A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic

Philip L. Johnson, Stafford L. Lightman, Christopher A. Lowry

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The ability of serotonin (5-HT) to facilitate or attenuate autonomic, endocrine, and behavioral responses to stressful stimuli has received much attention. The effects of 5-HT on physiologic and behavioral responses to stressful stimuli seem to depend on the brain region where it is released and the effector system it acts upon. This and the distinct morphology and topographic organization of subpopulations of serotonergic neurons have led to the hypothesis that subpopulations of serotonergic neurons are functionally distinct. Serotonin's role as a modulator of the "fight-or-flight" response is mediated in part by 5-HT release in the dorsolateral periaqueductal gray (DLPAG) and in the rostral ventrolateral medulla (RVLM), an area that contains sympathoexcitatory C1 adrenergic (A) neurons. The release of 5-HT in either region inhibits stress-induced sympathetic activity in part via actions on 5-HT1A receptors. In addition, 5-HT release in the DLPAG inhibits fight-or-flight or "Go" behaviors. The origin of endogenous 5-HT in the DLPAG and RVLM seems to be a subpopulation of serotonergic neurons within the ventrolateral PAG, a region implicated in "freezing" or "No Go" behaviors. These serotonergic neurons are located in the lateral "wings" of the dorsal raphe nucleus (DRN) a region also referred to as the ventrolateral DRN. The existence of a functional subpopulation of serotonergic neurons capable of inhibiting sympathoexcitation and fight-or-flight behavioral responses may be clinically relevant for explaining in part the efficacy of serotonergic drugs in the treatment of hypertension and panic attacks in panic disorder patients.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1018
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

Serotonergic Neurons
Periaqueductal Gray
Panic
Neurons
Rats
Serotonin
Panic Disorder
Serotonin Agents
Adrenergic Neurons
Receptor, Serotonin, 5-HT1A
Aptitude
Inhibition (Psychology)
Neuron
Rat
Freezing
Adrenergic Agents
Modulators
Brain
Hypertension
Flight

Keywords

  • 5-HT
  • 5-HT
  • 5-hydroxytryptamine
  • Adrenaline
  • Anxiety
  • Epinephrine
  • Fear
  • RVLM

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic. / Johnson, Philip L.; Lightman, Stafford L.; Lowry, Christopher A.

In: Annals of the New York Academy of Sciences, Vol. 1018, 01.01.2004, p. 58-64.

Research output: Contribution to journalArticle

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