A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis

Xuan Liu, Qi-Huang Zheng, Gary Hutchins, Xiangshu Fei, Leonard C. Erickson, Kathy Miller, Bruce H. Mock, Barbara E. Glick-Wilson, Wendy L. Winkle, K. Lee Stone, Kathy A. Carlson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A convenient procedure by phase transfer catalysis has been developed for the synthesis of O6-BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.

Original languageEnglish
Pages (from-to)941-952
Number of pages12
JournalSynthetic Communications
Volume33
Issue number6
DOIs
StatePublished - 2003

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Catalysis
Derivatives
O(6)-benzylguanine

Keywords

  • O-Alkylguanine-DNA alkyltransferase
  • O-Benzylguanine derivatives
  • Phase transfer catalysis
  • Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis. / Liu, Xuan; Zheng, Qi-Huang; Hutchins, Gary; Fei, Xiangshu; Erickson, Leonard C.; Miller, Kathy; Mock, Bruce H.; Glick-Wilson, Barbara E.; Winkle, Wendy L.; Stone, K. Lee; Carlson, Kathy A.

In: Synthetic Communications, Vol. 33, No. 6, 2003, p. 941-952.

Research output: Contribution to journalArticle

Liu, X, Zheng, Q-H, Hutchins, G, Fei, X, Erickson, LC, Miller, K, Mock, BH, Glick-Wilson, BE, Winkle, WL, Stone, KL & Carlson, KA 2003, 'A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis', Synthetic Communications, vol. 33, no. 6, pp. 941-952. https://doi.org/10.1081/SCC-120016358
Liu, Xuan ; Zheng, Qi-Huang ; Hutchins, Gary ; Fei, Xiangshu ; Erickson, Leonard C. ; Miller, Kathy ; Mock, Bruce H. ; Glick-Wilson, Barbara E. ; Winkle, Wendy L. ; Stone, K. Lee ; Carlson, Kathy A. / A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis. In: Synthetic Communications. 2003 ; Vol. 33, No. 6. pp. 941-952.
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T1 - A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis

AU - Liu, Xuan

AU - Zheng, Qi-Huang

AU - Hutchins, Gary

AU - Fei, Xiangshu

AU - Erickson, Leonard C.

AU - Miller, Kathy

AU - Mock, Bruce H.

AU - Glick-Wilson, Barbara E.

AU - Winkle, Wendy L.

AU - Stone, K. Lee

AU - Carlson, Kathy A.

PY - 2003

Y1 - 2003

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AB - A convenient procedure by phase transfer catalysis has been developed for the synthesis of O6-BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.

KW - O-Alkylguanine-DNA alkyltransferase

KW - O-Benzylguanine derivatives

KW - Phase transfer catalysis

KW - Synthesis

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