A GAP in our knowledge of vascular signaling in acute kidney injury

Research output: Contribution to journalArticle

Abstract

Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these factors signal through common G protein-coupled receptors. The report by Siedlecki et al. highlights the important roles of RGS4, a GTPase-accelerating protein (GAP), in the regulation of vascular tone in the setting of acute kidney injury.

Original languageEnglish
Pages (from-to)233-235
Number of pages3
JournalKidney International
Volume80
Issue number3
DOIs
StatePublished - Aug 1 2011

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GTP Phosphohydrolases
Reperfusion Injury
Acute Kidney Injury
Blood Vessels
G-Protein-Coupled Receptors
Vasoconstriction
Proteins
Wounds and Injuries

ASJC Scopus subject areas

  • Nephrology

Cite this

A GAP in our knowledge of vascular signaling in acute kidney injury. / Basile, David.

In: Kidney International, Vol. 80, No. 3, 01.08.2011, p. 233-235.

Research output: Contribution to journalArticle

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