A frequency analysis of behavior components of the serotonin syndrome produced by p-chloroamphetamine

Charles L. Kutscher, Bryan Yamamoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A time-sampling frequency analysis was made of criterion behaviors following injection of 2.5-10 mg/kg dosages of p-chloroamphetamine (PCA). Stereotypic behaviors (forepaw treading, circling, head weaving and inching) increased with increasing dosages and normal behaviors (grooming, rearing, and instances of inactivity) decreased. Composite scores of stereotypic behavior were a positive, linear function of PCA dosage. Composite scores of normal behavior showed near maximal inhibition at 5 mg/kg. Splayed hindlimbs is a reliable and sensitive indicator of PCA action, but vocalization, tremors, diarrhea and autonomic signs are not. Preinjection of PCA strongly attenuated the PCA-induced syndrome, as expected, since the preinjection should deplete brain serotonin and reduce the amount released by the second PCA injection.

Original languageEnglish (US)
Pages (from-to)611-616
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume11
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

p-Chloroamphetamine
Serotonin Syndrome
Serotonin
Grooming
Injections
Composite materials
Tremor
Hindlimb
Diarrhea
Brain
Head
Sampling

Keywords

  • Halogenated amphetamine
  • Neurotransmitters
  • p-Chloroamphetamine (PCA)
  • Serotonin
  • Stereotypy

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

A frequency analysis of behavior components of the serotonin syndrome produced by p-chloroamphetamine. / Kutscher, Charles L.; Yamamoto, Bryan.

In: Pharmacology, Biochemistry and Behavior, Vol. 11, No. 6, 1979, p. 611-616.

Research output: Contribution to journalArticle

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