A decade of epigenetic research in Toxoplasma gondii

Stacy E. Dixon, Krista L. Stilger, Eliana V. Elias, Arunasalam Naguleswaran, William J. Sullivan

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

In the past 10 years, the field of parasitology has witnessed an explosion of studies investigating gene regulation. In this review, we will describe recent advances largely stemming from the study of Toxoplasma gondii, a significant opportunistic pathogen and useful model for other apicomplexan protozoa. Surprising findings have emerged, including the discovery of a wealth of epigenetic machinery in these primitive eukaryotes, unusual histone variants, and a battery of plant-like transcription factors. We will elaborate on how these unusual features impact parasite physiology and potential therapeutics as we summarize some of the key discoveries from the last decade. We will close by proposing a few questions to address in the next 10 years.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalMolecular and Biochemical Parasitology
Volume173
Issue number1
DOIs
StatePublished - Sep 1 2010

Keywords

  • Apicomplexa
  • Chromatin
  • Differentiation
  • Histone
  • Parasite
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Parasitology

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