A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis

Xuan Liu, Qi Huang Zheng, Gary D. Hutchins, Xiangshu Fei, Leonard C. Erickson, Kathy D. Miller, Bruce H. Mock, Barbara E. Glick-Wilson, Wendy L. Winkle, K. Lee Stone, Kathy A. Carlson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A convenient procedure by phase transfer catalysis has been developed for the synthesis of O6-BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.

Original languageEnglish (US)
Pages (from-to)941-952
Number of pages12
JournalSynthetic Communications
Volume33
Issue number6
DOIs
StatePublished - Jan 1 2003

Keywords

  • O-Alkylguanine-DNA alkyltransferase
  • O-Benzylguanine derivatives
  • Phase transfer catalysis
  • Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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    Liu, X., Zheng, Q. H., Hutchins, G. D., Fei, X., Erickson, L. C., Miller, K. D., Mock, B. H., Glick-Wilson, B. E., Winkle, W. L., Stone, K. L., & Carlson, K. A. (2003). A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis. Synthetic Communications, 33(6), 941-952. https://doi.org/10.1081/SCC-120016358