A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Frank Jessen, Rebecca E. Amariglio, Martin Van Boxtel, Monique Breteler, Mathieu Ceccaldi, Gaël Chételat, Bruno Dubois, Carole Dufouil, Kathryn A. Ellis, Wiesje M. Van Der Flier, Lidia Glodzik, Argonde C. Van Harten, Mony J. De Leon, Pauline McHugh, Michelle M. Mielke, Jose Luis Molinuevo, Lisa Mosconi, Ricardo S. Osorio, Audrey Perrotin, Ronald C. PetersenLaura A. Rabin, Lorena Rami, Barry Reisberg, Dorene M. Rentz, Perminder S. Sachdev, Vincent De La Sayette, Andrew Saykin, Philip Scheltens, Melanie B. Shulman, Melissa J. Slavin, Reisa A. Sperling, Robert Stewart, Olga Uspenskaya, Bruno Vellas, Pieter Jelle Visser, Michael Wagner

Research output: Contribution to journalArticle

595 Citations (Scopus)

Abstract

There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

Original languageEnglish
Pages (from-to)844-852
Number of pages9
JournalAlzheimer's and Dementia
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2014

Fingerprint

Alzheimer Disease
Research
Cognitive Dysfunction
Terminology
Consensus

Keywords

  • Alzheimer's disease
  • Mild cognitive impairment
  • Preclinical Alzheimer's disease
  • Prodromal Alzheimer 's disease
  • Research criteria
  • Subjective cognitive decline

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Jessen, F., Amariglio, R. E., Van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., ... Wagner, M. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's and Dementia, 10(6), 844-852. https://doi.org/10.1016/j.jalz.2014.01.001

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. / Jessen, Frank; Amariglio, Rebecca E.; Van Boxtel, Martin; Breteler, Monique; Ceccaldi, Mathieu; Chételat, Gaël; Dubois, Bruno; Dufouil, Carole; Ellis, Kathryn A.; Van Der Flier, Wiesje M.; Glodzik, Lidia; Van Harten, Argonde C.; De Leon, Mony J.; McHugh, Pauline; Mielke, Michelle M.; Molinuevo, Jose Luis; Mosconi, Lisa; Osorio, Ricardo S.; Perrotin, Audrey; Petersen, Ronald C.; Rabin, Laura A.; Rami, Lorena; Reisberg, Barry; Rentz, Dorene M.; Sachdev, Perminder S.; De La Sayette, Vincent; Saykin, Andrew; Scheltens, Philip; Shulman, Melanie B.; Slavin, Melissa J.; Sperling, Reisa A.; Stewart, Robert; Uspenskaya, Olga; Vellas, Bruno; Visser, Pieter Jelle; Wagner, Michael.

In: Alzheimer's and Dementia, Vol. 10, No. 6, 01.11.2014, p. 844-852.

