A finite state model for respiratory motion analysis in image guided radiation therapy

Huanmei Wu, Gregory C. Sharp, Betty Salzberg, David Kaeli, Hiroki Shirato, Steve B. Jiang

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Effective image guided radiation treatment of a moving tumour requires adequate information on respiratory motion characteristics. For margin expansion, beam tracking and respiratory gating, the tumour motion must be quantified for pretreatment planning and monitored on-line. We propose a finite state model for respiratory motion analysis that captures our natural understanding of breathing stages. In this model, a regular breathing cycle is represented by three line segments, exhale, end-of-exhale and inhale, while abnormal breathing is represented by an irregular breathing state. In addition, we describe an on-line implementation of this model in one dimension. We found this model can accurately characterize a wide variety of patient breathing patterns. This model was used to describe the respiratory motion for 23 patients with peak-to-peak motion greater than 7 mm. The average root mean square error over all patients was less than 1 mm and no patient has an error worse than 1.5 mm. Our model provides a convenient tool to quantify respiratory motion characteristics, such as patterns of frequency changes and amplitude changes, and can be applied to internal or external motion, including internal tumour position, abdominal surface, diaphragm, spirometry and other surrogates.

Original languageEnglish (US)
Pages (from-to)5357-5372
Number of pages16
JournalPhysics in Medicine and Biology
Volume49
Issue number23
DOIs
StatePublished - Dec 7 2004
Externally publishedYes

Fingerprint

Image-Guided Radiotherapy
Radiotherapy
radiation therapy
breathing
Respiration
Tumors
tumors
Particle beam tracking
Neoplasms
Diaphragms
root-mean-square errors
Spirometry
Mean square error
diaphragms
Diaphragm
Motion analysis
pretreatment
planning
margins
Radiation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A finite state model for respiratory motion analysis in image guided radiation therapy. / Wu, Huanmei; Sharp, Gregory C.; Salzberg, Betty; Kaeli, David; Shirato, Hiroki; Jiang, Steve B.

In: Physics in Medicine and Biology, Vol. 49, No. 23, 07.12.2004, p. 5357-5372.

Research output: Contribution to journalArticle

Wu, Huanmei ; Sharp, Gregory C. ; Salzberg, Betty ; Kaeli, David ; Shirato, Hiroki ; Jiang, Steve B. / A finite state model for respiratory motion analysis in image guided radiation therapy. In: Physics in Medicine and Biology. 2004 ; Vol. 49, No. 23. pp. 5357-5372.
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