A framework for 3D analysis of facial morphology in fetal alcohol syndrome

Jing Wan, Li Shen, Shiaofen Fang, Jason McLaughlin, Ilona Autti-Rämö, Åse Fagerlund, Edward Riley, H. Eugene Hoyme, Elizabeth S. Moore, Tatiana Foroud

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Surface-based morphometry (SBM) is widely used in biomedical imaging and other domains to localize shape changes related to different conditions. This paper presents a computational framework that integrates a set of effective surface registration and analysis methods to form a unified SBM processing pipeline. Surface registration includes two parts: surface alignment in the object space by employing the iterative closest point (ICP) method, and surface alignment in the parameter space by using conformal mapping and landmark-based thin-plate spline methods. Statistical group analysis of registered surface data is then conducted by surface-based general linear model and random field theory addressing multiple testing issues. The effectiveness of the proposed framework is demonstrated by applying it to a fetal alcohol syndrome (FAS) study for identifying facial dysmorphology in FAS patients.

Original languageEnglish (US)
Title of host publicationMedical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings
Pages118-127
Number of pages10
DOIs
StatePublished - Nov 9 2010
Event5th International Workshop on Medical Imaging and Augmented Reality, MIAR 2010 - Beijing, China
Duration: Sep 19 2010Sep 20 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6326 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other5th International Workshop on Medical Imaging and Augmented Reality, MIAR 2010
CountryChina
CityBeijing
Period9/19/109/20/10

Fingerprint

Alcohol
Alcohols
Morphometry
Registration
Alignment
Biomedical Imaging
Thin-plate Spline
Conformal mapping
Multiple Testing
Framework
Conformal Mapping
Landmarks
Splines
Random Field
Field Theory
Parameter Space
Linear Model
Pipelines
Integrate
Imaging techniques

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Wan, J., Shen, L., Fang, S., McLaughlin, J., Autti-Rämö, I., Fagerlund, Å., ... Foroud, T. (2010). A framework for 3D analysis of facial morphology in fetal alcohol syndrome. In Medical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings (pp. 118-127). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6326 LNCS). https://doi.org/10.1007/978-3-642-15699-1_13

A framework for 3D analysis of facial morphology in fetal alcohol syndrome. / Wan, Jing; Shen, Li; Fang, Shiaofen; McLaughlin, Jason; Autti-Rämö, Ilona; Fagerlund, Åse; Riley, Edward; Hoyme, H. Eugene; Moore, Elizabeth S.; Foroud, Tatiana.

Medical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings. 2010. p. 118-127 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6326 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wan, J, Shen, L, Fang, S, McLaughlin, J, Autti-Rämö, I, Fagerlund, Å, Riley, E, Hoyme, HE, Moore, ES & Foroud, T 2010, A framework for 3D analysis of facial morphology in fetal alcohol syndrome. in Medical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 6326 LNCS, pp. 118-127, 5th International Workshop on Medical Imaging and Augmented Reality, MIAR 2010, Beijing, China, 9/19/10. https://doi.org/10.1007/978-3-642-15699-1_13
Wan J, Shen L, Fang S, McLaughlin J, Autti-Rämö I, Fagerlund Å et al. A framework for 3D analysis of facial morphology in fetal alcohol syndrome. In Medical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings. 2010. p. 118-127. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-642-15699-1_13
Wan, Jing ; Shen, Li ; Fang, Shiaofen ; McLaughlin, Jason ; Autti-Rämö, Ilona ; Fagerlund, Åse ; Riley, Edward ; Hoyme, H. Eugene ; Moore, Elizabeth S. ; Foroud, Tatiana. / A framework for 3D analysis of facial morphology in fetal alcohol syndrome. Medical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings. 2010. pp. 118-127 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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