A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma

Xin Li, Marilyn C. Cornelis, Liming Liang, Fengju Song, Immaculata De Vivo, Edward Giovannucci, Jean Y. Tang, Jiali Han

Research output: Contribution to journalArticle

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Abstract

Animal models have suggested that oral or topical administration of caffeine could inhibit ultraviolet-induced carcinogenesis via the ataxia telangiectasia and rad3 (ATR)-related apoptosis. Previous epidemiological studies have demonstrated that increased caffeine consumption is associated with reduced risk of basal cell carcinoma (BCC). To identify common genetic markers that may modify this association, we tested gene-caffeine intake interaction on BCC risk in a genome-wide analysis. We included 3383 BCC cases and 8528 controls of European ancestry from the Nurses' Health Study and Health Professionals Follow-up Study. Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption (P = 1.78 × 10-8 for interaction) on BCC risk. There was no gender difference for this interaction (P = 0.64 for heterogeneity). NEIL3, a gene belonging to the base excision DNA repair pathway, encodes a DNA glycosylase that recognizes and removes lesions produced by oxidative stress. In addition, we identified several loci with P value for interaction < 5 × 10-7 in gender-specific analyses (P for heterogeneity between genders < 0.001) including those mapping to the genes LRRTM4, ATF3 and DCLRE1C in women and POTEA in men. Finally, we tested the associations between caffeine consumption-related SNPs reported by previous genome-wide association studies and risk of BCC, both individually and jointly, but found no significant association. In sum, we identified a DNA repair gene that could be involved in caffeine-mediated skin tumor inhibition. Further studies are warranted to confirm these findings.

Original languageEnglish (US)
Pages (from-to)1138-1143
Number of pages6
JournalCarcinogenesis
Volume37
Issue number12
DOIs
StatePublished - Jan 1 2016

Fingerprint

Basal Cell Carcinoma
Caffeine
Genome
DNA Repair
Genes
Single Nucleotide Polymorphism
DNA Glycosylases
Topical Administration
Ataxia Telangiectasia
Chromosome Mapping
Genome-Wide Association Study
Health
Genetic Markers
Oral Administration
Epidemiologic Studies
Carcinogenesis
Oxidative Stress
Animal Models
Nurses
Apoptosis

ASJC Scopus subject areas

  • Cancer Research

Cite this

A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. / Li, Xin; Cornelis, Marilyn C.; Liang, Liming; Song, Fengju; Vivo, Immaculata De; Giovannucci, Edward; Tang, Jean Y.; Han, Jiali.

In: Carcinogenesis, Vol. 37, No. 12, 01.01.2016, p. 1138-1143.

Research output: Contribution to journalArticle

Li, X, Cornelis, MC, Liang, L, Song, F, Vivo, ID, Giovannucci, E, Tang, JY & Han, J 2016, 'A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma', Carcinogenesis, vol. 37, no. 12, pp. 1138-1143. https://doi.org/10.1093/carcin/bgw107
Li X, Cornelis MC, Liang L, Song F, Vivo ID, Giovannucci E et al. A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. Carcinogenesis. 2016 Jan 1;37(12):1138-1143. https://doi.org/10.1093/carcin/bgw107
Li, Xin ; Cornelis, Marilyn C. ; Liang, Liming ; Song, Fengju ; Vivo, Immaculata De ; Giovannucci, Edward ; Tang, Jean Y. ; Han, Jiali. / A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. In: Carcinogenesis. 2016 ; Vol. 37, No. 12. pp. 1138-1143.
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