A frequency analysis of behavior components of the serotonin syndrome produced by p-chloroamphetamine

Charles L. Kutscher, Bryan K. Yamamoto

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A time-sampling frequency analysis was made of criterion behaviors following injection of 2.5-10 mg/kg dosages of p-chloroamphetamine (PCA). Stereotypic behaviors (forepaw treading, circling, head weaving and inching) increased with increasing dosages and normal behaviors (grooming, rearing, and instances of inactivity) decreased. Composite scores of stereotypic behavior were a positive, linear function of PCA dosage. Composite scores of normal behavior showed near maximal inhibition at 5 mg/kg. Splayed hindlimbs is a reliable and sensitive indicator of PCA action, but vocalization, tremors, diarrhea and autonomic signs are not. Preinjection of PCA strongly attenuated the PCA-induced syndrome, as expected, since the preinjection should deplete brain serotonin and reduce the amount released by the second PCA injection.

Original languageEnglish (US)
Pages (from-to)611-616
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number6
StatePublished - Dec 1979
Externally publishedYes


  • Halogenated amphetamine
  • Neurotransmitters
  • Serotonin
  • Stereotypy
  • p-Chloroamphetamine (PCA)

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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