A convenient route to [68Ga]Ga-MAA for use as a particulate PET perfusion tracer

Carla J. Mathias, Mark A. Green

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A convenient method is described for compounding [68Ga]Ga-MAA (MAA=macroaggregated human serum albumin) with the eluate of a commercially available TiO2-based 68Ge/68Ga generator. The final [68Ga]Ga-MAA product was obtained with an 81.6±5.3% decay-corrected radiochemical yield and a radiochemical purity of 99.8±0.1% (n=5). Microscopic examination showed the [68Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [68Ga]Ga-MAA suspension, could be completed in 25 min. Only 4.4±0.9% of the total 68Ge breakthrough remaining associated with the final [68Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [68Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.

Original languageEnglish (US)
Pages (from-to)1910-1912
Number of pages3
JournalApplied Radiation and Isotopes
Volume66
Issue number12
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Keywords

  • Gallium-68
  • Macroaggregated human serum albumin (MAA)
  • PET
  • Perfusion

ASJC Scopus subject areas

  • Radiation

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