A double-masked randomized trial of postoperative local anesthetic for pain control in pediatric strabismus surgery

Laura B. Enyedi, David K. Wallace, Guy de L Dear

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose To determine to what extent local anesthetic reduces postoperative pain after pediatric strabismus surgery. Methods In this double-masked, randomized clinical trial of 50 children 13-91 months of age undergoing strabismus surgery, subjects were randomly assigned to one of three treatments given at the conclusion of surgery: topical lidocaine gel and sub-Tenon's (balanced salt solution) placebo (n = 16), topical placebo (hypromellose) and sub-Tenon's bupivacaine 0.75% (n = 17), or topical and sub-Tenon's placebo (n = 17). Pain was otherwise managed systemically in the usual fashion by the masked anesthesia team and assessed at regular postoperative intervals by a masked observer using an objective, validated pain scale. Results Average pain in the first 30 minutes was 6.57, 6.36, and 6.58 in the lidocaine, bupivacaine, and placebo groups, respectively, and was significantly lower (P = 0.016) for bupivacaine vs placebo. The bupivacaine group had significantly lower scores for pain after 30 minutes, total pain, and peak pain versus the lidocaine group. Conclusions Sub-Tenon's bupivacaine may reduce postoperative pain in children undergoing strabismus surgery.[Figure presented]

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalJournal of AAPOS
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

Strabismus
Local Anesthetics
Bupivacaine
Pediatrics
Pain
Placebos
Lidocaine
Postoperative Pain
Double-Blind Method
Anesthesia
Randomized Controlled Trials
Salts
Gels

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

A double-masked randomized trial of postoperative local anesthetic for pain control in pediatric strabismus surgery. / Enyedi, Laura B.; Wallace, David K.; de L Dear, Guy.

In: Journal of AAPOS, Vol. 21, No. 2, 01.04.2017, p. 107-111.

Research output: Contribution to journalArticle

@article{0be517fd3dc44d089cf002bfe3d83c39,
title = "A double-masked randomized trial of postoperative local anesthetic for pain control in pediatric strabismus surgery",
abstract = "Purpose To determine to what extent local anesthetic reduces postoperative pain after pediatric strabismus surgery. Methods In this double-masked, randomized clinical trial of 50 children 13-91 months of age undergoing strabismus surgery, subjects were randomly assigned to one of three treatments given at the conclusion of surgery: topical lidocaine gel and sub-Tenon's (balanced salt solution) placebo (n = 16), topical placebo (hypromellose) and sub-Tenon's bupivacaine 0.75{\%} (n = 17), or topical and sub-Tenon's placebo (n = 17). Pain was otherwise managed systemically in the usual fashion by the masked anesthesia team and assessed at regular postoperative intervals by a masked observer using an objective, validated pain scale. Results Average pain in the first 30 minutes was 6.57, 6.36, and 6.58 in the lidocaine, bupivacaine, and placebo groups, respectively, and was significantly lower (P = 0.016) for bupivacaine vs placebo. The bupivacaine group had significantly lower scores for pain after 30 minutes, total pain, and peak pain versus the lidocaine group. Conclusions Sub-Tenon's bupivacaine may reduce postoperative pain in children undergoing strabismus surgery.[Figure presented]",
author = "Enyedi, {Laura B.} and Wallace, {David K.} and {de L Dear}, Guy",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.jaapos.2017.03.005",
language = "English (US)",
volume = "21",
pages = "107--111",
journal = "Journal of AAPOS",
issn = "1091-8531",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - A double-masked randomized trial of postoperative local anesthetic for pain control in pediatric strabismus surgery

AU - Enyedi, Laura B.

AU - Wallace, David K.

AU - de L Dear, Guy

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Purpose To determine to what extent local anesthetic reduces postoperative pain after pediatric strabismus surgery. Methods In this double-masked, randomized clinical trial of 50 children 13-91 months of age undergoing strabismus surgery, subjects were randomly assigned to one of three treatments given at the conclusion of surgery: topical lidocaine gel and sub-Tenon's (balanced salt solution) placebo (n = 16), topical placebo (hypromellose) and sub-Tenon's bupivacaine 0.75% (n = 17), or topical and sub-Tenon's placebo (n = 17). Pain was otherwise managed systemically in the usual fashion by the masked anesthesia team and assessed at regular postoperative intervals by a masked observer using an objective, validated pain scale. Results Average pain in the first 30 minutes was 6.57, 6.36, and 6.58 in the lidocaine, bupivacaine, and placebo groups, respectively, and was significantly lower (P = 0.016) for bupivacaine vs placebo. The bupivacaine group had significantly lower scores for pain after 30 minutes, total pain, and peak pain versus the lidocaine group. Conclusions Sub-Tenon's bupivacaine may reduce postoperative pain in children undergoing strabismus surgery.[Figure presented]

AB - Purpose To determine to what extent local anesthetic reduces postoperative pain after pediatric strabismus surgery. Methods In this double-masked, randomized clinical trial of 50 children 13-91 months of age undergoing strabismus surgery, subjects were randomly assigned to one of three treatments given at the conclusion of surgery: topical lidocaine gel and sub-Tenon's (balanced salt solution) placebo (n = 16), topical placebo (hypromellose) and sub-Tenon's bupivacaine 0.75% (n = 17), or topical and sub-Tenon's placebo (n = 17). Pain was otherwise managed systemically in the usual fashion by the masked anesthesia team and assessed at regular postoperative intervals by a masked observer using an objective, validated pain scale. Results Average pain in the first 30 minutes was 6.57, 6.36, and 6.58 in the lidocaine, bupivacaine, and placebo groups, respectively, and was significantly lower (P = 0.016) for bupivacaine vs placebo. The bupivacaine group had significantly lower scores for pain after 30 minutes, total pain, and peak pain versus the lidocaine group. Conclusions Sub-Tenon's bupivacaine may reduce postoperative pain in children undergoing strabismus surgery.[Figure presented]

UR - http://www.scopus.com/inward/record.url?scp=85017099577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017099577&partnerID=8YFLogxK

U2 - 10.1016/j.jaapos.2017.03.005

DO - 10.1016/j.jaapos.2017.03.005

M3 - Article

VL - 21

SP - 107

EP - 111

JO - Journal of AAPOS

JF - Journal of AAPOS

SN - 1091-8531

IS - 2

ER -