A GAP in our knowledge of vascular signaling in acute kidney injury

Research output: Contribution to journalComment/debate

Abstract

Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these factors signal through common G protein-coupled receptors. The report by Siedlecki et al. highlights the important roles of RGS4, a GTPase-accelerating protein (GAP), in the regulation of vascular tone in the setting of acute kidney injury.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalKidney international
Volume80
Issue number3
DOIs
StatePublished - Aug 1 2011

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ASJC Scopus subject areas

  • Nephrology

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