A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

R. L. Bell, S. Hauser, Z. A. Rodd, T. Liang, Y. Sari, J. McClintick, S. Rahman, E. A. Engleman

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid animal model of alcoholism with a highlight on its use as an animal model of polysubstance abuse, including alcohol, nicotine, and psychostimulants. Pharmacologically and genetically, the focus will be on the neurotransmitter and neuropeptide systems that have received the most attention: cholinergic, dopaminergic, GABAergic, glutamatergic, serotonergic, noradrenergic, corticotrophin releasing hormone, opioid, and neuropeptide Y. Herein, we sought to place the P rat's behavioral and neurochemical phenotypes, and to some extent its genotype, in the context of the clinical literature. After reviewing the findings thus far, this chapter discusses future directions for expanding the use of this genetic animal model of alcoholism to identify molecular targets for treating drug addiction in general.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages179-261
Number of pages83
DOIs
StatePublished - 2016

Publication series

NameInternational Review of Neurobiology
Volume126
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514

Keywords

  • Alcohol
  • Animal models
  • CNS neurotransmitters
  • Dependence
  • Drug addiction
  • Family history
  • Genomics
  • Pharmacogenetics
  • Pharmacogenomics
  • Predisposition
  • Proteomics
  • Selective breeding

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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    Bell, R. L., Hauser, S., Rodd, Z. A., Liang, T., Sari, Y., McClintick, J., Rahman, S., & Engleman, E. A. (2016). A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. In International Review of Neurobiology (pp. 179-261). (International Review of Neurobiology; Vol. 126). Academic Press Inc.. https://doi.org/10.1016/bs.irn.2016.02.017