A controlled trial of erythromycin in adults with nonstreptococcal pharyngitis

Clement J. Mc Donald, William M. Tierney, Siu L. Hui, Morris L.V. French, Diane S. Leland, Robert B. Jones

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The local physician has long been maligned for profligate use of antibiotics in treating infections of the upper-respiratory-tract and pharyngitis. Academic medicine always 'knew' that the only important bacterial, and therefore treatable, cause of 'strep' pharyngitis was streptococcus. But the recent continued discovery of new and difficult-to-culture bacterial pathogens [1-3] reminds us that negative bacterial cultures do not prove the absence of a bacterial cause. Komaroff and his coworkers [4] found serological evidence of active infections with Chlamydia trachomatis and mycoplasma in 30% of adult patients with pharyngitis. Because these two organisms are in some circumstances susceptible to erythromycin, we hypothesize that erythromycin could reduce morbidity or the number of secondary cases or both in households of patients with nonstreptococcal pharyngitis (NSP). Thus, we initiated a double-blind, randomized, controlled trial of the efficacy of erythromycin base in adult patients with pharyngitis.

Original languageEnglish (US)
Pages (from-to)1093-1094
Number of pages2
JournalJournal of Infectious Diseases
Issue number5
StatePublished - Nov 1 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Mc Donald, C. J., Tierney, W. M., Hui, S. L., French, M. L. V., Leland, D. S., & Jones, R. B. (1985). A controlled trial of erythromycin in adults with nonstreptococcal pharyngitis. Journal of Infectious Diseases, 152(5), 1093-1094. https://doi.org/10.1093/infdis/152.5.1093