A Cumulative Shear Mechanism for Tissue Damage Initiation in Shock-Wave Lithotripsy

Jonathan B. Freund, Tim Colonius, Andrew Evan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Evidence suggests that inertial cavitation plays an important role in the renal injury incurred during shock-wave lithotripsy. However, it is unclear how tissue damage is initiated, and significant injury typically occurs only after a sufficient dose of shock waves. Although it has been suggested that shock-induced shearing might initiate injury, estimates indicate that individual shocks do not produce sufficient shear to do so. In this paper, we hypothesize that the cumulative shear of the many shocks is damaging. This mechanism depends on whether there is sufficient time between shocks for tissue to relax to its unstrained state. We investigate the mechanism with a physics-based simulation model, wherein the basement membranes that define the tubules and vessels in the inner medulla are represented as elastic shells surrounded by viscous fluid. Material properties are estimated from in-vitro tests of renal basement membranes and documented mechanical properties of cells and extracellular gels. Estimates for the net shear deformation from a typical lithotripter shock (∼0.1%) are found from a separate dynamic shock simulation. The results suggest that the larger interstitial volume (∼40%) near the papilla tip gives the tissue there a relaxation time comparable to clinical shock delivery rates (∼1 Hz), thus allowing shear to accumulate. Away from the papilla tip, where the interstitial volume is smaller (∼20%), the model tissue relaxes completely before the next shock would be delivered. Implications of the model are that slower delivery rates and broader focal zones should both decrease injury, consistent with some recent observations. (E-mail: jbfreund@uiuc.edu).

Original languageEnglish
Pages (from-to)1495-1503
Number of pages9
JournalUltrasound in Medicine and Biology
Volume33
Issue number9
DOIs
StatePublished - Sep 2007

Fingerprint

Lithotripsy
shock waves
Shock
shock
shear
damage
papillae
basements
Wounds and Injuries
Basement Membrane
delivery
interstitials
membranes
elastic shells
Kidney
viscous fluids
estimates
cavitation flow
shearing
Physics

Keywords

  • Numerical simulation
  • Renal injury
  • Shock-wave lithotripsy
  • Tissue damage

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

A Cumulative Shear Mechanism for Tissue Damage Initiation in Shock-Wave Lithotripsy. / Freund, Jonathan B.; Colonius, Tim; Evan, Andrew.

In: Ultrasound in Medicine and Biology, Vol. 33, No. 9, 09.2007, p. 1495-1503.

Research output: Contribution to journalArticle

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