A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas

Viji Shridhar, Sylvie Rivard, Ravi Shridhar, Chadwick Mullins, Laurie Bostick, Wael Sakr, David Grignon, O. J. Miller, David I. Smith

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We have identified a gene, called ARP for Arginine-rich protein, in human chromosomal band 3p21. It is approximately 600 Kb telomeric to the ACY1 locus and encodes a previously unidentified 234 amino acid long, highly basic protein. This gene is highly conserved at the DNA and RNA level. It is found in all species including hamster, rat, mouse, bovine and yeast. We have detected a point mutation (ATG50 to AGG) or deletion of ATG50 in 10 of 21 sporadic renal cell carcinomas. The mutable region is in an imperfect trinucleotide repeat in the coding region which is nonpolymorphic among 50 normal individuals examined. The point mutation (ATG50 to AGG) or deletion of codon 50 removes a methionine and increases the stretch of arginines encoded by the AGG repeats in the ARP gene.

Original languageEnglish (US)
Pages (from-to)1931-1939
Number of pages9
JournalOncogene
Volume12
Issue number9
StatePublished - Jun 3 1996

Keywords

  • 3p21.1 gene
  • Arginine-rich protein
  • Cryptic repeat
  • Mutations
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Shridhar, V., Rivard, S., Shridhar, R., Mullins, C., Bostick, L., Sakr, W., Grignon, D., Miller, O. J., & Smith, D. I. (1996). A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Oncogene, 12(9), 1931-1939.