A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence

Howard J. Edenberg, Jennifer Reynolds, Daniel L. Koller, Henri Begleiter, Kathleen K. Bucholz, P. Michael Conneally, Raymond Crowe, Alison Goate, Victor Hesselbrock, T. K. Li, John I. Nurnberger, Bernice Porjesz, Theodore Reich, John P. Rice, Marc Schuckit, Jay A. Tischfield, Tatiana Foroud

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.

Original languageEnglish (US)
Pages (from-to)1080-1085
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number5
DOIs
StatePublished - Aug 1998

Keywords

  • Alcoholism
  • Association Study
  • Functional Promoter Polymorphism
  • Linkage Analysis
  • Serotonin Transporter

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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