A convenient route to [68Ga]Ga-MAA for use as a particulate PET perfusion tracer

Carla J. Mathias, Mark Green

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A convenient method is described for compounding [68Ga]Ga-MAA (MAA=macroaggregated human serum albumin) with the eluate of a commercially available TiO2-based 68Ge/68Ga generator. The final [68Ga]Ga-MAA product was obtained with an 81.6±5.3% decay-corrected radiochemical yield and a radiochemical purity of 99.8±0.1% (n=5). Microscopic examination showed the [68Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [68Ga]Ga-MAA suspension, could be completed in 25 min. Only 4.4±0.9% of the total 68Ge breakthrough remaining associated with the final [68Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [68Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.

Original languageEnglish (US)
Pages (from-to)1910-1912
Number of pages3
JournalApplied Radiation and Isotopes
Volume66
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

particulates
tracers
Perfusion
routes
compounding
products
generators
elution
albumins
serums
delivery
purity
examination
Particle Size
Serum Albumin
preparation
gallium macroaggregated human serum albumin
Suspensions
decay

Keywords

  • Gallium-68
  • Macroaggregated human serum albumin (MAA)
  • Perfusion
  • PET

ASJC Scopus subject areas

  • Radiation
  • Medicine(all)

Cite this

A convenient route to [68Ga]Ga-MAA for use as a particulate PET perfusion tracer. / Mathias, Carla J.; Green, Mark.

In: Applied Radiation and Isotopes, Vol. 66, No. 12, 12.2008, p. 1910-1912.

Research output: Contribution to journalArticle

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abstract = "A convenient method is described for compounding [68Ga]Ga-MAA (MAA=macroaggregated human serum albumin) with the eluate of a commercially available TiO2-based 68Ge/68Ga generator. The final [68Ga]Ga-MAA product was obtained with an 81.6±5.3{\%} decay-corrected radiochemical yield and a radiochemical purity of 99.8±0.1{\%} (n=5). Microscopic examination showed the [68Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [68Ga]Ga-MAA suspension, could be completed in 25 min. Only 4.4±0.9{\%} of the total 68Ge breakthrough remaining associated with the final [68Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [68Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.",
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