A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

Richard Bell, S. Hauser, Zachary Rodd, Tiebing Liang, Y. Sari, Jeanette McClintick, S. Rahman, Eric Engleman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid animal model of alcoholism with a highlight on its use as an animal model of polysubstance abuse, including alcohol, nicotine, and psychostimulants. Pharmacologically and genetically, the focus will be on the neurotransmitter and neuropeptide systems that have received the most attention: cholinergic, dopaminergic, GABAergic, glutamatergic, serotonergic, noradrenergic, corticotrophin releasing hormone, opioid, and neuropeptide Y. Herein, we sought to place the P rat's behavioral and neurochemical phenotypes, and to some extent its genotype, in the context of the clinical literature. After reviewing the findings thus far, this chapter discusses future directions for expanding the use of this genetic animal model of alcoholism to identify molecular targets for treating drug addiction in general.

Original languageEnglish (US)
Pages (from-to)179-261
Number of pages83
JournalInternational Review of Neurobiology
Volume126
DOIs
StatePublished - 2016

Fingerprint

Genetic Models
Alcoholism
Animal Models
Behavioral Genetics
Neuropeptide Y
Corticotropin-Releasing Hormone
Neuropeptides
Nicotine
Cholinergic Agents
Opioid Analgesics
Substance-Related Disorders
Neurotransmitter Agents
Genotype
Alcohols
Pharmacology
Phenotype

Keywords

  • Alcohol
  • Animal models
  • CNS neurotransmitters
  • Dependence
  • Drug addiction
  • Family history
  • Genomics
  • Pharmacogenetics
  • Pharmacogenomics
  • Predisposition
  • Proteomics
  • Selective breeding

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. / Bell, Richard; Hauser, S.; Rodd, Zachary; Liang, Tiebing; Sari, Y.; McClintick, Jeanette; Rahman, S.; Engleman, Eric.

In: International Review of Neurobiology, Vol. 126, 2016, p. 179-261.

Research output: Contribution to journalArticle

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