Research output: Contribution to journalArticle

Jessen, F, Amariglio, RE, Van Boxtel, M, Breteler, M, Ceccaldi, M, Chételat, G, Dubois, B, Dufouil, C, Ellis, KA, Van Der Flier, WM, Glodzik, L, Van Harten, AC, De Leon, MJ, McHugh, P, Mielke, MM, Molinuevo, JL, Mosconi, L, Osorio, RS, Perrotin, A, Petersen, RC, Rabin, LA, Rami, L, Reisberg, B, Rentz, DM, Sachdev, PS, De La Sayette, V, Saykin, A, Scheltens, P, Shulman, MB, Slavin, MJ, Sperling, RA, Stewart, R, Uspenskaya, O, Vellas, B, Visser, PJ & Wagner, M 2014, 'A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease', Alzheimer's and Dementia, vol. 10, no. 6, pp. 844-852. https://doi.org/10.1016/j.jalz.2014.01.001
Jessen, Frank ; Amariglio, Rebecca E. ; Van Boxtel, Martin ; Breteler, Monique ; Ceccaldi, Mathieu ; Chételat, Gaël ; Dubois, Bruno ; Dufouil, Carole ; Ellis, Kathryn A. ; Van Der Flier, Wiesje M. ; Glodzik, Lidia ; Van Harten, Argonde C. ; De Leon, Mony J. ; McHugh, Pauline ; Mielke, Michelle M. ; Molinuevo, Jose Luis ; Mosconi, Lisa ; Osorio, Ricardo S. ; Perrotin, Audrey ; Petersen, Ronald C. ; Rabin, Laura A. ; Rami, Lorena ; Reisberg, Barry ; Rentz, Dorene M. ; Sachdev, Perminder S. ; De La Sayette, Vincent ; Saykin, Andrew ; Scheltens, Philip ; Shulman, Melanie B. ; Slavin, Melissa J. ; Sperling, Reisa A. ; Stewart, Robert ; Uspenskaya, Olga ; Vellas, Bruno ; Visser, Pieter Jelle ; Wagner, Michael. / A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. In: Alzheimer's and Dementia. 2014 ; Vol. 10, No. 6. pp. 844-852.
@article{62f7c77765d54bee93b3e85fa5496506,
title = "A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease",
abstract = "There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.",
keywords = "Alzheimer's disease, Mild cognitive impairment, Preclinical Alzheimer's disease, Prodromal Alzheimer 's disease, Research criteria, Subjective cognitive decline",
author = "Frank Jessen and Amariglio, {Rebecca E.} and {Van Boxtel}, Martin and Monique Breteler and Mathieu Ceccaldi and Ga{\"e}l Ch{\'e}telat and Bruno Dubois and Carole Dufouil and Ellis, {Kathryn A.} and {Van Der Flier}, {Wiesje M.} and Lidia Glodzik and {Van Harten}, {Argonde C.} and {De Leon}, {Mony J.} and Pauline McHugh and Mielke, {Michelle M.} and Molinuevo, {Jose Luis} and Lisa Mosconi and Osorio, {Ricardo S.} and Audrey Perrotin and Petersen, {Ronald C.} and Rabin, {Laura A.} and Lorena Rami and Barry Reisberg and Rentz, {Dorene M.} and Sachdev, {Perminder S.} and {De La Sayette}, Vincent and Andrew Saykin and Philip Scheltens and Shulman, {Melanie B.} and Slavin, {Melissa J.} and Sperling, {Reisa A.} and Robert Stewart and Olga Uspenskaya and Bruno Vellas and Visser, {Pieter Jelle} and Michael Wagner",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.jalz.2014.01.001",
language = "English",
volume = "10",
pages = "844--852",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

AU - Jessen, Frank

AU - Amariglio, Rebecca E.

AU - Van Boxtel, Martin

AU - Breteler, Monique

AU - Ceccaldi, Mathieu

AU - Chételat, Gaël

AU - Dubois, Bruno

AU - Dufouil, Carole

AU - Ellis, Kathryn A.

AU - Van Der Flier, Wiesje M.

AU - Glodzik, Lidia

AU - Van Harten, Argonde C.

AU - De Leon, Mony J.

AU - McHugh, Pauline

AU - Mielke, Michelle M.

AU - Molinuevo, Jose Luis

AU - Mosconi, Lisa

AU - Osorio, Ricardo S.

AU - Perrotin, Audrey

AU - Petersen, Ronald C.

AU - Rabin, Laura A.

AU - Rami, Lorena

AU - Reisberg, Barry

AU - Rentz, Dorene M.

AU - Sachdev, Perminder S.

AU - De La Sayette, Vincent

AU - Saykin, Andrew

AU - Scheltens, Philip

AU - Shulman, Melanie B.

AU - Slavin, Melissa J.

AU - Sperling, Reisa A.

AU - Stewart, Robert

AU - Uspenskaya, Olga

AU - Vellas, Bruno

AU - Visser, Pieter Jelle

AU - Wagner, Michael

PY - 2014/11/1

Y1 - 2014/11/1

N2 - There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

AB - There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

KW - Alzheimer's disease

KW - Mild cognitive impairment

KW - Preclinical Alzheimer's disease

KW - Prodromal Alzheimer 's disease

KW - Research criteria

KW - Subjective cognitive decline

UR - http://www.scopus.com/inward/record.url?scp=84927176303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927176303&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2014.01.001

DO - 10.1016/j.jalz.2014.01.001

M3 - Article

C2 - 24798886

AN - SCOPUS:84927176303

VL - 10

SP - 844

EP - 852

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 6

ER -