A family study of rapid-cycling bipolar illness

John Nurnberger, Juliet J. Guroff, Joel Hamovit, Wade Berrettini, Elliot Gershon

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Twenty-nine out of 195 bipolar/episodic schizoaffective patients were judged to be rapid-cyclers (15%). Twenty-five of the 29 were female (86%). The age-corrected morbid risk for major affective disorder was 23.5% in 179 relatives of rapid-cyclers and 31.0% in 189 relatives of matched non-rapid cyclers (x2 = 2.6, NS). The prevalence of rapid-cycling itself was also not different in the two groups of relatives. Rapid-cycling thus appears to arise from factors which are separable from the genetic vulnerability to bipolar illness and which do not lead to aggregation within families.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalJournal of Affective Disorders
Volume15
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Mood Disorders

Keywords

  • Bipolar illness
  • Family study
  • Rapid-cycling

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Psychology(all)
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

A family study of rapid-cycling bipolar illness. / Nurnberger, John; Guroff, Juliet J.; Hamovit, Joel; Berrettini, Wade; Gershon, Elliot.

In: Journal of Affective Disorders, Vol. 15, No. 1, 1988, p. 87-91.

Research output: Contribution to journalArticle

Nurnberger, J, Guroff, JJ, Hamovit, J, Berrettini, W & Gershon, E 1988, 'A family study of rapid-cycling bipolar illness', Journal of Affective Disorders, vol. 15, no. 1, pp. 87-91. https://doi.org/10.1016/0165-0327(88)90013-4
Nurnberger, John ; Guroff, Juliet J. ; Hamovit, Joel ; Berrettini, Wade ; Gershon, Elliot. / A family study of rapid-cycling bipolar illness. In: Journal of Affective Disorders. 1988 ; Vol. 15, No. 1. pp. 87-91.
@article{75490a032d844aaa85d070e79d95ba31,
title = "A family study of rapid-cycling bipolar illness",
abstract = "Twenty-nine out of 195 bipolar/episodic schizoaffective patients were judged to be rapid-cyclers (15{\%}). Twenty-five of the 29 were female (86{\%}). The age-corrected morbid risk for major affective disorder was 23.5{\%} in 179 relatives of rapid-cyclers and 31.0{\%} in 189 relatives of matched non-rapid cyclers (x2 = 2.6, NS). The prevalence of rapid-cycling itself was also not different in the two groups of relatives. Rapid-cycling thus appears to arise from factors which are separable from the genetic vulnerability to bipolar illness and which do not lead to aggregation within families.",
keywords = "Bipolar illness, Family study, Rapid-cycling",
author = "John Nurnberger and Guroff, {Juliet J.} and Joel Hamovit and Wade Berrettini and Elliot Gershon",
year = "1988",
doi = "10.1016/0165-0327(88)90013-4",
language = "English (US)",
volume = "15",
pages = "87--91",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - A family study of rapid-cycling bipolar illness

AU - Nurnberger, John

AU - Guroff, Juliet J.

AU - Hamovit, Joel

AU - Berrettini, Wade

AU - Gershon, Elliot

PY - 1988

Y1 - 1988

N2 - Twenty-nine out of 195 bipolar/episodic schizoaffective patients were judged to be rapid-cyclers (15%). Twenty-five of the 29 were female (86%). The age-corrected morbid risk for major affective disorder was 23.5% in 179 relatives of rapid-cyclers and 31.0% in 189 relatives of matched non-rapid cyclers (x2 = 2.6, NS). The prevalence of rapid-cycling itself was also not different in the two groups of relatives. Rapid-cycling thus appears to arise from factors which are separable from the genetic vulnerability to bipolar illness and which do not lead to aggregation within families.

AB - Twenty-nine out of 195 bipolar/episodic schizoaffective patients were judged to be rapid-cyclers (15%). Twenty-five of the 29 were female (86%). The age-corrected morbid risk for major affective disorder was 23.5% in 179 relatives of rapid-cyclers and 31.0% in 189 relatives of matched non-rapid cyclers (x2 = 2.6, NS). The prevalence of rapid-cycling itself was also not different in the two groups of relatives. Rapid-cycling thus appears to arise from factors which are separable from the genetic vulnerability to bipolar illness and which do not lead to aggregation within families.

KW - Bipolar illness

KW - Family study

KW - Rapid-cycling

UR - http://www.scopus.com/inward/record.url?scp=0024044504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024044504&partnerID=8YFLogxK

U2 - 10.1016/0165-0327(88)90013-4

DO - 10.1016/0165-0327(88)90013-4

M3 - Article

VL - 15

SP - 87

EP - 91

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1

ER -