A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism

Howard J. Edenberg, Tatiana Foroud, Daniel L. Koller, Alison Goate, John Rice, Paul Van Eerdewegh, Theodore Reich, C. Robert Cloninger, John I. Nurnberger, Maria Kowalczuk, Bo Wu, T. K. Li, P. M. Conneally, Jay A. Tischfield, William Wu, Shantia Shears, Raymond Crowe, Victor Hesselbrock, Marc Schuckit, Bernice PorjeszHenri Begleiter

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

The possible association of the DRD2 locus, and in particular the Taql- A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.

Original languageEnglish (US)
Pages (from-to)505-512
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number2
DOIs
StatePublished - 1998

Keywords

  • Alcoholism
  • Association Study
  • Dopamine D2 Receptor
  • Family Study

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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    Edenberg, H. J., Foroud, T., Koller, D. L., Goate, A., Rice, J., Van Eerdewegh, P., Reich, T., Cloninger, C. R., Nurnberger, J. I., Kowalczuk, M., Wu, B., Li, T. K., Conneally, P. M., Tischfield, J. A., Wu, W., Shears, S., Crowe, R., Hesselbrock, V., Schuckit, M., ... Begleiter, H. (1998). A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. Alcoholism: Clinical and Experimental Research, 22(2), 505-512. https://doi.org/10.1111/j.1530-0277.1998.tb03680.x