A family cluster of five cases of group A streptococcal pneumonia.

Sumita Roy, John R. Schreiber, Chandy C. John, Edward L. Kaplan, Benigno Rodriguez, Robert A. Salata, Chandy John

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A cluster of 5 family members, a mother and 4 children, were hospitalized for severe group A Streptococcus (GAS) pneumonia. Three family members had complications: sepsis (1), empyema (2), and a sterile parapneumonic effusion (1). Two additional family members had symptoms of upper respiratory tract infection, and 1 was hospitalized for these symptoms. GAS was isolated from the blood of 1 patient, the pleural fluid of 2 patients, and the oropharynx of 6 patients. Pulsed field gel electrophoresis testing revealed an identical deoxyribonucleic acid pattern in all 7 isolates. Genotyping revealed the speA gene and serotyping the T-1, M-1 serotype in all isolates. This family cluster of invasive GAS disease is the largest reported to date, with an attack rate of 41.7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease.

Original languageEnglish (US)
JournalPediatrics
Volume112
Issue number1 Pt 1
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Pneumonia
Streptococcus
Serotyping
Oropharynx
Empyema
Hospitalized Child
Antibiotic Prophylaxis
Pulsed Field Gel Electrophoresis
Streptococcus pneumoniae
Respiratory Tract Infections
Sepsis
Mothers
DNA
Genes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Roy, S., Schreiber, J. R., John, C. C., Kaplan, E. L., Rodriguez, B., Salata, R. A., & John, C. (2003). A family cluster of five cases of group A streptococcal pneumonia. Pediatrics, 112(1 Pt 1).

A family cluster of five cases of group A streptococcal pneumonia. / Roy, Sumita; Schreiber, John R.; John, Chandy C.; Kaplan, Edward L.; Rodriguez, Benigno; Salata, Robert A.; John, Chandy.

In: Pediatrics, Vol. 112, No. 1 Pt 1, 07.2003.

Research output: Contribution to journalArticle

Roy, S, Schreiber, JR, John, CC, Kaplan, EL, Rodriguez, B, Salata, RA & John, C 2003, 'A family cluster of five cases of group A streptococcal pneumonia.', Pediatrics, vol. 112, no. 1 Pt 1.
Roy S, Schreiber JR, John CC, Kaplan EL, Rodriguez B, Salata RA et al. A family cluster of five cases of group A streptococcal pneumonia. Pediatrics. 2003 Jul;112(1 Pt 1).
Roy, Sumita ; Schreiber, John R. ; John, Chandy C. ; Kaplan, Edward L. ; Rodriguez, Benigno ; Salata, Robert A. ; John, Chandy. / A family cluster of five cases of group A streptococcal pneumonia. In: Pediatrics. 2003 ; Vol. 112, No. 1 Pt 1.
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