A family study of rapid-cycling bipolar illness

John Nurnberger, Juliet J. Guroff, Joel Hamovit, Wade Berrettini, Elliot Gershon

Research output: Contribution to journalArticle

53 Scopus citations


Twenty-nine out of 195 bipolar/episodic schizoaffective patients were judged to be rapid-cyclers (15%). Twenty-five of the 29 were female (86%). The age-corrected morbid risk for major affective disorder was 23.5% in 179 relatives of rapid-cyclers and 31.0% in 189 relatives of matched non-rapid cyclers (x2 = 2.6, NS). The prevalence of rapid-cycling itself was also not different in the two groups of relatives. Rapid-cycling thus appears to arise from factors which are separable from the genetic vulnerability to bipolar illness and which do not lead to aggregation within families.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalJournal of Affective Disorders
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes


  • Bipolar illness
  • Family study
  • Rapid-cycling

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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