A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF

Weiguo Zhu, Sam M. Galoyan, Jeffrey C. Petruska, Gerry S. Oxford, Lorne M. Mendell

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4-P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development and differences in the signaling pathways mediating bradykinin-and NGF-induced sensitization.

Original languageEnglish (US)
Pages (from-to)3148-3152
Number of pages5
JournalJournal of Neurophysiology
Volume92
Issue number5
DOIs
StatePublished - Nov 1 2004

Fingerprint

Capsaicin
Spinal Ganglia
Nerve Growth Factor
Heating
Neurons
Hot Temperature
Bradykinin
trkA Receptor
Nociceptors
Hyperalgesia
Signal Transduction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF. / Zhu, Weiguo; Galoyan, Sam M.; Petruska, Jeffrey C.; Oxford, Gerry S.; Mendell, Lorne M.

In: Journal of Neurophysiology, Vol. 92, No. 5, 01.11.2004, p. 3148-3152.

Research output: Contribution to journalArticle

Zhu, Weiguo ; Galoyan, Sam M. ; Petruska, Jeffrey C. ; Oxford, Gerry S. ; Mendell, Lorne M. / A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF. In: Journal of Neurophysiology. 2004 ; Vol. 92, No. 5. pp. 3148-3152.
@article{f9b857a605904c9f9fd510fd582df336,
title = "A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF",
abstract = "Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4-P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development and differences in the signaling pathways mediating bradykinin-and NGF-induced sensitization.",
author = "Weiguo Zhu and Galoyan, {Sam M.} and Petruska, {Jeffrey C.} and Oxford, {Gerry S.} and Mendell, {Lorne M.}",
year = "2004",
month = "11",
day = "1",
doi = "10.1152/jn.00356.2004",
language = "English (US)",
volume = "92",
pages = "3148--3152",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF

AU - Zhu, Weiguo

AU - Galoyan, Sam M.

AU - Petruska, Jeffrey C.

AU - Oxford, Gerry S.

AU - Mendell, Lorne M.

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4-P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development and differences in the signaling pathways mediating bradykinin-and NGF-induced sensitization.

AB - Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4-P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development and differences in the signaling pathways mediating bradykinin-and NGF-induced sensitization.

UR - http://www.scopus.com/inward/record.url?scp=14844303990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14844303990&partnerID=8YFLogxK

U2 - 10.1152/jn.00356.2004

DO - 10.1152/jn.00356.2004

M3 - Article

C2 - 15201308

AN - SCOPUS:14844303990

VL - 92

SP - 3148

EP - 3152

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 5

ER -