A genome screen of maximum number of drinks as an alcoholism phenotype

Nancy L. Saccone, Jennifer M. Kwon, Jonathan Corbett, Alison Goate, Nanette Rochberg, Howard Edenberg, Tatiana Foroud, Ting Kai Li, Henri Begleiter, Theodore Reich, John P. Rice

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

The Collaborative Study on the Genetics of Alcoholism (COGA) is a multicenter research program to detect and map susceptibility genes for alcohol dependence and related phenotypes. The measure M of 'maximum number of drinks consumed in a 24-hour period' is closely related to alcoholism diagnosis in this dataset and provides a quantitative measure to grade nonalcoholic individuals. Twin studies have shown log(M) to have a her/tability of approximately 50%. Genome screens for this trait were performed in two distinct genotyped samples (wave 1 and wave 2), and in the combined sample. MAPMAKER/SIBS was used to carry out Haseman-Elston based regression analyses. On chromosome 4, an unweighted all-pairs multipoint LOD of 2.2 was obtained between D4S2407 and D4S1628 in wave 1; in wave 2, the region flanked by D4S2404 and D4S2407 gave a LOD of 1.5. In the combined sample, the maximal LOD was 3.5 very close to D4S2407. This evidence for linkage is in the region of the alcohol dehydrogenase gene cluster on chromosome 4. These findings on chromosome 4 are consistent with a prior report from COGA in which strictly defined nonalcoholic subjects in wave 1 were analyzed. The present anaIysis on log(M) allows more individuals to be included and thus is potentially more powerful. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number5
DOIs
StatePublished - Oct 9 2000

Fingerprint

Chromosomes, Human, Pair 4
Alcoholism
Genome
Phenotype
Twin Studies
Alcohol Dehydrogenase
Multigene Family
Regression Analysis
Research
Genes

Keywords

  • Endophenotype
  • Linkage
  • Quantitative trait
  • Sib pair analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

A genome screen of maximum number of drinks as an alcoholism phenotype. / Saccone, Nancy L.; Kwon, Jennifer M.; Corbett, Jonathan; Goate, Alison; Rochberg, Nanette; Edenberg, Howard; Foroud, Tatiana; Li, Ting Kai; Begleiter, Henri; Reich, Theodore; Rice, John P.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 96, No. 5, 09.10.2000, p. 632-637.

Research output: Contribution to journalArticle

Saccone, Nancy L. ; Kwon, Jennifer M. ; Corbett, Jonathan ; Goate, Alison ; Rochberg, Nanette ; Edenberg, Howard ; Foroud, Tatiana ; Li, Ting Kai ; Begleiter, Henri ; Reich, Theodore ; Rice, John P. / A genome screen of maximum number of drinks as an alcoholism phenotype. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2000 ; Vol. 96, No. 5. pp. 632-637.
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