A functional factor X deficiency

Paul Sun, Jane Hata, John Bauer, Carolyn Haibach, Doug Campbell, Medhi Farhangi, Dan Smith

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A functional factor X deficiency is described which caused pronounced reduction in the in vitro activation of the extrinsic system while marginally affecting the in vitro activation of the intrinsic pathway. All studies were normal with the exception of a prolonged PT, an elevated factor X antigen, and low factor X activity. Western blot analysis revealed the presence of two factor X species. The abnormal molecule was of higher molecular weight. Interestingly, there was no bleeding associated with this deficiency. The biochemical basis of this defect is currently under investigation. ©1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalAmerican Journal of Hematology
Volume48
Issue number1
DOIs
StatePublished - Jan 1995
Externally publishedYes

Keywords

  • coagulation factor deficiency
  • factor X

ASJC Scopus subject areas

  • Hematology

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    Sun, P., Hata, J., Bauer, J., Haibach, C., Campbell, D., Farhangi, M., & Smith, D. (1995). A functional factor X deficiency. American Journal of Hematology, 48(1), 1-4. https://doi.org/10.1002/ajh.2830480102